In Medication-Overuse Headache, fMRI Shows Long-Lasting Dysfunction in Midbrain Areas

• Published in: Headache Vol. 52; no. 10; pp. 1520 - 1534
• Main Authors: Ferraro, Stefania, Grazzi, Licia, Muffatti, Riccardo, Nava, Simone, Ghielmetti, Francesco, Bertolino, Nicola, Mandelli, Maria Luisa, Visintin, Eleonora, Bruzzone, Maria Grazia, Nigri, Anna, Epifani, Francesca, Bussone, Gennaro, Chiapparini, Luisa
• Format: Journal Article
• Language: English
• Published: Malden, MA Blackwell Publishing Ltd 01.11.2012; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Addiction; Addictions; Addictive behaviors; Adult; Biological and medical sciences; Brain; Circuits; Cortex (prefrontal); Data processing; Decision making; decision-making under risk; Dopamine; Female; Functional magnetic resonance imaging; Headache; Headache Disorders, Secondary - diagnosis; Headache Disorders, Secondary - physiopathology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Headaches; Humans; Magnetic Resonance Imaging - trends; Medical sciences; medication-overuse headache; Mesencephalon; Mesencephalon - physiopathology; mesocorticolimbic dopamine circuit; Middle Aged; Migraine; Nervous system (semeiology, syndromes); Neuroimaging; Neurology; NMR; Nuclear magnetic resonance; Substantia nigra; Time Factors; Vascular diseases and vascular malformations of the nervous system; Ventral tegmentum; Withdrawal; Headache; Nervous system diseases; Dopamine; Decision making; medication-overuse headache; Midbrain; Catecholamine; Nuclear magnetic resonance imaging; Cerebral disorder; mesocorticolimbic dopamine circuit; Chemotherapy; Treatment; Pain; Addiction; Central nervous system disease; Risk factor; Neurotransmitter; Drug of abuse; decision-making under risk; Neurological disorder; Long lasting; Cerebrovascular disease; functional magnetic resonance imaging; Functional imaging; addiction

Objective. The primary aim of our study was to evaluate if a group of medication‐overuse headache (MOH) patients present dysfunctions in the mesocorticolimbic dopamine circuit. The secondary aim was to disentangle the role of the medication overuse and of the acute/chronic headache in determining th...