Proteomic Analysis Demonstrates Adolescent Vulnerability to Lasting Hippocampal Changes Following Chronic Alcohol Consumption
Background: Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein express...
Saved in:
| Published in | Alcoholism, clinical and experimental research Vol. 33; no. 1; pp. 86 - 94 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2009
Wiley |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Background: Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein expression to a greater extent than during adulthood.
Methods: Adolescent [postnatal day (PND) 27] and adult (PND 55) male Wistar rats were given 8 hours daily access to beer (4.44% ethanol v/v) in addition to ad libitum food and water for 4 weeks. From a large subject pool, subgroups of adolescent and adult rats were selected that displayed equivalent alcohol intake (average of 6.1 g/kg/day ethanol). The 4 weeks of alcohol access were followed by a 2‐week alcohol‐free washout period after which the hippocampus was analyzed using 2‐DE proteomics.
Results: Beer consumption by the adult group resulted in modest hippocampal changes relative to alcohol naïve adult controls. The only changes observed were an up‐regulation of citrate synthase (a precursor to the Krebs cycle) and fatty acid binding protein (which facilitates fatty acid metabolism). In contrast, adolescent rats consuming alcohol showed more widespread hippocampal changes relative to adolescent controls. These included an increase in cytoskeletal protein T‐complex protein 1 subunit epsilon (TCP‐1) and a decrease in the expression of 10 other proteins, including glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), triose phosphate isomerise, alpha‐enolase, and phosphoglycerate kinase 1 (all involved in glycolysis); glutamate dehydrogenase 1 (an important regulator of glutamate); methylmalonate‐semialdehyde dehydrogenase (involved in aldehyde detoxification); ubiquitin carboxyl‐terminal hydrolase isozyme L1 (a regulator of protein degradation); and synapsin 2 (involved in synaptogenesis and neurotransmitter release).
Conclusions: These results suggest the adolescent hippocampus is more vulnerable to lasting proteomic changes following repeated alcohol exposure. The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure. |
|---|---|
| AbstractList | Background: Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein expression to a greater extent than during adulthood.
Methods: Adolescent [postnatal day (PND) 27] and adult (PND 55) male Wistar rats were given 8 hours daily access to beer (4.44% ethanol v/v) in addition to ad libitum food and water for 4 weeks. From a large subject pool, subgroups of adolescent and adult rats were selected that displayed equivalent alcohol intake (average of 6.1 g/kg/day ethanol). The 4 weeks of alcohol access were followed by a 2‐week alcohol‐free washout period after which the hippocampus was analyzed using 2‐DE proteomics.
Results: Beer consumption by the adult group resulted in modest hippocampal changes relative to alcohol naïve adult controls. The only changes observed were an up‐regulation of citrate synthase (a precursor to the Krebs cycle) and fatty acid binding protein (which facilitates fatty acid metabolism). In contrast, adolescent rats consuming alcohol showed more widespread hippocampal changes relative to adolescent controls. These included an increase in cytoskeletal protein T‐complex protein 1 subunit epsilon (TCP‐1) and a decrease in the expression of 10 other proteins, including glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), triose phosphate isomerise, alpha‐enolase, and phosphoglycerate kinase 1 (all involved in glycolysis); glutamate dehydrogenase 1 (an important regulator of glutamate); methylmalonate‐semialdehyde dehydrogenase (involved in aldehyde detoxification); ubiquitin carboxyl‐terminal hydrolase isozyme L1 (a regulator of protein degradation); and synapsin 2 (involved in synaptogenesis and neurotransmitter release).
Conclusions: These results suggest the adolescent hippocampus is more vulnerable to lasting proteomic changes following repeated alcohol exposure. The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure. Background:Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein expression to a greater extent than during adulthood.Methods:Adolescent [postnatal day (PND) 27] and adult (PND 55) male Wistar rats were given 8hours daily access to beer (4.44% ethanol v/v) in addition to ad libitum food and water for 4weeks. From a large subject pool, subgroups of adolescent and adult rats were selected that displayed equivalent alcohol intake (average of 6.1g/kg/day ethanol). The 4weeks of alcohol access were followed by a 2-week alcohol-free washout period after which the hippocampus was analyzed using 2-DE proteomics.Results:Beer consumption by the adult group resulted in modest hippocampal changes relative to alcohol naive adult controls. The only changes observed were an up-regulation of citrate synthase (a precursor to the Krebs cycle) and fatty acid binding protein (which facilitates fatty acid metabolism). In contrast, adolescent rats consuming alcohol showed more widespread hippocampal changes relative to adolescent controls. These included an increase in cytoskeletal protein T-complex protein 1 subunit epsilon (TCP-1) and a decrease in the expression of 10 other proteins, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), triose phosphate isomerise, alpha-enolase, and phosphoglycerate kinase 1 (all involved in glycolysis); glutamate dehydrogenase 1 (an important regulator of glutamate); methylmalonate-semialdehyde dehydrogenase (involved in aldehyde detoxification); ubiquitin carboxyl-terminal hydrolase isozyme L1 (a regulator of protein degradation); and synapsin 2 (involved in synaptogenesis and neurotransmitter release).Conclusions:These results suggest the adolescent hippocampus is more vulnerable to lasting proteomic changes following repeated alcohol exposure. The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure. Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein expression to a greater extent than during adulthood. Adolescent [postnatal day (PND) 27] and adult (PND 55) male Wistar rats were given 8 hours daily access to beer (4.44% ethanol v/v) in addition to ad libitum food and water for 4 weeks. From a large subject pool, subgroups of adolescent and adult rats were selected that displayed equivalent alcohol intake (average of 6.1 g/kg/day ethanol). The 4 weeks of alcohol access were followed by a 2-week alcohol-free washout period after which the hippocampus was analyzed using 2-DE proteomics. Beer consumption by the adult group resulted in modest hippocampal changes relative to alcohol naïve adult controls. The only changes observed were an up-regulation of citrate synthase (a precursor to the Krebs cycle) and fatty acid binding protein (which facilitates fatty acid metabolism). In contrast, adolescent rats consuming alcohol showed more widespread hippocampal changes relative to adolescent controls. These included an increase in cytoskeletal protein T-complex protein 1 subunit epsilon (TCP-1) and a decrease in the expression of 10 other proteins, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), triose phosphate isomerise, alpha-enolase, and phosphoglycerate kinase 1 (all involved in glycolysis); glutamate dehydrogenase 1 (an important regulator of glutamate); methylmalonate-semialdehyde dehydrogenase (involved in aldehyde detoxification); ubiquitin carboxyl-terminal hydrolase isozyme L1 (a regulator of protein degradation); and synapsin 2 (involved in synaptogenesis and neurotransmitter release). These results suggest the adolescent hippocampus is more vulnerable to lasting proteomic changes following repeated alcohol exposure. The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure. Background: Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein expression to a greater extent than during adulthood. Methods: Adolescent [postnatal day (PND) 27] and adult (PND 55) male Wistar rats were given 8 hours daily access to beer (4.44% ethanol v/v) in addition to ad libitum food and water for 4 weeks. From a large subject pool, subgroups of adolescent and adult rats were selected that displayed equivalent alcohol intake (average of 6.1 g/kg/day ethanol). The 4 weeks of alcohol access were followed by a 2‐week alcohol‐free washout period after which the hippocampus was analyzed using 2‐DE proteomics. Results: Beer consumption by the adult group resulted in modest hippocampal changes relative to alcohol naïve adult controls. The only changes observed were an up‐regulation of citrate synthase (a precursor to the Krebs cycle) and fatty acid binding protein (which facilitates fatty acid metabolism). In contrast, adolescent rats consuming alcohol showed more widespread hippocampal changes relative to adolescent controls. These included an increase in cytoskeletal protein T‐complex protein 1 subunit epsilon (TCP‐1) and a decrease in the expression of 10 other proteins, including glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), triose phosphate isomerise, alpha‐enolase, and phosphoglycerate kinase 1 (all involved in glycolysis); glutamate dehydrogenase 1 (an important regulator of glutamate); methylmalonate‐semialdehyde dehydrogenase (involved in aldehyde detoxification); ubiquitin carboxyl‐terminal hydrolase isozyme L1 (a regulator of protein degradation); and synapsin 2 (involved in synaptogenesis and neurotransmitter release). Conclusions: These results suggest the adolescent hippocampus is more vulnerable to lasting proteomic changes following repeated alcohol exposure. The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure. Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein expression to a greater extent than during adulthood.BACKGROUNDExcessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present study was to assess whether chronic intermittent alcohol intake during the adolescent period alters hippocampal protein expression to a greater extent than during adulthood.Adolescent [postnatal day (PND) 27] and adult (PND 55) male Wistar rats were given 8 hours daily access to beer (4.44% ethanol v/v) in addition to ad libitum food and water for 4 weeks. From a large subject pool, subgroups of adolescent and adult rats were selected that displayed equivalent alcohol intake (average of 6.1 g/kg/day ethanol). The 4 weeks of alcohol access were followed by a 2-week alcohol-free washout period after which the hippocampus was analyzed using 2-DE proteomics.METHODSAdolescent [postnatal day (PND) 27] and adult (PND 55) male Wistar rats were given 8 hours daily access to beer (4.44% ethanol v/v) in addition to ad libitum food and water for 4 weeks. From a large subject pool, subgroups of adolescent and adult rats were selected that displayed equivalent alcohol intake (average of 6.1 g/kg/day ethanol). The 4 weeks of alcohol access were followed by a 2-week alcohol-free washout period after which the hippocampus was analyzed using 2-DE proteomics.Beer consumption by the adult group resulted in modest hippocampal changes relative to alcohol naïve adult controls. The only changes observed were an up-regulation of citrate synthase (a precursor to the Krebs cycle) and fatty acid binding protein (which facilitates fatty acid metabolism). In contrast, adolescent rats consuming alcohol showed more widespread hippocampal changes relative to adolescent controls. These included an increase in cytoskeletal protein T-complex protein 1 subunit epsilon (TCP-1) and a decrease in the expression of 10 other proteins, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), triose phosphate isomerise, alpha-enolase, and phosphoglycerate kinase 1 (all involved in glycolysis); glutamate dehydrogenase 1 (an important regulator of glutamate); methylmalonate-semialdehyde dehydrogenase (involved in aldehyde detoxification); ubiquitin carboxyl-terminal hydrolase isozyme L1 (a regulator of protein degradation); and synapsin 2 (involved in synaptogenesis and neurotransmitter release).RESULTSBeer consumption by the adult group resulted in modest hippocampal changes relative to alcohol naïve adult controls. The only changes observed were an up-regulation of citrate synthase (a precursor to the Krebs cycle) and fatty acid binding protein (which facilitates fatty acid metabolism). In contrast, adolescent rats consuming alcohol showed more widespread hippocampal changes relative to adolescent controls. These included an increase in cytoskeletal protein T-complex protein 1 subunit epsilon (TCP-1) and a decrease in the expression of 10 other proteins, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), triose phosphate isomerise, alpha-enolase, and phosphoglycerate kinase 1 (all involved in glycolysis); glutamate dehydrogenase 1 (an important regulator of glutamate); methylmalonate-semialdehyde dehydrogenase (involved in aldehyde detoxification); ubiquitin carboxyl-terminal hydrolase isozyme L1 (a regulator of protein degradation); and synapsin 2 (involved in synaptogenesis and neurotransmitter release).These results suggest the adolescent hippocampus is more vulnerable to lasting proteomic changes following repeated alcohol exposure. The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure.CONCLUSIONSThese results suggest the adolescent hippocampus is more vulnerable to lasting proteomic changes following repeated alcohol exposure. The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure. |
| Author | Hargreaves, Garth A. Matsumoto, Izuru McGregor, Iain S. Kashem, Mohammed A. Quinn, Heidi |
| Author_xml | – sequence: 1 givenname: Garth A. surname: Hargreaves fullname: Hargreaves, Garth A. organization: From the School of Psychology (GAH, HQ, MAK, ISM), The University of Sydney, and Department of Pathology (IM), The University of Sydney, New South Wales, Australia – sequence: 2 givenname: Heidi surname: Quinn fullname: Quinn, Heidi organization: From the School of Psychology (GAH, HQ, MAK, ISM), The University of Sydney, and Department of Pathology (IM), The University of Sydney, New South Wales, Australia – sequence: 3 givenname: Mohammed A. surname: Kashem fullname: Kashem, Mohammed A. organization: From the School of Psychology (GAH, HQ, MAK, ISM), The University of Sydney, and Department of Pathology (IM), The University of Sydney, New South Wales, Australia – sequence: 4 givenname: Izuru surname: Matsumoto fullname: Matsumoto, Izuru organization: From the School of Psychology (GAH, HQ, MAK, ISM), The University of Sydney, and Department of Pathology (IM), The University of Sydney, New South Wales, Australia – sequence: 5 givenname: Iain S. surname: McGregor fullname: McGregor, Iain S. organization: From the School of Psychology (GAH, HQ, MAK, ISM), The University of Sydney, and Department of Pathology (IM), The University of Sydney, New South Wales, Australia |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21316106$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18945221$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkV9v0zAUxS00xP7AV0B5gbeUaydx3AeQqrB1SBVMaIC0F8txndXFsTPb1doHvjsOLX3gZViybPn-zpHvPefoxDqrEMowTHBa79YTXBWQA6nrCQFgk7RxOdk-Q2fHwgk6A1xWOU21U3QewhoASkbpC3SK2bSsCMFn6NeNd1G5XstsZoXZBR2yj6p3NkQvogrZbOmMClLZmH3fGKu8aLXRcZdFly1EiNreZ9d6GJwU_SBM1qyEvU-6K2eMexyrzco7O_ob6VYuEcl80w9RO_sSPe-ECerV4bxA364ub5vrfPFl_qmZLXJZFaTMaYeVqBlMy7btVNdiRqFdCpgSUTGoymkNsmYqdUVkxRQRVKQX0klSqGXd1cUFerv3Hbx72KgQea9TT8YIq9wmcEoZFAw_DRIgjBIMCXx9ADdtr5Z88LoXfsf_TjYBbw6ACFKYzgsrdThyicAUA03chz0nvQvBq45LHcU4nBSANhwDHyPnaz4my8dk-Rg5_xM53yYD9o_B8S9PS9_vpY_aqN1_6_isufyabkmf7_U6RLU96oX_yWld1BX_8XnOb6C5u5vfAifFb1WL04o |
| CODEN | ACRSDM |
| CitedBy_id | crossref_primary_10_4238_2012_February_17_2 crossref_primary_10_1016_j_neuropharm_2015_12_011 crossref_primary_10_3389_fnins_2016_00222 crossref_primary_10_1007_s11064_012_0768_3 crossref_primary_10_1016_j_alcohol_2010_12_007 crossref_primary_10_1002_hipo_20665 crossref_primary_10_1021_acs_chemrestox_7b00260 crossref_primary_10_1016_j_alcohol_2009_02_005 crossref_primary_10_1038_s41398_022_02100_y crossref_primary_10_3389_fpsyt_2017_00283 crossref_primary_10_1016_j_pneurobio_2009_10_020 crossref_primary_10_2174_1874467213666200424155244 crossref_primary_10_1038_npp_2013_182 crossref_primary_10_1016_j_nlm_2022_107661 crossref_primary_10_1016_j_pbb_2012_04_010 crossref_primary_10_1016_j_alcohol_2009_11_001 crossref_primary_10_1016_j_neuint_2012_08_013 crossref_primary_10_1097_YCO_0b013e32833864fe crossref_primary_10_1111_j_1369_1600_2009_00189_x crossref_primary_10_1093_alcalc_agaa007 crossref_primary_10_1016_j_neulet_2013_05_011 crossref_primary_10_1111_j_1742_7843_2011_00819_x crossref_primary_10_1016_j_bbr_2011_07_058 crossref_primary_10_1016_j_pbb_2011_03_002 crossref_primary_10_1016_j_jep_2012_06_039 crossref_primary_10_1016_j_alcohol_2009_10_015 crossref_primary_10_1007_s11064_018_2600_1 crossref_primary_10_1016_j_neuint_2019_02_009 crossref_primary_10_1016_j_neuint_2010_03_002 crossref_primary_10_1016_j_neuroscience_2014_11_013 crossref_primary_10_1371_journal_pone_0110073 crossref_primary_10_1016_j_neuroscience_2011_04_027 crossref_primary_10_3389_fnbeh_2022_954319 crossref_primary_10_1038_npp_2014_178 crossref_primary_10_1007_s12035_011_8202_4 crossref_primary_10_1007_s11064_014_1274_6 crossref_primary_10_18097_BMCRM00076 crossref_primary_10_1017_S0954579413000771 crossref_primary_10_1016_j_bbr_2014_04_023 crossref_primary_10_1088_1478_3975_aa5d71 |
