Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus‐71 infection in Chinese children

• Published in: Immunity, Inflammation and Disease Vol. 10; no. 5; pp. e614 - n/a
• Main Authors: Song, Jie, Liu, Yedan, Guo, Ya, Liu, Peipei, Li, Fei, Yang, Chengqing, Pan, Xiaoyu, Yi, Liping, Fan, Fan, Zhao, Han, Chen, Zongbo
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2022; John Wiley and Sons Inc; Wiley
• Subjects: Breast cancer; Child; Children & youth; China - epidemiology; Encephalitis; Enterovirus A, Human - genetics; Enterovirus Infections - genetics; Epidemics; EV71 infection; Families & family life; Genetic Predisposition to Disease; Genotype & phenotype; Hospitals; Humans; IL‐6/NF‐κB; Immune system; Infections; Interleukin-1 Receptor-Associated Kinases - genetics; Interleukin-6 - genetics; IRAK4; Kinases; NF-kappa B - genetics; Original; Pathogens; Polymorphism; Polymorphism, Single Nucleotide; RNA, Messenger; Signal transduction; single‐nucleotide polymorphism; China; IRAK4; single-nucleotide polymorphism; EV71 infection; IL-6/NF-κB

Introduction This study aimed to explore the association between the IRAK4 polymorphism rs4251545 and the severity of enterovirus 71 (EV71) infection in Chinese children. Methods We analyzed the IRAK4 polymorphism rs4251545 in 617 EV71‐infected patients and 410 controls using the improved multiplex...