Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects
Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, var...
Saved in:
Published in | Immunity, Inflammation and Disease Vol. 11; no. 1; pp. e762 - n/a |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
John Wiley & Sons, Inc
01.01.2023
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background
Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease.
Methods
This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.
Results
IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis.
Conclusion
This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments.
Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes, focusing on the role of signaling pathways. This article also briefly describes the potential of signal pathway‐targeted therapy in the prevention and treatment of disease, using the application of signal pathways in the treatment of disc degeneration and osteoarthritis as examples. |
---|---|
AbstractList | Abstract
Background
Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease.
Methods
This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.
Results
IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐
k
B signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis.
Conclusion
This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes, focusing on the role of signaling pathways. This article also briefly describes the potential of signal pathway‐targeted therapy in the prevention and treatment of disease, using the application of signal pathways in the treatment of disc degeneration and osteoarthritis as examples. Abstract Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease. Methods This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. Results IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis. Conclusion This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease. This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. IL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis. This review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL‐1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL‐1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway‐targeted therapy in the prevention and treatment of disease. Methods This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL‐1β and apoptosis. The relevant studies using the keywords of “IL‐1β‐induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. Results IL‐1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF‐kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K‐Akt signaling pathway can inhibit apoptosis. Conclusion This review indicates that IL‐1β‐induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced apoptosis in pathological processes, focusing on the role of signaling pathways. This article also briefly describes the potential of signal pathway‐targeted therapy in the prevention and treatment of disease, using the application of signal pathways in the treatment of disc degeneration and osteoarthritis as examples. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease.BACKGROUNDInterleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease.This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.METHODSThis is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.IL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis.RESULTSIL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis.This review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments.CONCLUSIONThis review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. BackgroundInterleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease.MethodsThis is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of “IL-1β-induced apoptosis” and “signaling pathways” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed.ResultsIL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-kB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis.ConclusionThis review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments. |