| Cites_doi | 10.1111/j.1530-0277.2007.00444.x 10.1038/sj.tpj.6500420 10.1007/s00213-002-1281-1 10.1097/01.ALC.0000075826.35688.0D 10.1007/s00018-002-8451-5 10.1016/j.neuint.2007.05.007 10.1586/14789450.5.2.321 10.1016/S0092-8674(02)01012-7 10.1080/0959523031000154418 10.1111/j.1530-0277.1998.tb03668.x 10.1016/j.biopsych.2005.04.025 10.1016/j.neuroscience.2005.08.090 10.1006/nbdi.1998.0177 10.1176/appi.ajp.157.5.737 10.1111/j.1530-0277.1996.tb01665.x 10.1016/j.neuint.2007.04.001 10.1126/science.8430330 10.1523/JNEUROSCI.3063-04.2004 10.1016/j.pbb.2006.12.001 10.1038/sj.npp.1301475 10.1111/j.1530-0277.1998.tb03932.x 10.1093/alcalc/agm067 10.1016/S0165-3806(00)00015-8 10.1152/ajpgi.00193.2005 10.1016/j.pnpbp.2007.08.040 10.1111/j.1530-0277.2007.00437.x 10.1073/pnas.94.18.9669 10.1111/j.1530-0277.2006.00010.x 10.1017/S0033291798006849 10.1016/j.pbb.2005.12.004 10.1146/annurev.bb.15.060186.000525 10.1002/cne.902970107 10.1016/j.alcohol.2006.10.001 10.1016/j.tcb.2004.09.015 10.1016/0003-2697(76)90527-3 10.1093/hmg/ddg211 10.1002/pmic.200500725 10.1016/S0169-328X(98)00347-7 10.1038/bjp.2008.88 10.1007/s00204-003-0465-8 10.1097/01.alc.0000175012.77756.d9 10.1016/S0376-8716(03)00135-2 10.1016/j.neuint.2006.10.009 10.1111/j.1530-0277.2007.00418.x 10.1038/sj.tpj.6500309 10.1046/j.1471-4159.2002.00860.x 10.1002/prca.200600417 10.1002/jnr.10054 10.1016/0091-3057(87)90502-8 10.1016/j.jchromb.2007.05.023 10.1111/j.1530-0277.1993.tb00721.x 10.1038/sj.npp.1300947 10.1016/j.addbeh.2004.06.011 10.1111/j.1530-0277.2007.00602.x 10.1016/S0197-0186(00)00061-9 10.1073/pnas.0511321103 10.2741/Cunning 10.1111/j.1530-0277.1997.tb03798.x 10.1016/j.cell.2006.06.046 10.1073/pnas.1530509100 10.1006/abbi.1997.0514 10.1111/j.1530-0277.2000.tb02091.x 10.1038/sj.mp.4001741 10.1002/ana.410310202 10.1093/hmg/10.18.1963 10.1111/j.1530-0277.2006.00223.x 10.1242/jcs.01171 10.1111/j.1460-9568.2005.04120.x 10.1002/pmic.200600595 10.1016/S0149-7634(00)00014-2 10.1006/abbi.2001.2433 10.1016/S0163-7827(96)00006-9 10.1111/j.1530-0277.1995.tb01509.x 10.1016/j.ntt.2006.10.010 10.1016/j.yexcr.2005.11.017 10.1002/pmic.200400958 10.1074/jbc.275.8.5958 10.1111/j.1530-0277.2007.00485.x 10.1038/ncb1268 10.1111/j.1530-0277.1995.tb01011.x |
| ContentType | Journal Article |
| Copyright | Copyright © 2008 by the Research Society on Alcoholism 2009 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 2008 by the Research Society on Alcoholism – notice: 2009 INIST-CNRS |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7TK 7X8 |
| DOI | 10.1111/j.1530-0277.2008.00814.x |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Neurosciences Abstracts MEDLINE - Academic |
| DatabaseTitleList | Neurosciences Abstracts MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Social Welfare & Social Work |
| EISSN | 1530-0277 |
| EndPage | 94 |
| ExternalDocumentID | 18945221 21316106 10_1111_j_1530_0277_2008_00814_x ACER814 ark_67375_WNG_P0CZZGT0_2 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | --- -ET -~X .3N .55 .GA .Y3 05W 08G 0R~ 10A 1OB 1OC 23M 31~ 33P 36B 3SF 4.4 4Q1 4Q2 4Q3 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 A8Z AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAWTL AAXRX AAZKR ABCQN ABCUV ABEML ABIVO ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFO ACGFS ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBIZ ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFTRI AFUWQ AFZJQ AHBTC AHEFC AHMBA AHRYX AI. AIACR AIAGR AITYG AIURR AIWBW AIZYK AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AWKKM AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DUUFO EBD EBS EJD EMB EMOBN EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IX1 J0M K48 KBYEO KMI L89 LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NTWIH O66 O9- OAG OAH OIG OL1 OMB OPX OVD OWU OWV OWW OWX OWY OWZ P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SJN SUPJJ SV3 TEORI TWZ UAP UB1 VH1 VVN W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOQ WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 XSW XYM YFH ZFV ZGI ZZTAW ~IA ~WT AAHQN AAIPD AAMNL AANHP AAYCA ACRPL ACYXJ ADNMO AFWVQ BYPQX AAYXX AGQPQ AGYGG CITATION IQODW CGR CUY CVF ECM EIF NPM 7TK 7X8 |
| ID | FETCH-LOGICAL-c5324-6f1ea78094bbfefb1860bda092a58054970c78e1892c58e2a6a70c2fc23ed7f73 |
| IEDL.DBID | DR2 |
| ISSN | 0145-6008 1530-0277 |
| IngestDate | Fri Jul 11 08:09:53 EDT 2025 Fri Jul 11 04:44:31 EDT 2025 Wed Feb 19 01:47:09 EST 2025 Mon Jul 21 09:14:46 EDT 2025 Thu Apr 24 22:56:08 EDT 2025 Tue Jul 01 04:01:39 EDT 2025 Wed Jan 22 17:04:56 EST 2025 Wed Oct 30 09:54:07 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Human Consumption Ethanol Rat Rodentia Central nervous system Proteome Alcohol Vulnerability Encephalon Alcoholic beverage Vertebrata Chronic Mammalia Animal Adolescent Proteomics Glycolysis Hippocampus Proteome. Wistar Rat |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5324-6f1ea78094bbfefb1860bda092a58054970c78e1892c58e2a6a70c2fc23ed7f73 |
| Notes | ark:/67375/WNG-P0CZZGT0-2 ArticleID:ACER814 istex:B03CB237F3E0385F9BBDB9A05C687560BF3F736D ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 18945221 |
| PQID | 20286210 |
| PQPubID | 23462 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_66803817 proquest_miscellaneous_20286210 pubmed_primary_18945221 pascalfrancis_primary_21316106 crossref_citationtrail_10_1111_j_1530_0277_2008_00814_x crossref_primary_10_1111_j_1530_0277_2008_00814_x wiley_primary_10_1111_j_1530_0277_2008_00814_x_ACER814 istex_primary_ark_67375_WNG_P0CZZGT0_2 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | January 2009 |
| PublicationDateYYYYMMDD | 2009-01-01 |
| PublicationDate_xml | – month: 01 year: 2009 text: January 2009 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Hoboken, NJ – name: England |
| PublicationTitle | Alcoholism, clinical and experimental research |
| PublicationTitleAlternate | Alcohol Clin Exp Res |
| PublicationYear | 2009 |
| Publisher | Blackwell Publishing Ltd Wiley |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley |
| References | Dodd PR, Beckmann AM, Davidson MS, Wilce PA (2000) Glutamate-mediated transmission, alcohol, and alcoholism. Neurochem Int 37:509-533. Stenbacka M (2003) Problematic alcohol and cannabis use in adolescence - risk of serious adult substance abuse? Drug Alcohol Rev 22:277-286. Greengard P, Valtorta F, Czernik AJ, Benfenati F (1993) Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259:780-785. Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 81:802-813. Alexander-Kaufman K, Harper C, Wilce P, Matsumoto I (2007b) Cerebellar vermis proteome of chronic alcoholic individuals. Alcohol Clin Exp Res 31:1286-1296. Hargreaves GA, McGregor IS (2007) Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats. Alcohol Clin Exp Res 31:1900-1907. Higley JD, Suomi SJ, Linnoila M (1996) A nonhuman primate model of type II excessive alcohol consumption? Part 1. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption. Alcohol Clin Exp Res 20:629-642. Dao-Castellana MH, Samson Y, Legault F, Martinot JL, Aubin HJ, Crouzel C, Feldman L, Barrucand D, Rancurel G, Feline A, Syrota A (1998) Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings. Psychol Med 28:1039-1048. Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A (2005) S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol 7:665-674. Hara MR, Thomas B, Cascio MB, Bae B-I, Hester LD, Dawson VL, Dawson TM, Sawa A, Snyder SH (2006) Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci USA 103:3887-3889. White AM, Ghia AJ, Levin ED, Swartzwelder HS (2000) Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol. Alcohol Clin Exp Res 24:1251-1256. Bora PS, Lange LG (1993) Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esters. Alcohol Clin Exp Res 17:28-30. Subramanian A, Miller DM (2000) Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem 275:5958-5965. Cunningham CC, Ivester P (1999) Chronic ethanol, oxygen tension and hepatocyte energy metabolism. Front Biosci 4:D551-D556. Porrino LJ, Smith HR, Nader MA, Beveridge TJR (2007) The effects of cocaine: a shifting target over the course of addiction. Prog Neuropsychopharmacol Biol Psychiatry 31:1593-1600. Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr (2002) The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell 111:209-218. Alexander-Kaufman K, James G, Sheedy D, Harper C, Matsumoto I (2006) Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Mol Psychiatry 11:56-65. Swartzwelder HS, Wilson WA, Tayyeb MI (1995b) Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 19:320-323. Osaka H, Wang Y-L, Takada K, Takizawa S, Setsuie R, Li H, Sato Y, Nishikawa K, Sun Y-J, Sakurai M, Harada T, Hara Y, Kimura I, Chiba S, Namikawa K, Kiyama H, Noda M, Aoki S, Wada K (2003) Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet 12:1945-1958. Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E, Jerome RE, Lumeng L, Nurnberger JI Jr, Edenberg HJ, McBride WJ, Niculescu AB (2007) Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. Pharmacogenomics J 7:222-256. Sircar R, Sircar D (2005) Adolescent rats exposed to repeated ethanol treatment show lingering behavioral impairments. Alcohol Clin Exp Res 29:1402-1410. Kurihara LJ, Kikuchi T, Wada K, Tilghman SM (2001) Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum Mol Genet 10:1963-1970. Acheson SK, Stein RM, Swartzwelder HS (1998) Impairment of semantic and figural memory by acute ethanol: age-dependent effects. Alcohol Clin Exp Res 22:1437-1442. Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-463. Yasuda Y, Miyamoto Y, Saiwaki T, Yoneda Y (2006) Mechanism of the stress-induced collapse of the Ran distribution. Exp Cell Res 312:512-520. Liu J, Lewohl JM, Harris RA, Dodd PR, Mayfield RD (2007) Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics. Alcohol Clin Exp Res 31:1460-1466. Markwiese BJ, Acheson SK, Levin ED, Wilson WA, Swartzwelder HS (1998) Differential effects of ethanol on memory in adolescent and adult rats. Alcohol Clin Exp Res 22:416-421. Nixon K, Crews FT (2004) Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol. J Neurosci 24:9714-9722. Weissenborn R, Duka T (2003) Acute alcohol effects on cognitive function in social drinkers: their relationship to drinking habits. Psychopharmacology (Berl) 165:306-312. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100:9440-9445. Quinn H, Matsumoto I, Callaghan PD, Long LE, Arnold JC, Gunasekaran N, Thompson MR, Dawson B, Mallet PE, Kashem MA, Matsuda-Matsumoto H, Iwazaki T, McGregor IS (2008). Adolescent rats find repeated D9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology 33:1113-1126. Whitlow CT, Freedland CS, Porrino LJ (2003) Functional consequences of the repeated administration of Delta9-tetrahydrocannabinol in the rat. Drug Alcohol Depend 71:169-177. Yanni PA, Lindsley TA (2000) Ethanol inhibits development of dendrites and synapses in rat hippocampal pyramidal neuron cultures. Brain Res Dev Brain Res 120:233-243. Kashem MA, James G, Harper C, Wilce P, Matsumoto I (2007) Differential protein expression in the corpus callosum (splenium) of human alcoholics: a proteomics study. Neurochem Int 50:450-459. Crews FT, Braun CJ (2003) Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP rats. Alcohol Clin Exp Res 27:1075-1082. Alexander-Kaufman K, Cordwell S, Harper C, Matsumoto I (2007a) A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteom Clin Appl 1:62-72. Matsuda-Matsumoto H, Iwazaki T, Kashem MA, Harper C, Matsumoto I (2007) Differential protein expression profiles in the hippocampus of human alcoholics. Neurochem Int 51:370-376. Iwazaki T, McGregor IS, Matsumoto I (2007) Protein expression profile in the striatum of rats with methamphetamine-induced behavioral sensitization. Proteomics 7:1131-1139. McGregor IS, Gallate JE (2004) Rats on the grog: novel pharmacotherapies for alcohol craving. Addict Behav 29:1341-1357. Nomura F, Tomonaga T, Sogawa K, Wu D, Ohashi T (2007) Application of proteomic technologies to discover and identify biomarkers for excessive alcohol consumption: a review. J Chromatogr B Analyt Technol Biomed Life Sci 855:35-41. Eravci M, Kley S, Pinna G, Prengel H, Brodel O, Hiedra L, Meinhold H, Baumgartner A (1999) Gene expression of glucose transporters and glycolytic enzymes in the CNS of rats behaviorally dependent on ethanol. Brain Res Mol Brain Res 65:103-111. Ferreira A, Rapoport M (2002) The synapsins: beyond the regulation of neurotransmitter release. Cell Mol Life Sci 59:589-595. Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, Mayfield RD (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31:1574-1582. Miller MW, Chiaia NL, Rhoades RW (1990) Intracellular recording and injection study of corticospinal neurons in the rat somatosensory cortex: effect of prenatal exposure to ethanol. J Comp Neurol 297:91-105. Gong B, Cao Z, Zheng P, Vitolo OV, Liu S, Staniszewski A, Moolman D, Zhang H, Shelanski M, Arancio O (2006) Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell 126:775-788. Pitel AL, Beaunieux H, Witkowski T, Vabret F, Guillery-Girard B, Quinette P, Desgranges B, Eustache F (2007) Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence. Alcohol Clin Exp Res 31:1169-1178. Setsuie R, Wada K (2007) The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem Int 51:105-111. Medina KL, Schweinsburg AD, Cohen-Zion M, Nagel BJ, Tapert SF (2007) Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry. Neurotoxicol Teratol 29:141-152. Wiegand G, Remington SJ (1986) Citrate synthase: structure, control, and mechanism. Annu Rev Biophys Biophys Chem 15:97-117. Mayfield RD, Harris RA, Schuckit MA (2008) Genetic factors influencing alcohol dependence. Br J Pharmacol 154:275-287. Cavallaro S, Meiri N, Yi CL, Musco S, Ma W, Goldberg J, Alkon DL (1997) Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Proc Natl Acad Sci USA 94:9669-9673. Blanchard RJ, Hori K, Tom P, Blanchard DC (1987) Social structure and ethanol consumption in the laboratory rat. Pharmacol Biochem Behav 28:437-442. Plaitakis A, Zaganas I (2001) Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain. J Neurosci Res 66:899-908. Medina KL, McQueeny T, Nagel BJ, Hanson KL, Schweinsburg AD, Tapert SF (2008) Prefrontal cortex volu 2002; 59 2006; 30 2006; 31 2004; 29 2002; 111 2004; 24 2004; 4 2007a; 1 2005; 21 2008; 5 2008; 32 2008; 33 2007; 31 2006; 137 1996; 35 2005; 29 1998; 350 2003; 12 2007; 29 2007; 855 1997; 94 1995a; 19 1976; 72 2007; 7 2000; 120 2006; 126 1993; 259 2008; 154 1990; 297 1995b; 19 2007b; 31 1996; 20 2003; 165 2001; 10 1998; 28 2006a; 40 2000; 157 1997; 21 2006; 11 2000; 24 1986; 15 2007 1999; 65 2006; 6 1999; 4 2002; 81 2007; 50 2000; 275 2004 2007; 51 1992; 31 2001; 66 2003; 71 1998; 22 2003; 77 2006; 312 2001; 392 1993; 17 2000; 37 2005; 289 2004; 14 2005; 5 2005; 7 2003; 27 2007; 86 2007; 42 2006b; 83 1998; 5 2004; 117 1987; 28 2003; 100 2006; 103 2003; 22 2005; 58 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_60_1 e_1_2_7_83_1 e_1_2_7_17_1 e_1_2_7_62_1 e_1_2_7_81_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_64_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_66_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_68_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 e_1_2_7_73_1 e_1_2_7_50_1 e_1_2_7_71_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_52_1 e_1_2_7_77_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_54_1 e_1_2_7_75_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_56_1 e_1_2_7_37_1 e_1_2_7_58_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_80_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_61_1 e_1_2_7_82_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_63_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_65_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_67_1 e_1_2_7_48_1 e_1_2_7_69_1 e_1_2_7_27_1 e_1_2_7_29_1 Johnston LD (e_1_2_7_36_1) 2007 e_1_2_7_72_1 e_1_2_7_51_1 e_1_2_7_70_1 e_1_2_7_30_1 e_1_2_7_53_1 e_1_2_7_76_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_55_1 e_1_2_7_74_1 White V (e_1_2_7_79_1) 2004 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_57_1 e_1_2_7_20_1 e_1_2_7_59_1 e_1_2_7_78_1 e_1_2_7_38_1 |
| References_xml | – reference: Bell RL, Rodd ZA, Sable HJK, Schultz JA, Hsu CC, Lumeng L, Murphy JM, McBride WJ (2006b) Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats. Pharmacol Biochem Behav 83:35-46. – reference: Stephens DN, Ripley TL, Borlikova G, Schubert M, Albrecht D, Hogarth L, Duka T (2005) Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus. Biol Psychiatry 58:392-400. – reference: Ferreira A, Rapoport M (2002) The synapsins: beyond the regulation of neurotransmitter release. Cell Mol Life Sci 59:589-595. – reference: Setsuie R, Wada K (2007) The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem Int 51:105-111. – reference: White AM, Ghia AJ, Levin ED, Swartzwelder HS (2000) Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol. Alcohol Clin Exp Res 24:1251-1256. – reference: Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31:119-130. – reference: Kurihara LJ, Kikuchi T, Wada K, Tilghman SM (2001) Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum Mol Genet 10:1963-1970. – reference: Spiess C, Meyer AS, Reissmann S, Frydman J (2004) Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets. Trends Cell Biol 14:598-604. – reference: Dao-Castellana MH, Samson Y, Legault F, Martinot JL, Aubin HJ, Crouzel C, Feldman L, Barrucand D, Rancurel G, Feline A, Syrota A (1998) Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings. Psychol Med 28:1039-1048. – reference: Matsuda-Matsumoto H, Iwazaki T, Kashem MA, Harper C, Matsumoto I (2007) Differential protein expression profiles in the hippocampus of human alcoholics. Neurochem Int 51:370-376. – reference: Mayfield RD, Harris RA, Schuckit MA (2008) Genetic factors influencing alcohol dependence. Br J Pharmacol 154:275-287. – reference: Hara MR, Thomas B, Cascio MB, Bae B-I, Hester LD, Dawson VL, Dawson TM, Sawa A, Snyder SH (2006) Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci USA 103:3887-3889. – reference: Nakamura K, Iwahashi K, Furukawa A, Ameno K, Kinoshita H, Ijiri