The role of shed placental DNA in the systemic inflammatory syndrome of preeclampsia

• Published in: American journal of obstetrics and gynecology Vol. 213; no. 3; pp. 268 - 277
• Main Authors: Hartley, James D.R., Ferguson, Brian J., Moffett, Ashley
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015
• Subjects: Cell-Derived Microparticles - immunology; Cell-Derived Microparticles - metabolism; Cytokines - immunology; Cytokines - metabolism; DNA - immunology; DNA - metabolism; Female; Humans; Hypoxia - immunology; Hypoxia - metabolism; inflammation; Leptin - immunology; Leptin - metabolism; Obstetrics and Gynecology; Placenta - blood supply; Placenta - immunology; Placenta - metabolism; placental DNA; Pre-Eclampsia - immunology; Pre-Eclampsia - metabolism; preeclampsia; Pregnancy; Systemic Inflammatory Response Syndrome - immunology; Systemic Inflammatory Response Syndrome - metabolism; Trophoblasts - cytology; Vascular Endothelial Growth Factor Receptor-1 - metabolism; placental DNA; inflammation; preeclampsia

Preeclampsia is a syndrome occurring only in pregnancy characterized by systemic maternal inflammation and associated with the presence of the placenta. How these 2 aspects of the disease are linked has been the subject of numerous theories and ideas. Recently, there has been increasing interest in...