Author | Xiao, Manxue Qian, Hong Lv, Jingwen Wang, Peixuan |
AuthorAffiliation | 1 Department of Pediatric Dentistry, Stomatological Hospital Southern Medical University Guangzhou China |
AuthorAffiliation_xml | – name: 1 Department of Pediatric Dentistry, Stomatological Hospital Southern Medical University Guangzhou China |
Author_xml | – sequence: 1 givenname: Peixuan orcidid: 0000-0002-0085-2604 surname: Wang fullname: Wang, Peixuan organization: Southern Medical University – sequence: 2 givenname: Hong surname: Qian fullname: Qian, Hong email: sqianh@126.com organization: Southern Medical University – sequence: 3 givenname: Manxue surname: Xiao fullname: Xiao, Manxue organization: Southern Medical University – sequence: 4 givenname: Jingwen surname: Lv fullname: Lv, Jingwen organization: Southern Medical University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36705417$$D View this record in MEDLINE/PubMed |
BookMark | eNp1ktFqFDEUhoNUbK0Fn0AC3ngz9SSZmcx4IZRadWFBEb0OZzNndrPMJuNkxrJ3PkKfxQfxIXwSs91aW0EISTj5-PjJOY_ZgQ-eGHsq4FQAyJfONepUl_IBO5JQQJYXUh_cuR-ykxjXACBAaQXVI3aoSg1FLvQRW38KHfHQ8uiWHjs-DuhjM9nRBc97HFeXuI3ceT6b__p-JX7-SLvzCaCGYx_6MUQXX_GPiQxdWDqbHOgbPq5owJ6m0VmOsSc7xifsYYtdpJOb85h9eXvx-fx9Nv_wbnZ-Ns9soaTM0FYKYVFTs5BY5ZVECXVLOVCrci2lFalmASqtrW4LCUC0ELqVqJRQtVXHbLb3NgHXph_cBoetCejMdSEMS4NDytWRUQKLtGxDlcxVVaJAalBqZZtK56CT6_Xe1U-LDTWWfPqg7p70_ot3K7MM30xdKV2rKgle3AiG8HWiOJqNi5a6Dj2FKRqpNQhRlzkk9Pk_6DpMQ2rKjirruijzUv4V2iHEOFB7G0aA2c2D2c2D0dfos7vhb8E_3U9AtgcuXUfb_4rMbPZG7YS_ATikwzw |
CitedBy_id | crossref_primary_10_1016_j_jff_2024_106112 crossref_primary_10_1007_s00210_024_03152_1 crossref_primary_10_3390_metabo14020122 crossref_primary_10_3390_nu15245082 crossref_primary_10_4240_wjgs_v16_i3_871 crossref_primary_10_3389_fcvm_2023_1126391 crossref_primary_10_3390_biomedicines11082107 crossref_primary_10_3390_ijms241713619 |
Cites_doi | 10.1007/s10753-017-0516-6 10.1016/j.bcp.2022.114932 10.3389/fphar.2018.00092 10.1002/cbin.11541 10.1016/j.immuni.2019.03.012 10.1002/jcb.29611 10.1126/scisignal.aao4170 10.3892/mmr.2021.12528 10.1096/fj.201802805RR 10.1016/j.jep.2022.115536 10.1080/21655979.2021.2017700 10.3389/fphys.2021.617654 10.1038/s41419-018-1121-9 10.2147/DDDT.S270345 10.14503/THIJ-14-4254 10.1002/jcp.30386 10.1080/03008207.2018.1442445 10.1016/j.biopha.2018.09.161 10.1155/2022/8999899 10.3390/ijms222413254 10.2106/00004623-200604000-00012 10.1002/jcp.30154 10.1007/s11010-008-9997-9 10.1155/2020/1535201 10.1042/BSR20190043 10.1007/s00395-019-0745-y 10.1007/s11255-017-1658-z 10.1053/jhep.2000.18291 10.1016/j.tox.2022.153132 10.1080/03008207.2022.2063121 10.1016/j.archger.2022.104748 10.1007/s11033-022-07467-1 10.1089/ars.2008.2400 10.1210/endocr/bqz028 10.1016/j.bbrc.2021.01.108 10.3389/fphar.2022.861183 10.1016/j.bbrc.2019.06.016 10.1021/acs.jafc.8b02656 10.1186/s13018-022-03202-5 10.3390/toxins13030187 10.1016/j.intimp.2020.107150 10.1016/j.neuropharm.2016.03.019 10.1016/j.intimp.2021.107857 10.1097/MD.0000000000022241 10.1002/jcp.20482 10.1158/0008-5472.CAN-05-4533 10.1016/j.freeradbiomed.2018.09.025 10.1159/000488632 10.1097/MED.0b013e32833bf6dc 10.1002/jcp.29175 10.1038/srep41067 10.1016/j.freeradbiomed.2008.09.021 10.1016/j.intimp.2022.109029 10.1016/j.jep.2021.114791 10.3390/ijms21249393 10.1016/j.freeradbiomed.2017.09.001 10.1016/j.biopha.2017.03.075 10.1155/2019/4695381 10.1038/s41598-022-16093-7 10.3390/molecules25092033 10.1016/j.freeradbiomed.2005.05.015 10.1016/j.intimp.2019.01.004 10.5009/gnl19312 10.1016/j.cyto.2022.155809 10.1016/j.molmet.2017.05.016 