I, Sekine Y, Suzuki K, Iwata Y, Minabe Y, Mori N (2003) Acetaldehyde adducts in the brain of alcoholics. Arch Toxicol 77:591-593. – reference: Weissenborn R, Duka T (2003) Acute alcohol effects on cognitive function in social drinkers: their relationship to drinking habits. Psychopharmacology (Berl) 165:306-312. – reference: Dougherty MK, Morrison DK (2004) Unlocking the code of 14-3-3. J Cell Sci 117:1875-1884. – reference: Sircar R, Sircar D (2005) Adolescent rats exposed to repeated ethanol treatment show lingering behavioral impairments. Alcohol Clin Exp Res 29:1402-1410. – reference: Bora PS, Lange LG (1993) Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esters. Alcohol Clin Exp Res 17:28-30. – reference: Nixon K, Crews FT (2004) Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol. J Neurosci 24:9714-9722. – reference: Quinn H, Matsumoto I, Callaghan PD, Long LE, Arnold JC, Gunasekaran N, Thompson MR, Dawson B, Mallet PE, Kashem MA, Matsuda-Matsumoto H, Iwazaki T, McGregor IS (2008). Adolescent rats find repeated D9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology 33:1113-1126. – reference: Hargreaves GA, McGregor IS (2007) Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats. Alcohol Clin Exp Res 31:1900-1907. – reference: Cahill A, Hershman S, Davies A, Sykora P (2005) Ethanol feeding enhances age-related deterioration of the rat hepatic mitochondrion. Am J Physiol Gastrointestin Liver Physiol 289:G1115-G1123. – reference: Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A (2005) S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol 7:665-674. – reference: Park B, Jeong S-K, Lee W-S, Seong JK, Paik Y-K (2004) A simple pattern classification method for alcohol-responsive proteins that are differentially expressed in mouse brain. Proteomics 4:3369-3375. – reference: Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 81:802-813. – reference: Baio DL, Czyz CN, Van Horn CG, Ivester P, Cunningham CC (1998) Effect of chronic ethanol consumption on respiratory and glycolytic activities of rat periportal and perivenous hepatocytes. Arch Biochem Biophys 350:193-200. – reference: Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100:9440-9445. – reference: Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254. – reference: Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, Mayfield RD (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31:1574-1582. – reference: Beresford TP, Arciniegas DB, Alfers J, Clapp L, Martin B, Du Y, Liu D, Shen D, Davatzikos C (2006) Hippocampus volume loss due to chronic heavy drinking. Alcohol Clin Exp Res 30:1866-1870. – reference: Glatz JF, Van Der Vusse GJ (1996) Cellular fatty acid-binding proteins: their function and physiological significance. Prog Lipid Res 35:243-282. – reference: Pfefferbaum A, Sullivan EV, Mathalon DH, Lim KO (1997) Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol Clin Exp Res 21:521-529. – reference: Alexander-Kaufman K, Cordwell S, Harper C, Matsumoto I (2007a) A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteom Clin Appl 1:62-72. – reference: Porrino LJ, Smith HR, Nader MA, Beveridge TJR (2007) The effects of cocaine: a shifting target over the course of addiction. Prog Neuropsychopharmacol Biol Psychiatry 31:1593-1600. – reference: Stenbacka M (2003) Problematic alcohol and cannabis use in adolescence - risk of serious adult substance abuse? Drug Alcohol Rev 22:277-286. – reference: Iwazaki T, McGregor IS, Matsumoto I (2007) Protein expression profile in the striatum of rats with methamphetamine-induced behavioral sensitization. Proteomics 7:1131-1139. – reference: Alexander-Kaufman K, Harper C, Wilce P, Matsumoto I (2007b) Cerebellar vermis proteome of chronic alcoholic individuals. Alcohol Clin Exp Res 31:1286-1296. – reference: McGregor IS, Gallate JE (2004) Rats on the grog: novel pharmacotherapies for alcohol craving. Addict Behav 29:1341-1357. – reference: Plaitakis A, Zaganas I (2001) Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain. J Neurosci Res 66:899-908. – reference: Freeman WM, Brebner K, Amara SG, Reed MS, Pohl J, Phillips AG (2005) Distinct proteomic profiles of amphetamine self-administration transitional states. Pharmacogenomics J 5:203-214. – reference: He J, Nixon K, Shetty AK, Crews FT (2005) Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons. Eur J Neurosci 21:2711-2720. – reference: Van Horn CG, Ivester P, Cunningham CC (2001) Chronic ethanol consumption and liver glycogen synthesis. Arch Biochem Biophys 392:145-152. – reference: Miller MW, Chiaia NL, Rhoades RW (1990) Intracellular recording and injection study of corticospinal neurons in the rat somatosensory cortex: effect of prenatal exposure to ethanol. J Comp Neurol 297:91-105. – reference: Sheline CT, Choi DW (1998) Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase. Neurobiol Dis 5:47-54. – reference: Eravci M, Kley S, Pinna G, Prengel H, Brodel O, Hiedra L, Meinhold H, Baumgartner A (1999) Gene expression of glucose transporters and glycolytic enzymes in the CNS of rats behaviorally dependent on ethanol. Brain Res Mol Brain Res 65:103-111. – reference: Crews FT, Mdzinarishvili A, Kim D, He J, Nixon K (2006) Neurogenesis in adolescent brain is potently inhibited by ethanol. Neuroscience 137:437-445. – reference: Kashem MA, James G, Harper C, Wilce P, Matsumoto I (2007) Differential protein expression in the corpus callosum (splenium) of human alcoholics: a proteomics study. Neurochem Int 50:450-459. – reference: Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr (2002) The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell 111:209-218. – reference: De Bellis MD, Clark DB, Beers SR, Soloff PH, Boring AM, Hall J, Kersh A, Keshavan MS (2000) Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 157:737-744. – reference: Orrù A, Lobina C, Maccioni P, Gessa GL, Carai MA, Colombo G (2007) Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in sardinian alcohol-preferring and Sardinian non-preferring rats. Alcohol Alcohol 42:513-524. – reference: Cavallaro S, Meiri N, Yi CL, Musco S, Ma W, Goldberg J, Alkon DL (1997) Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Proc Natl Acad Sci USA 94:9669-9673. – reference: Matsumoto H, Matsumoto I (2008). Alcoholism: protein expression profiles in a human hippocampal model. Expert Rev Proteomics. 5:321-331. – reference: Medina KL, McQueeny T, Nagel BJ, Hanson KL, Schweinsburg AD, Tapert SF (2008) Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. Alcohol Clin Exp Res 32:386-394. – reference: Crews FT, Braun CJ (2003) Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP rats. Alcohol Clin Exp Res 27:1075-1082. – reference: Higley JD, Suomi SJ, Linnoila M (1996) A nonhuman primate model of type II excessive alcohol consumption? Part 1. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption. Alcohol Clin Exp Res 20:629-642. – reference: Crews F, He J, Hodge C (2007) Adolescent cortical development: a critical period of vulnerability for addiction. Pharmacol Biochem Behav 86:189-199. – reference: Yanni PA, Lindsley TA (2000) Ethanol inhibits development of dendrites and synapses in rat hippocampal pyramidal neuron cultures. Brain Res Dev Brain Res 120:233-243. – reference: Bell RL, Kimpel MW, Rodd ZA, Strother WN, Bai F, Peper CL, Mayfield RD, Lumeng L, Crabb DW, McBride WJ, Witzmann FA (2006a) Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol. Alcohol 40:3-17. – reference: Greengard P, Valtorta F, Czernik AJ, Benfenati F (1993) Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259:780-785. – reference: Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E, Jerome RE, Lumeng L, Nurnberger JI Jr, Edenberg HJ, McBride WJ, Niculescu AB (2007) Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. Pharmacogenomics J 7:222-256. – reference: Sari Y, Bell RL, Zhou FC (2006) Effects of chronic alcohol and repeated deprivations on dopamine D1 and D2 receptor levels in the extended amygdala of inbred alcohol-preferring rats. Alcohol Clin Exp Res 30:46-56. – reference: Osaka H, Wang Y-L, Takada K, Takizawa S, Setsuie R, Li H, Sato Y, Nishikawa K, Sun Y-J, Sakurai M, Harada T, Hara Y, Kimura I, Chiba S, Namikawa K, Kiyama H, Noda M, Aoki S, Wada K (2003) Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet 12:1945-1958. – reference: Markwiese BJ, Acheson SK, Levin ED, Wilson WA, Swartzwelder HS (1998) Differential effects of ethanol on memory in adolescent and adult rats. Alcohol Clin Exp Res 22:416-421. – reference: Medina KL, Schweinsburg AD, Cohen-Zion M, Nagel BJ, Tapert SF (2007) Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry. Neurotoxicol Teratol 29:141-152. – reference: Wiegand G, Remington SJ (1986) Citrate synthase: structure, control, and mechanism. Annu Rev Biophys Biophys Chem 15:97-117. – reference: Subramanian A, Miller DM (2000) Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem 275:5958-5965. – reference: