Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects
Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, var...
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| Published in | Immunity, Inflammation and Disease Vol. 11; no. 1; pp. e762 - n/a |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
John Wiley & Sons, Inc
01.01.2023
John Wiley and Sons Inc Wiley |
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| Online Access | Get full text |
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| Abstract | Background
Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease.
Methods
This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.
Results
IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis.
Conclusion
This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments.
Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes, focusing on the role of signaling pathways. This article also briefly describes the potential of signal pathway‐targeted therapy in the prevention and treatment of disease, using the application of signal pathways in the treatment of disc degeneration and osteoarthritis as examples. |
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| AbstractList | Abstract
Background
Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease.
Methods
This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.
Results
IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐
k
B signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis.
Conclusion
This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes, focusing on the role of signaling pathways. This article also briefly describes the potential of signal pathway‐targeted therapy in the prevention and treatment of disease, using the application of signal pathways in the treatment of disc degeneration and osteoarthritis as examples. Abstract Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease. Methods This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. Results IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis. Conclusion This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease. This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. IL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis. This review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease. Methods This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. Results IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis. Conclusion This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes, focusing on the role of signaling pathways. This article also briefly describes the potential of signal pathway‐targeted therapy in the prevention and treatment of disease, using the application of signal pathways in the treatment of disc degeneration and osteoarthritis as examples. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease.BACKGROUNDInterleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease.This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.METHODSThis is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.IL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis.RESULTSIL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis.This review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments.CONCLUSIONThis review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. BackgroundInterleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease.MethodsThis is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of “IL-1β-induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.ResultsIL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis.ConclusionThis review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. |
| Author | Xiao, Manxue Qian, Hong Lv, Jingwen Wang, Peixuan |
| AuthorAffiliation | 1 Department of Pediatric Dentistry, Stomatological Hospital Southern Medical University Guangzhou China |
| AuthorAffiliation_xml | – name: 1 Department of Pediatric Dentistry, Stomatological Hospital Southern Medical University Guangzhou China |
| Author_xml | – sequence: 1 givenname: Peixuan orcidid: 0000-0002-0085-2604 surname: Wang fullname: Wang, Peixuan organization: Southern Medical University – sequence: 2 givenname: Hong surname: Qian fullname: Qian, Hong email: sqianh@126.com organization: Southern Medical University – sequence: 3 givenname: Manxue surname: Xiao fullname: Xiao, Manxue organization: Southern Medical University – sequence: 4 givenname: Jingwen surname: Lv fullname: Lv, Jingwen organization: Southern Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36705417$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jff_2024_106112 crossref_primary_10_1007_s00210_024_03152_1 crossref_primary_10_3390_metabo14020122 crossref_primary_10_3390_nu15245082 crossref_primary_10_4240_wjgs_v16_i3_871 crossref_primary_10_3389_fcvm_2023_1126391 crossref_primary_10_3390_biomedicines11082107 crossref_primary_10_3390_ijms241713619 |
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Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence... Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown... Abstract Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects.... BackgroundInterleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence... Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced... Abstract Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects.... |
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| SubjectTerms | Apoptosis Arthritis Cells, Cultured Cytokines DNA methylation Endoplasmic reticulum Genes Interleukin-1beta interleukin‐1β Kinases MAPKs signaling pathway Mitochondria NF‐κB signaling pathway Oxidative stress Phosphatidylinositol 3-Kinases Phosphorylation PI3K/Akt signaling pathway Proteins Review Signal Transduction Tumor necrosis factor-TNF |
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| Title | Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects |
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