10.3390/ijms20215383 10.1038/s41420-021-00441-z 10.1186/1472-6890-6-5 10.3390/antiox10020186 10.1080/15592294.2019.1699893 10.21037/atm-22-3203 10.1016/j.joca.2021.11.003 10.1016/j.arr.2019.100978 10.1111/dom.12873 10.1074/jbc.M202862200 10.7717/peerj.1640 10.1016/j.intimp.2021.108048 10.1074/jbc.M107231200 10.3892/etm.2022.11267 10.1186/s13045-019-0744-3 10.1016/j.intimp.2022.108996 10.1080/15384101.2021.1911914 10.3892/etm.2021.10983 10.1016/j.jneuroim.2017.03.005 10.1007/s11626-016-0086-1 10.1038/cddis.2017.62 10.18632/oncotarget.16716 10.18632/aging.102194 |
ContentType | Journal Article |
Copyright | 2023 The Authors. published by John Wiley & Sons Ltd. 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2023 The Authors. published by John Wiley & Sons Ltd. – notice: 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. – notice: 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
DOI | 10.1002/iid3.762 |
DatabaseName | Wiley Online Library Open Access Wiley Online Library Free Content Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: 7X7 name: Health & Medical Collection url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
DocumentTitleAlternate | WANG et al |
EISSN | 2050-4527 |
EndPage | n/a |
ExternalDocumentID | oai_doaj_org_article_31a51a5cde824386a1aeda273cd87407 10_1002_iid3_762 36705417 IID3762 |
Genre | reviewArticle Journal Article Review |
GroupedDBID | 0R~ 1OC 24P 53G 5VS 7X7 8-1 8FI 8FJ AAHHS AAZKR ABDBF ABUWG ACCFJ ACXQS ADBBV ADKYN ADRAZ ADZMN ADZOD AEEZP AEQDE AFKRA AIWBW AJBDE ALAGY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU DIK EBS EJD ESX FYUFA GODZA GROUPED_DOAJ HMCUK HYE IAO IHR INH KQ8 M48 M~E O9- OK1 OVD PIMPY PQQKQ PROAC RPM TEORI UKHRP WIN CGR CUY CVF ECM EIF ITC NPM AAYXX CITATION 3V. 7XB 8FK AZQEC DWQXO K9. PQEST PQUKI PRINS 7X8 5PM |
ID | FETCH-LOGICAL-c5322-ac83a0b9edb2a8482a209fe40ef34722c1482c00877c7f5200eeb17f2a33139c3 |
IEDL.DBID | RPM |
ISSN | 2050-4527 |
IngestDate | Tue Oct 22 15:12:45 EDT 2024 Tue Sep 17 21:30:24 EDT 2024 Tue Sep 10 16:30:35 EDT 2024 Thu Oct 10 18:23:53 EDT 2024 Thu Sep 26 16:52:12 EDT 2024 Wed Oct 23 09:59:32 EDT 2024 Sat Aug 24 00:56:50 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | MAPKs signaling pathway apoptosis PI3K/Akt signaling pathway NF-κB signaling pathway interleukin-1β |
Language | English |
License | Attribution 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c5322-ac83a0b9edb2a8482a209fe40ef34722c1482c00877c7f5200eeb17f2a33139c3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
ORCID | 0000-0002-0085-2604 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837938/ |
PMID | 36705417 |
PQID | 2769956462 |
PQPubID | 2034588 |
PageCount | 9 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_31a51a5cde824386a1aeda273cd87407 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9837938 proquest_miscellaneous_2770119640 proquest_journals_2769956462 crossref_primary_10_1002_iid3_762 pubmed_primary_36705417 wiley_primary_10_1002_iid3_762_IID3762 |
PublicationCentury | 2000 |
PublicationDate | January 2023 |
PublicationDateYYYYMMDD | 2023-01-01 |
PublicationDate_xml | – month: 01 year: 2023 text: January 2023 |
PublicationDecade | 2020 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: Bognor Regis – name: Hoboken |
PublicationTitle | Immunity, Inflammation and Disease |
PublicationTitleAlternate | Immun Inflamm Dis |
PublicationYear | 2023 |
Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