Swartzwelder HS, Wilson WA, Tayyeb MI (1995b) Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 19:320-323. – reference: Whitlow CT, Freedland CS, Porrino LJ (2003) Functional consequences of the repeated administration of Delta9-tetrahydrocannabinol in the rat. Drug Alcohol Depend 71:169-177. – reference: Gong B, Cao Z, Zheng P, Vitolo OV, Liu S, Staniszewski A, Moolman D, Zhang H, Shelanski M, Arancio O (2006) Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell 126:775-788. – reference: Nomura F, Tomonaga T, Sogawa K, Wu D, Ohashi T (2007) Application of proteomic technologies to discover and identify biomarkers for excessive alcohol consumption: a review. J Chromatogr B Analyt Technol Biomed Life Sci 855:35-41. – reference: Acheson SK, Stein RM, Swartzwelder HS (1998) Impairment of semantic and figural memory by acute ethanol: age-dependent effects. Alcohol Clin Exp Res 22:1437-1442. – reference: Klouckova I, Hrncirova P, Mechref Y, Arnold RJ, Li T-K, McBride WJ, Novotny MV (2006) Changes in liver protein abundance in inbred alcohol-preferring rats due to chronic alcohol exposure, as measured through a proteomics approach. Proteomics 6:3060-3074. – reference: Alexander-Kaufman K, James G, Sheedy D, Harper C, Matsumoto I (2006) Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Mol Psychiatry 11:56-65. – reference: Swartzwelder HS, Wilson WA, Tayyeb MI (1995a) Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 19:1480-1485. – reference: Pitel AL, Beaunieux H, Witkowski T, Vabret F, Guillery-Girard B, Quinette P, Desgranges B, Eustache F (2007) Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence. Alcohol Clin Exp Res 31:1169-1178. – reference: Liu J, Lewohl JM, Harris RA, Dodd PR, Mayfield RD (2007) Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics. Alcohol Clin Exp Res 31:1460-1466. – reference: Dodd PR, Beckmann AM, Davidson MS, Wilce PA (2000) Glutamate-mediated transmission, alcohol, and alcoholism. Neurochem Int 37:509-533. – reference: Blanchard RJ, Hori K, Tom P, Blanchard DC (1987) Social structure and ethanol consumption in the laboratory rat. Pharmacol Biochem Behav 28:437-442. – reference: Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-463. – reference: Yasuda Y, Miyamoto Y, Saiwaki T, Yoneda Y (2006) Mechanism of the stress-induced collapse of the Ran distribution. Exp Cell Res 312:512-520. – reference: Cunningham CC, Ivester P (1999) Chronic ethanol, oxygen tension and hepatocyte energy metabolism. Front Biosci 4:D551-D556. – volume: 24 start-page: 1251 year: 2000 end-page: 1256 article-title: Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol publication-title: Alcohol Clin Exp Res – volume: 22 start-page: 1437 year: 1998 end-page: 1442 article-title: Impairment of semantic and figural memory by acute ethanol: age‐dependent effects publication-title: Alcohol Clin Exp Res – volume: 22 start-page: 416 year: 1998 end-page: 421 article-title: Differential effects of ethanol on memory in adolescent and adult rats publication-title: Alcohol Clin Exp Res – volume: 66 start-page: 899 year: 2001 end-page: 908 article-title: Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain publication-title: J Neurosci Res – volume: 350 start-page: 193 year: 1998 end-page: 200 article-title: Effect of chronic ethanol consumption on respiratory and glycolytic activities of rat periportal and perivenous hepatocytes publication-title: Arch Biochem Biophys – volume: 31 start-page: 1286 year: 2007b end-page: 1296 article-title: Cerebellar vermis proteome of chronic alcoholic individuals publication-title: Alcohol Clin Exp Res – volume: 5 start-page: 47 year: 1998 end-page: 54 article-title: Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase publication-title: Neurobiol Dis – volume: 1 start-page: 62 year: 2007a end-page: 72 article-title: A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients publication-title: Proteom Clin Appl – volume: 103 start-page: 3887 year: 2006 end-page: 3889 article-title: Neuroprotection by pharmacologic blockade of the GAPDH death cascade publication-title: Proc Natl Acad Sci USA – volume: 31 start-page: 119 year: 1992 end-page: 130 article-title: Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? publication-title: Ann Neurol – volume: 12 start-page: 1945 year: 2003 end-page: 1958 article-title: Ubiquitin carboxy‐terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron publication-title: Hum Mol Genet – volume: 7 start-page: 665 year: 2005 end-page: 674 article-title: S‐nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding publication-title: Nat Cell Biol – volume: 10 start-page: 1963 year: 2001 end-page: 1970 article-title: Loss of Uch‐L1 and Uch‐L3 leads to neurodegeneration, posterior paralysis and dysphagia publication-title: Hum Mol Genet – volume: 7 start-page: 222 year: 2007 end-page: 256 article-title: Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach publication-title: Pharmacogenomics J – volume: 71 start-page: 169 year: 2003 end-page: 177 article-title: Functional consequences of the repeated administration of Delta9‐tetrahydrocannabinol in the rat publication-title: Drug Alcohol Depend – volume: 29 start-page: 1402 year: 2005 end-page: 1410 article-title: Adolescent rats exposed to repeated ethanol treatment show lingering behavioral impairments publication-title: Alcohol Clin Exp Res – volume: 157 start-page: 737 year: 2000 end-page: 744 article-title: Hippocampal volume in adolescent‐onset alcohol use disorders publication-title: Am J Psychiatry – volume: 5 start-page: 321 year: 2008 end-page: 331 article-title: Alcoholism: protein expression profiles in a human hippocampal model publication-title: Expert Rev Proteomics – volume: 117 start-page: 1875 year: 2004 end-page: 1884 article-title: Unlocking the code of 14‐3‐3 publication-title: J Cell Sci – volume: 392 start-page: 145 year: 2001 end-page: 152 article-title: Chronic ethanol consumption and liver glycogen synthesis publication-title: Arch Biochem Biophys – volume: 165 start-page: 306 year: 2003 end-page: 312 article-title: Acute alcohol effects on cognitive function in social drinkers: their relationship to drinking habits publication-title: Psychopharmacology (Berl) – volume: 111 start-page: 209 year: 2002 end-page: 218 article-title: The UCH‐L1 gene encodes two opposing enzymatic activities that affect alpha‐synuclein degradation and Parkinson’s disease susceptibility publication-title: Cell – volume: 15 start-page: 97 year: 1986 end-page: 117 article-title: Citrate synthase: structure, control, and mechanism publication-title: Annu Rev Biophys Biophys Chem – volume: 28 start-page: 1039 year: 1998 end-page: 1048 article-title: Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings publication-title: Psychol Med – volume: 33 start-page: 1113 year: 2008 end-page: 1126 article-title: Adolescent rats find repeated D9‐THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure publication-title: Neuropsychopharmacology – volume: 58 start-page: 392 year: 2005 end-page: 400 article-title: Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long‐term potentiation in rat amygdala and hippocampus publication-title: Biol Psychiatry – volume: 120 start-page: 233 year: 2000 end-page: 243 article-title: Ethanol inhibits development of dendrites and synapses in rat hippocampal pyramidal neuron cultures publication-title: Brain Res Dev Brain Res – volume: 30 start-page: 46 year: 2006 end-page: 56 article-title: Effects of chronic alcohol and repeated deprivations on dopamine D1 and D2 receptor levels in the extended amygdala of inbred alcohol‐preferring rats publication-title: Alcohol Clin Exp Res – volume: 7 start-page: 1131 year: 2007 end-page: 1139 article-title: Protein expression profile in the striatum of rats with methamphetamine‐induced behavioral sensitization publication-title: Proteomics – volume: 5 start-page: 203 year: 2005 end-page: 214 article-title: Distinct proteomic profiles of amphetamine self‐administration transitional states publication-title: Pharmacogenomics J – volume: 35 start-page: 243 year: 1996 end-page: 282 article-title: Cellular fatty acid‐binding proteins: their function and physiological significance publication-title: Prog Lipid Res – volume: 154 start-page: 275 year: 2008 end-page: 287 article-title: Genetic factors influencing alcohol dependence publication-title: Br J Pharmacol – volume: 4 start-page: D551 year: 1999 end-page: D556 article-title: Chronic ethanol, oxygen tension and hepatocyte energy metabolism publication-title: Front Biosci – year: 2004 – volume: 81 start-page: 802 year: 2002 end-page: 813 article-title: Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics publication-title: J Neurochem – volume: 22 start-page: 277 year: 2003 end-page: 286 article-title: Problematic alcohol and cannabis use in adolescence ‐ risk of serious adult substance abuse? publication-title: Drug Alcohol