Proteomic Analysis Demonstrates Adolescent Vulnerability to Lasting Hippocampal Changes Following Chronic Alcohol Consumption

• Published in: Alcoholism, clinical and experimental research Vol. 33; no. 1; pp. 86 - 94
• Main Authors: Hargreaves, Garth A., Quinn, Heidi, Kashem, Mohammed A., Matsumoto, Izuru, McGregor, Iain S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2009; Wiley
• Subjects: Aging - drug effects; Aging - metabolism; Aging - pathology; Alcohol; Alcohol Drinking - metabolism; Alcohol Drinking - pathology; Alcohol Drinking - physiopathology; Alcoholism and acute alcohol poisoning; Animals; Biological and medical sciences; Brain Chemistry - drug effects; Brain Chemistry - physiology; Disease Susceptibility - chemically induced; Disease Susceptibility - metabolism; Disease Susceptibility - physiopathology; Glycolysis; Hippocampus; Hippocampus - chemistry; Hippocampus - drug effects; Hippocampus - physiopathology; Male; Medical sciences; Proteome; Proteomics - methods; Rats; Rats, Wistar; Toxicology; Wistar Rat; Human; Consumption; Ethanol; Rat; Rodentia; Central nervous system; Proteome; Alcohol; Vulnerability; Encephalon; Alcoholic beverage; Vertebrata; Chronic; Mammalia; Animal; Adolescent; Proteomics; Glycolysis; Hippocampus; Proteome. Wistar Rat

Background:  Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein express...