Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

• Published in: Arthritis research & therapy Vol. 20; no. 1; pp. 54 - 12
• Main Authors: Chi, Huihui, Liu, Dongzhou, Sun, Yue, Hu, Qiongyi, Liu, Honglei, Cheng, Xiaobing, Ye, Junna, Shi, Hui, Yin, Yufeng, Liu, Mengru, Wu, Xinyao, Zhou, Zhuochao, Teng, Jialin, Yang, Chengde, Su, Yutong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.03.2018; BioMed Central; BMC
• Subjects: Adult; Adult-onset Still’s disease; Biomarkers - blood; Cells, Cultured; Cytokines; Disease Progression; Female; Humans; IL-37; Interleukin-1 - blood; Interleukins; Leukocytes, Mononuclear - metabolism; Male; Middle Aged; Peripheral blood mononuclear cells; Physiological aspects; Still's Disease, Adult-Onset - blood; Still's Disease, Adult-Onset - diagnosis; Young Adult; Peripheral blood mononuclear cells; IL-37; Adult-onset Still’s disease; Cytokines

Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates in the regulation of pathogenesis of adult-onset Still's disease (AOSD) has not been investigated. In this study, we examined serum IL-37 levels and their clinical...