Rev – volume: 51 start-page: 370 year: 2007 end-page: 376 article-title: Differential protein expression profiles in the hippocampus of human alcoholics publication-title: Neurochem Int – volume: 17 start-page: 28 year: 1993 end-page: 30 article-title: Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esters publication-title: Alcohol Clin Exp Res – volume: 275 start-page: 5958 year: 2000 end-page: 5965 article-title: Structural analysis of alpha‐enolase. Mapping the functional domains involved in down‐regulation of the c‐myc protooncogene publication-title: J Biol Chem – volume: 14 start-page: 598 year: 2004 end-page: 604 article-title: Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets publication-title: Trends Cell Biol – volume: 11 start-page: 56 year: 2006 end-page: 65 article-title: Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study publication-title: Mol Psychiatry – volume: 31 start-page: 1593 year: 2007 end-page: 1600 article-title: The effects of cocaine: a shifting target over the course of addiction publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 72 start-page: 248 year: 1976 end-page: 254 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein‐dye binding publication-title: Anal Biochem – volume: 94 start-page: 9669 year: 1997 end-page: 9673 article-title: Late memory‐related genes in the hippocampus revealed by RNA fingerprinting publication-title: Proc Natl Acad Sci USA – volume: 37 start-page: 509 year: 2000 end-page: 533 article-title: Glutamate‐mediated transmission, alcohol, and alcoholism publication-title: Neurochem Int – volume: 312 start-page: 512 year: 2006 end-page: 520 article-title: Mechanism of the stress‐induced collapse of the Ran distribution publication-title: Exp Cell Res – volume: 30 start-page: 1866 year: 2006 end-page: 1870 article-title: Hippocampus volume loss due to chronic heavy drinking publication-title: Alcohol Clin Exp Res – volume: 21 start-page: 2711 year: 2005 end-page: 2720 article-title: Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons publication-title: Eur J Neurosci – year: 2007 – volume: 289 start-page: G1115 year: 2005 end-page: G1123 article-title: Ethanol feeding enhances age‐related deterioration of the rat hepatic mitochondrion publication-title: Am J Physiol Gastrointestin Liver Physiol – volume: 137 start-page: 437 year: 2006 end-page: 445 article-title: Neurogenesis in adolescent brain is potently inhibited by ethanol publication-title: Neuroscience – volume: 24 start-page: 9714 year: 2004 end-page: 9722 article-title: Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol publication-title: J Neurosci – volume: 19 start-page: 1480 year: 1995a end-page: 1485 article-title: Age‐dependent inhibition of long‐term potentiation by ethanol in immature versus mature hippocampus publication-title: Alcohol Clin Exp Res – volume: 65 start-page: 103 year: 1999 end-page: 111 article-title: Gene expression of glucose transporters and glycolytic enzymes in the CNS of rats behaviorally dependent on ethanol publication-title: Brain Res Mol Brain Res – volume: 126 start-page: 775 year: 2006 end-page: 788 article-title: Ubiquitin hydrolase Uch‐L1 rescues beta‐amyloid‐induced decreases in synaptic function and contextual memory publication-title: Cell – volume: 20 start-page: 629 year: 1996 end-page: 642 article-title: A nonhuman primate model of type II excessive alcohol consumption? Part 1. Low cerebrospinal fluid 5‐hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption publication-title: Alcohol Clin Exp Res – volume: 77 start-page: 591 year: 2003 end-page: 593 article-title: Acetaldehyde adducts in the brain of alcoholics publication-title: Arch Toxicol – volume: 86 start-page: 189 year: 2007 end-page: 199 article-title: Adolescent cortical development: a critical period of vulnerability for addiction publication-title: Pharmacol Biochem Behav – volume: 259 start-page: 780 year: 1993 end-page: 785 article-title: Synaptic vesicle phosphoproteins and regulation of synaptic function publication-title: Science – volume: 297 start-page: 91 year: 1990 end-page: 105 article-title: Intracellular recording and injection study of corticospinal neurons in the rat somatosensory cortex: effect of prenatal exposure to ethanol publication-title: J Comp Neurol – volume: 42 start-page: 513 year: 2007 end-page: 524 article-title: Repeated exposure to alcoholic beer does not induce long‐lasting changes in alcohol self‐administration and intake in sardinian alcohol‐preferring and Sardinian non‐preferring rats publication-title: Alcohol Alcohol – volume: 28 start-page: 437 year: 1987 end-page: 442 article-title: Social structure and ethanol consumption in the laboratory rat publication-title: Pharmacol Biochem Behav – volume: 855 start-page: 35 year: 2007 end-page: 41 article-title: Application of proteomic technologies to discover and identify biomarkers for excessive alcohol consumption: a review publication-title: J Chromatogr B Analyt Technol Biomed Life Sci – volume: 100 start-page: 9440 year: 2003 end-page: 9445 article-title: Statistical significance for genomewide studies publication-title: Proc Natl Acad Sci USA – volume: 83 start-page: 35 year: 2006b end-page: 46 article-title: Daily patterns of ethanol drinking in peri‐adolescent and adult alcohol‐preferring (P) rats publication-title: Pharmacol Biochem Behav – volume: 6 start-page: 3060 year: 2006 end-page: 3074 article-title: Changes in liver protein abundance in inbred alcohol‐preferring rats due to chronic alcohol exposure, as measured through a proteomics approach publication-title: Proteomics – volume: 31 start-page: 1169 year: 2007 end-page: 1178 article-title: Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence publication-title: Alcohol Clin Exp Res – volume: 4 start-page: 3369 year: 2004 end-page: 3375 article-title: A simple pattern classification method for alcohol‐responsive proteins that are differentially expressed in mouse brain publication-title: Proteomics – volume: 21 start-page: 521 year: 1997 end-page: 529 article-title: Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics publication-title: Alcohol Clin Exp Res – volume: 24 start-page: 417 year: 2000 end-page: 463 article-title: The adolescent brain and age‐related behavioral manifestations publication-title: Neurosci Biobehav Rev – volume: 31 start-page: 1460 year: 2007 end-page: 1466 article-title: Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics publication-title: Alcohol Clin Exp Res – volume: 32 start-page: 386 year: 2008 end-page: 394 article-title: Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects publication-title: Alcohol Clin Exp Res – volume: 19 start-page: 320 year: 1995b end-page: 323 article-title: Differential sensitivity of NMDA receptor‐mediated synaptic potentials to ethanol in immature versus mature hippocampus publication-title: Alcohol Clin Exp Res – volume: 40 start-page: 3 year: 2006a end-page: 17 article-title: Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol‐preferring rats given either continuous or scheduled access to ethanol publication-title: Alcohol – volume: 31 start-page: 1900 year: 2007 end-page: 1907 article-title: Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats publication-title: Alcohol Clin Exp Res – volume: 27 start-page: 1075 year: 2003 end-page: 1082 article-title: Binge ethanol treatment causes greater brain damage in alcohol‐preferring P rats than in alcohol‐nonpreferring NP rats publication-title: Alcohol Clin Exp Res – volume: 29 start-page: 141 year: 2007 end-page: 152 article-title: Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry publication-title: Neurotoxicol Teratol – volume: 59 start-page: 589 year: 2002 end-page: 595 article-title: The synapsins: beyond the regulation of neurotransmitter release publication-title: Cell Mol Life Sci – volume: 50 start-page: 450 year: 2007 end-page: 459 article-title: Differential protein expression in the corpus callosum (splenium) of human alcoholics: a proteomics study publication-title: Neurochem Int – volume: 31 start-page: 1574 year: 2006 end-page: 1582 article-title: Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals publication-title: Neuropsychopharmacology – volume: 29 start-page: 1341 year: 2004 end-page: 1357 article-title: Rats on the grog: novel pharmacotherapies for alcohol craving publication-title: Addict Behav – volume: 51 start-page: 105 year: 2007 end-page: 111 article-title: The functions of UCH‐L1 and its relation to neurodegenerative diseases publication-title: Neurochem Int – ident: e_1_2_7_41_1 doi: 10.1111/j.1530-0277.2007.00444.x – ident: e_1_2_7_63_1 doi: 10.1038/sj.tpj.6500420 – ident: e_1_2_7_77_1 doi: 10.1007/s00213-002-1281-1 – ident: e_1_2_7_16_1 doi: 10.1097/01.ALC.0000075826.35688.0D – ident: e_1_2_7_25_1 doi: 10.1007/s00018-002-8451-5 – ident: e_1_2_7_65_1 doi: 10.1016/j.neuint.2007.05.007 – ident: e_1_2_7_45_1 doi: 