Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes

• Published in: Fundamental & clinical pharmacology Vol. 18; no. 5; pp. 531 - 538
• Main Authors: D'Anglemont De Tassigny, Alexandra, Souktani, Rachid, Henry, Patrick, Ghaleh, Bijan, Berdeaux, Alain
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2004; Blackwell; Wiley
• Subjects: Ageing, cell death; Animals; Annexin A5 - metabolism; Antineoplastic Agents - pharmacology; apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Biological and medical sciences; Caspase 3; Caspases - metabolism; Cell membranes. Ionic channels. Membrane pores; Cell physiology; Cell Size - drug effects; Cell structures and functions; cell volume; Cells, Cultured; chloride channel; Chloride Channels - physiology; Doxorubicin - pharmacology; Fundamental and applied biological sciences. Psychology; Heart Ventricles - cytology; Life Sciences; Male; Molecular and cellular biology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - physiology; Osmotic Pressure; Patch-Clamp Techniques; Rabbits; Sphingosine - analogs & derivatives; Sphingosine - pharmacology; Time Factors; Antineoplastic agent; DNA topoisomerase (ATP-hydrolysing); Enzyme; Enzyme inhibitor; Ionic channel; Doxorubicin; Antibiotic; Isomerases; Cell death; chloride channel; Chlorides; Anthracyclins; Cell volume; Apoptosis

Apoptosis is associated with early changes in cell volume through a mechanism called apoptotic volume decrease (AVD). As volume‐sensitive chloride channels (ICl,vol) are known to play a key role in the regulation of cell volume, this study investigated the role of ICl,vol and AVD in doxorubicin‐indu...