Association weight matrix for the genetic dissection of puberty in beef cattle

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 31; pp. 13642 - 13647
• Main Authors: Fortes, Marina R. S., Reverter, Antonio, Zhang, Yuandan, Collis, Eliza, Nagaraj, Shivashankar H., Jonsson, Nick N., Prayaga, Kishore C., Barris, Wes, Hawken, Rachel J., Seidel, George
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 03.08.2010; National Acad Sciences
• Subjects: Aging; Animal genetics; Animals; Beef; Beef cattle; Binding sites; Biological Sciences; Cattle - genetics; Cells; Gene interaction; Gene Regulatory Networks; Genes; Genetic correlation; Genome-Wide Association Study; Genomics; Medical genetics; Phenotypes; Phenotypic traits; Polymorphism; Polymorphism, Single Nucleotide; Puberty; Receptors; Systems Biology

We describe a systems biology approach for the genetic dissection of complex traits based on applying gene network theory to the results from genome-wide associations. The associations of single-nucleotide polymorphisms (SNP) that were individually associated with a primary phenotype of interest, ag...