10.1586/14789450.5.2.321 – ident: e_1_2_7_40_1 doi: 10.1016/S0092-8674(02)01012-7 – volume-title: NIH Publication No. 07‐6202 year: 2007 ident: e_1_2_7_36_1 – ident: e_1_2_7_70_1 doi: 10.1080/0959523031000154418 – ident: e_1_2_7_43_1 doi: 10.1111/j.1530-0277.1998.tb03668.x – ident: e_1_2_7_71_1 doi: 10.1016/j.biopsych.2005.04.025 – ident: e_1_2_7_18_1 doi: 10.1016/j.neuroscience.2005.08.090 – ident: e_1_2_7_66_1 doi: 10.1006/nbdi.1998.0177 – ident: e_1_2_7_21_1 doi: 10.1176/appi.ajp.157.5.737 – ident: e_1_2_7_34_1 doi: 10.1111/j.1530-0277.1996.tb01665.x – ident: e_1_2_7_44_1 doi: 10.1016/j.neuint.2007.04.001 – ident: e_1_2_7_29_1 doi: 10.1126/science.8430330 – ident: e_1_2_7_53_1 doi: 10.1523/JNEUROSCI.3063-04.2004 – ident: e_1_2_7_17_1 doi: 10.1016/j.pbb.2006.12.001 – ident: e_1_2_7_62_1 doi: 10.1038/sj.npp.1301475 – ident: e_1_2_7_2_1 doi: 10.1111/j.1530-0277.1998.tb03932.x – ident: e_1_2_7_55_1 doi: 10.1093/alcalc/agm067 – ident: e_1_2_7_82_1 doi: 10.1016/S0165-3806(00)00015-8 – ident: e_1_2_7_14_1 doi: 10.1152/ajpgi.00193.2005 – ident: e_1_2_7_61_1 doi: 10.1016/j.pnpbp.2007.08.040 – ident: e_1_2_7_4_1 doi: 10.1111/j.1530-0277.2007.00437.x – ident: e_1_2_7_15_1 doi: 10.1073/pnas.94.18.9669 – ident: e_1_2_7_64_1 doi: 10.1111/j.1530-0277.2006.00010.x – ident: e_1_2_7_20_1 doi: 10.1017/S0033291798006849 – ident: e_1_2_7_9_1 doi: 10.1016/j.pbb.2005.12.004 – ident: e_1_2_7_81_1 doi: 10.1146/annurev.bb.15.060186.000525 – ident: e_1_2_7_51_1 doi: 10.1002/cne.902970107 – ident: e_1_2_7_8_1 doi: 10.1016/j.alcohol.2006.10.001 – ident: e_1_2_7_69_1 doi: 10.1016/j.tcb.2004.09.015 – ident: e_1_2_7_13_1 doi: 10.1016/0003-2697(76)90527-3 – ident: e_1_2_7_56_1 doi: 10.1093/hmg/ddg211 – ident: e_1_2_7_38_1 doi: 10.1002/pmic.200500725 – ident: e_1_2_7_24_1 doi: 10.1016/S0169-328X(98)00347-7 – ident: e_1_2_7_46_1 doi: 10.1038/bjp.2008.88 – ident: e_1_2_7_52_1 doi: 10.1007/s00204-003-0465-8 – ident: e_1_2_7_67_1 doi: 10.1097/01.alc.0000175012.77756.d9 – ident: e_1_2_7_80_1 doi: 10.1016/S0376-8716(03)00135-2 – ident: e_1_2_7_37_1 doi: 10.1016/j.neuint.2006.10.009 – ident: e_1_2_7_59_1 doi: 10.1111/j.1530-0277.2007.00418.x – ident: e_1_2_7_26_1 doi: 10.1038/sj.tpj.6500309 – ident: e_1_2_7_47_1 doi: 10.1046/j.1471-4159.2002.00860.x – ident: e_1_2_7_3_1 doi: 10.1002/prca.200600417 – ident: e_1_2_7_60_1 doi: 10.1002/jnr.10054 – ident: e_1_2_7_11_1 doi: 10.1016/0091-3057(87)90502-8 – ident: e_1_2_7_54_1 doi: 10.1016/j.jchromb.2007.05.023 – ident: e_1_2_7_12_1 doi: 10.1111/j.1530-0277.1993.tb00721.x – ident: e_1_2_7_42_1 doi: 10.1038/sj.npp.1300947 – ident: e_1_2_7_48_1 doi: 10.1016/j.addbeh.2004.06.011 – ident: e_1_2_7_49_1 doi: 10.1111/j.1530-0277.2007.00602.x – ident: e_1_2_7_22_1 doi: 10.1016/S0197-0186(00)00061-9 – ident: e_1_2_7_31_1 doi: 10.1073/pnas.0511321103 – ident: e_1_2_7_19_1 doi: 10.2741/Cunning – ident: e_1_2_7_58_1 doi: 10.1111/j.1530-0277.1997.tb03798.x – ident: e_1_2_7_28_1 doi: 10.1016/j.cell.2006.06.046 – ident: e_1_2_7_72_1 doi: 10.1073/pnas.1530509100 – ident: e_1_2_7_6_1 doi: 10.1006/abbi.1997.0514 – ident: e_1_2_7_78_1 doi: 10.1111/j.1530-0277.2000.tb02091.x – ident: e_1_2_7_5_1 doi: 10.1038/sj.mp.4001741 – ident: e_1_2_7_7_1 doi: 10.1002/ana.410310202 – ident: e_1_2_7_39_1 doi: 10.1093/hmg/10.18.1963 – ident: e_1_2_7_10_1 doi: 10.1111/j.1530-0277.2006.00223.x – ident: e_1_2_7_23_1 doi: 10.1242/jcs.01171 – ident: e_1_2_7_33_1 doi: 10.1111/j.1460-9568.2005.04120.x – ident: e_1_2_7_35_1 doi: 10.1002/pmic.200600595 – ident: e_1_2_7_68_1 doi: 10.1016/S0149-7634(00)00014-2 – ident: e_1_2_7_76_1 doi: 10.1006/abbi.2001.2433 – ident: e_1_2_7_27_1 doi: 10.1016/S0163-7827(96)00006-9 – ident: e_1_2_7_75_1 doi: 10.1111/j.1530-0277.1995.tb01509.x – ident: e_1_2_7_50_1 doi: 10.1016/j.ntt.2006.10.010 – ident: e_1_2_7_83_1 doi: 10.1016/j.yexcr.2005.11.017 – ident: e_1_2_7_57_1 doi: 10.1002/pmic.200400958 – ident: e_1_2_7_73_1 doi: 10.1074/jbc.275.8.5958 – ident: e_1_2_7_32_1 doi: 10.1111/j.1530-0277.2007.00485.x – ident: e_1_2_7_30_1 doi: 10.1038/ncb1268 – ident: e_1_2_7_74_1 doi: 10.1111/j.1530-0277.1995.tb01011.x – volume-title: National Drug Strategy Monograph Series No. 55 year: 2004 ident: e_1_2_7_79_1 |
| SSID | ssj0004866 |
| Score | 2.1178055 |
| Snippet | Background: Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim... Background: Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim... Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of the present... Background:Excessive teenage alcohol consumption is of great concern because alcohol may adversely alter the developmental trajectory of the brain. The aim of... |
| SourceID | proquest pubmed pascalfrancis crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 86 |
| SubjectTerms | Aging - drug effects Aging - metabolism Aging - pathology Alcohol Alcohol Drinking - metabolism Alcohol Drinking - pathology Alcohol Drinking - physiopathology Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Brain Chemistry - drug effects Brain Chemistry - physiology Disease Susceptibility - chemically induced Disease Susceptibility - metabolism Disease Susceptibility - physiopathology Glycolysis Hippocampus Hippocampus - chemistry Hippocampus - drug effects Hippocampus - physiopathology Male Medical sciences Proteome Proteomics - methods Rats Rats, Wistar Toxicology Wistar Rat |
| Title | Proteomic Analysis Demonstrates Adolescent Vulnerability to Lasting Hippocampal Changes Following Chronic Alcohol Consumption |
| URI | https://api.istex.fr/ark:/67375/WNG-P0CZZGT0-2/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1530-0277.2008.00814.x https://www.ncbi.nlm.nih.gov/pubmed/18945221 https://www.proquest.com/docview/20286210 https://www.proquest.com/docview/66803817 |
| Volume | 33 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9MwFLbQuHDh94_AGD6g3VI5Tuw4x6qsqxBM07SxaRfLdhxpammqphUDif8dPzvJCBrShLhFSV8bvz7bn-3vfQ-h94XKjLKw_0UZjTNT8FiwUsWpLnlm05LYEhKcPx_x2Vn28YJdtPwnyIUJ-hD9hhv0DD9eQwdXuhl2cpYSfwbZUSJFko0ATwJ1C_DRyY2SVCbCsWWSsdjN8WJI6rn1iwYz1X1w-jUwJ1XjnFeFqhe3wdIhyvXT1PQRmncNDOyU-Wi70SPz4w_tx__jgcfoYYtm8TiE3xN0zy6fot2Q8ovP7aJSa4v3cXejXs-foZ_HIA0BydC4U0TBH-xXwKkgW9HgcS8yhb9sF6CK7Qm83_Gmxp9UAzxtPLtardws7MayBQ4JEg2eupCuv8HTVvEXj0P9XzzxeaZ-cHyOzqYHp5NZ3BaBiA1zYC_mVWJVLtwqVOvKVjoRnOhSkYIqJhzeLHJicmETUVDDhKWKK3eHVoamtsyrPH2Bdpb10r5CWAHVVlmrWMqzqqiKkjErSG5KQUqtdYTy7g-XplVIh0IdC_nbSsl5XILH2_qd4HF5HaGkt1wFlZA72Oz7mOoN1HoOLLucyfOjQ3lMJpeXh6dE0gjtDYKuN6BJ6vA64RF610WhdIMDnPiopa23jfs96lasCfn7JzgXXqQxQi9D-N68vyhAbT-JEPdBeOeGyfHk4MRdvf5XwzfoQTizg42uXbSzWW_tWwf9NnrPd-pfHitK7Q |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6V9gAX3g9DafcAvTlar73r9YFDlDZNaRpVVUqrXszaXksoIYniRE2R-GX8FX4MO147JahIFVIP3CInkzg7D3-zO_MNwLtIBanSuP_FOHODNBKu5Jly_SQTgfYzqjNscD7qic5p8PGcn6_Bj7oXxvJDLDfc0DPKeI0OjhvSq17OfVoeQtY1kdILGouqwvJQX12a_K34cLBrlP2esfZev9VxqxEDbsoNlHBF7mkVSpPjJEmu88STgiaZohFTXBo0E4U0DaX2ZMRSLjVTQpkrLE-Zr7MwD33zvfdgAweKI3H_7sk1d1Ug7UGpF3DXoAq5WkZ0452vPBs3UM0LrNVUhVFXbuds3ASEV3F1-WBsP4Kf9ZLaephBYz5LGum3P9gm_9M1fwwPK8BOmtbDnsCaHj2FTdvVTM70MFdTTXZIfWE8HTyD78fIfoH93qQmfSG7-itCcWTmKEhzyaNFPs2HSPxd1ihfkdmYdFWBpeik82UyMUDDhOshsT0gBWkbrx1f4rsVqTFp2hHHpFW20pbx_zmc3smCvID10XikXwFRWE2stFbcF0Ee5VHGuZY0TDNJsyRJHAhrC4vTigQeZ5EM49-SQaPhGDVcjShFDccLB7yl5MQSodxCZqc04qWAmg6wkDDk8VlvPz6mrYuL_T6NmQNbK1a-FGCeb1ISKhzYrs0-NvEPD7XUSI_nhfk9ZpJyj_79E0LIkofSgZfWX67vX0Y4UMBzQJRWf-s_Fjdbeyfm1et_FdyG-53-UTfuHvQO38ADe0SJ-3qbsD6bzvVbg3RnyVYZUQh8vmt3-gVW1KjS |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VVkJceD8Mpd0D9OZovfau1wcOUdI0pSWKqpZWvbhrey2hhCSKEzVF4o_xV_gz7HjtlKAiVUg9cIucTOLsPPzN7sw3AO8iFaRK4_4X48wN0ki4kmfK9ZNMBNrPqM6wwflTT3RPgo9n_GwNftS9MJYfYrnhhp5Rxmt08EmWrzo592l5BlmXREovaCyqAssDfXVp0rfiw37b6Po9Y53d41bXrSYMuCk3SMIVuadVKE2KkyS5zhNPCppkikZMcWnATBTSNJTakxFLudRMCWWusDxlvs7CPPTN996DjUDQCMdGtI-uqasCac9JvYC7BlTI1SqiG-985dG4gVpeYKmmKoy2cjtm4yYcvAqry-di5xH8rFfUlsMMGvNZ0ki__UE2-X8u-WN4WMF10rT-9QTW9OgpbNqeZnKqh7maarJD6gvj6eAZfO8j9wV2e5Oa8oW09VcE4sjLUZDmkkWLfJ4Pkfa7rFC-IrMxOVQFFqKT7pfJxMAME6yHxHaAFKRjfHZ8ie9WlMakaQcck1bZSFtG_-dwcicL8gLWR-ORfgVEYS2x0lpxXwR5lEcZ51rSMM0kzZIkcSCsDSxOKwp4nEQyjH9LBY2GY9RwNaAUNRwvHPCWkhNLg3ILmZ3ShpcCajrAMsKQx6e9vbhPW-fne8c0Zg5srRj5UoB5vklIqHBgu7b62EQ_PNJSIz2eF-b3mEnJPfr3TwghSxZKB15ad7m-fxnhOAHPAVEa_a3_WNxs7R6ZV6__VXAb7vfbnfhwv3fwBh7Y80nc1NuE9dl0rt8amDtLtsp4QuDirr3pF5b4p4E |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Proteomic+Analysis+Demonstrates+Adolescent+Vulnerability+to+Lasting+Hippocampal+Changes+Following+Chronic+Alcohol+Consumption&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.au=Hargreaves%2C+Garth+A&rft.au=Quinn%2C+Heidi&rft.au=Kashem%2C+Mohammed+A&rft.au=Matsumoto%2C+Izuru&rft.date=2009-01-01&rft.issn=0145-6008&rft.eissn=1530-0277&rft.volume=33&rft.spage=86&rft.epage=94&rft_id=info:doi/10.1111%2Fj.1530-0277.2008.00814.x&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0145-6008&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0145-6008&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0145-6008&client=summon |