Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France

• Published in: European heart journal Vol. 40; no. 43; pp. 3516 - 3525
• Main Authors: Giral, Philippe, Neumann, Anke, Weill, Alain, Coste, Joël
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 14.11.2019; Oxford University Press (OUP)
• Subjects: Age Factors; Aged; Cardiology and cardiovascular system; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - prevention & control; Clinical Research; Databases, Factual; Editor's Choice; Female; Follow-Up Studies; France - epidemiology; Human health and pathology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Life Sciences; Male; Pharmaceutical sciences; Pharmacology; Primary Prevention - methods; Retrospective Studies; Risk Assessment; Risk Factors; Santé publique et épidémiologie; Withholding Treatment; France; Cardiovascular disease; Treatment discontinuation; Primary prevention; Elderly; Statins

Abstract Aims The role of statin therapy in primary prevention of cardiovascular disease in persons older than 75 years remains a subject of debate with little evidence to support or exclude the benefit of this treatment. We assessed the effect of statin discontinuation on cardiovascular outcomes in...