Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin

• Published in: Journal of cancer research and clinical oncology Vol. 138; no. 1; pp. 23 - 33
• Main Authors: Orozco-Morales, Mario, Sánchez-García, Francisco-Javier, Guevara-Salazar, Patricia, Arrieta, Oscar, Hernández-Pedro, Norma Y., Sánchez-García, Aurora, Perez-Madrigal, Rodolfo, Rangel-López, Edgar, Pineda, Benjamín, Sotelo, Julio
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2012; Springer; Springer Nature B.V
• Subjects: Adjuvants; Animals; Antineoplastic agents; Apoptosis; Apoptosis - drug effects; Apoptosis - immunology; Biological and medical sciences; Blood; Brain cancer; Cancer Research; CD25 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; Chemokine CCL3 - biosynthesis; Chemokine CCL3 - genetics; Chemokine CCL3 - immunology; Cytokines; Female; Foxp3 protein; Gene expression; Glioblastoma; Glioma - drug therapy; Glioma - immunology; Glioma - pathology; Glioma cells; Granzymes - biosynthesis; Granzymes - genetics; Granzymes - immunology; Hematology; Immune system; Immunologic Factors - immunology; Immunologic Factors - pharmacology; Immunomodulation; Immunosuppressive agents; Immunotherapy; Inflammation; Interleukin 6; Interleukin-2 Receptor alpha Subunit - immunology; Interleukin-6 - biosynthesis; Interleukin-6 - genetics; Interleukin-6 - immunology; Internal Medicine; Lymphocytes T; macrophage inflammatory protein 1; Macrophages - drug effects; Macrophages - immunology; Medical sciences; Medicine; Medicine & Public Health; Monocyte chemoattractant protein 1; Neurology; Oncology; Original Paper; Perforin; Perforin - biosynthesis; Perforin - genetics; Perforin - immunology; pertussis toxin; Pertussis Toxin - immunology; Pertussis Toxin - pharmacology; Pharmacology. Drug treatments; Prognosis; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Rodents; Spleen; Surgery; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; Tumors of the nervous system. Phacomatoses; C6 glioma; Regulatory T cells; Glioblastoma multiforme; Pertussis toxin; Immunotherapeutic; Nervous system diseases; Rat; Rodentia; Adjuvant treatment; Malignant tumor; Malignant glioma; Vertebrata; Mammalia; Animal; Immunotherapy; Central nervous system disease; T-Lymphocyte; Regulatory cell; Cancer

Purpose In spite of the recent advances in surgery and antitumor drugs, the brain tumors, like glioblastoma, have shown a poor prognosis. The aim of this study was to determine the effect of pertussis toxin (PTx) as immunomodulatory molecule on glial tumors induced by C6 glioma cells. Methods Given...