Identification of collapsin response mediator protein-2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomes

• Published in: Proteomics (Weinheim) Vol. 8; no. 2; pp. 316 - 332
• Main Authors: Wu, Chih-Ching, Chen, Hua-Chien, Chen, Su-Jen, Liu, Hao-Ping, Hsieh, Yi-Yueh, Yu, Chia-Jung, Tang, Reiping, Hsieh, Ling-Ling, Yu, Jau-Song, Chang, Yu-Sun
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 01.01.2008; WILEY-VCH Verlag; WILEY‐VCH Verlag; Wiley-VCH
• Subjects: Analytical, structural and metabolic biochemistry; Biological and medical sciences; Biomarkers, Tumor - analysis; Cell Line, Tumor; Colorectal carcinoma; Colorectal Neoplasms - secretion; CRMP-2; Electrophoresis, Polyacrylamide Gel; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Intercellular Signaling Peptides and Proteins - analysis; Male; Medical sciences; Middle Aged; Miscellaneous; Nerve Tissue Proteins - analysis; Proteins; Proteome - analysis; Secretome; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumor marker; Tumors; Rectal disease; Colorectal carcinoma; Colorectal cancer; Identification; Secretome; Malignant tumor; CRMP-2; Protein; Colonic disease; Tumor marker; Proteomics; Digestive diseases; Intestinal disease; Cancer

The cancer cell secretome may contain many potentially useful biomarkers. We therefore sought to identify proteins in the conditioned media of colorectal carcinoma (CRC) cell lines but not in those from other cancer cell lines. The secretomes of 21 cancer cell lines derived from 12 cancer types were...