References | 2017; 40 2021; 25 2017; 6 2017; 7 2017; 8 2009; 46 2022; 297 2019; 2019 2021; 20 2021; 23 2019; 50 2021; 22 2017; 47 2019; 11 2010; 17 2020; 121 2016; 107 2017; 49 2019; 12 2020; 161 2002; 277 2022; 23 2020; 15 2019; 19 2020; 14 2018; 41 2020; 57 2022; 63 2020; 99 2017; 112 2018; 46 2009; 11 2018; 9 2022; 284 2019; 20 2021; 236 2006; 66 2015; 42 2019; 23 2019; 69 2019; 114 2022; 30 2019; 516 2018; 33 2006; 206 2005; 39 2009; 324 2021; 7 2022; 197 2022; 110 2022; 151 2021; 45 2019; 33 2021; 546 2019; 39 2019; 104 2006; 6 2019; 109 2018; 66 2022; 49 2021; 90 2016; 4 2017; 307 2021; 13 2018; 18 2017; 53 2018; 17 2021; 10 2021; 98 2017; 90 2022; 2022 2020; 2020 2021; 12 2021; 99 2006; 88 2019; 43 2000; 32 2022; 12 2022; 13 2020; 25 2017; 19 2020; 24 2020; 235 2022; 10 2020; 21 2018; 11 2022; 469 2018; 59 2022; 17 2022; 102 2019; 132 e_1_2_6_53_1 Guo JT (e_1_2_6_32_1) 2019; 23 e_1_2_6_30_1 FU HY (e_1_2_6_61_1) 2020; 24 e_1_2_6_72_1 e_1_2_6_91_1 e_1_2_6_19_1 Xu Z (e_1_2_6_90_1) 2022; 2022 e_1_2_6_11_1 e_1_2_6_34_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_57_1 e_1_2_6_99_1 e_1_2_6_64_1 e_1_2_6_87_1 e_1_2_6_60_1 e_1_2_6_83_1 e_1_2_6_102_1 e_1_2_6_9_1 Zhang Q (e_1_2_6_73_1) 2018; 41 e_1_2_6_5_1 Ji B (e_1_2_6_37_1) 2017; 40 Ling GQ (e_1_2_6_77_1) 2019; 19 e_1_2_6_49_1 e_1_2_6_22_1 e_1_2_6_45_1 e_1_2_6_26_1 e_1_2_6_68_1 e_1_2_6_54_1 e_1_2_6_96_1 e_1_2_6_31_1 e_1_2_6_50_1 e_1_2_6_92_1 Cai L (e_1_2_6_58_1) 2017; 47 Guo HT (e_1_2_6_88_1) 2019; 20 e_1_2_6_35_1 e_1_2_6_12_1 Sun FF (e_1_2_6_95_1) 2019; 2019 e_1_2_6_39_1 e_1_2_6_16_1 e_1_2_6_84_1 e_1_2_6_42_1 e_1_2_6_65_1 e_1_2_6_80_1 Lu L (e_1_2_6_41_1) 2019; 43 e_1_2_6_101_1 Qian H (e_1_2_6_17_1) 2018; 18 e_1_2_6_6_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_27_1 e_1_2_6_69_1 e_1_2_6_51_1 e_1_2_6_74_1 e_1_2_6_97_1 e_1_2_6_70_1 e_1_2_6_93_1 Rao Z (e_1_2_6_40_1) 2018; 17 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_59_1 e_1_2_6_55_1 e_1_2_6_62_1 e_1_2_6_85_1 e_1_2_6_43_1 e_1_2_6_81_1 e_1_2_6_20_1 e_1_2_6_100_1 Ezquerro S (e_1_2_6_46_1) 2019; 104 e_1_2_6_7_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_66_1 e_1_2_6_89_1 e_1_2_6_28_1 e_1_2_6_47_1 e_1_2_6_52_1 e_1_2_6_98_1 e_1_2_6_75_1 e_1_2_6_10_1 e_1_2_6_94_1 e_1_2_6_71_1 e_1_2_6_14_1 e_1_2_6_33_1 Lu L (e_1_2_6_76_1) 2020; 2020 e_1_2_6_18_1 e_1_2_6_56_1 e_1_2_6_79_1 e_1_2_6_63_1 e_1_2_6_86_1 e_1_2_6_21_1 e_1_2_6_82_1 Song H (e_1_2_6_78_1) 2018; 33 e_1_2_6_8_1 e_1_2_6_4_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_29_1 e_1_2_6_44_1 e_1_2_6_67_1 |
References_xml | – volume: 42 start-page: 109 issue: 2 year: 2015 end-page: 116 article-title: Pathways involved in interleukin‐1β‐mediated murine cardiomyocyte apoptosis publication-title: Tex Heart Inst J – volume: 206 start-page: 468 issue: 2 year: 2006 end-page: 476 article-title: Enhancement of apoptosis by nitric oxide released from α‐phenyl‐tert‐butyl nitrone under hyperthermic conditions publication-title: J Cell Physiol – volume: 102 year: 2022 article-title: Omentin‐1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells publication-title: Arch Gerontol Geriat – volume: 57 year: 2020 article-title: Intervertebral disc ageing and degeneration: the antiapoptotic effect of oestrogen publication-title: Ageing Res Rev – volume: 41 start-page: 2270 year: 2018 end-page: 2278 article-title: CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling publication-title: Int J Mol Med – volume: 14 start-page: 735 issue: 6 year: 2020 end-page: 745 article-title: eradication induced constant decrease in interleukin‐1B expression over more than 5 years in patients with gastric cancer and dysplasia publication-title: Gut Liver – volume: 2022 start-page: 1 year: 2022 end-page: 7 article-title: The protective effect of ginsenoside Rg1 on apoptosis in human ankle joint traumatic arthritis chondrocytes publication-title: Evid Based Complement Alter Med – volume: 59 start-page: 593 issue: 6 year: 2018 end-page: 600 article-title: Interleukin‐1β induces apoptosis in annulus fibrosus cells through the extracellular signal‐regulated kinase pathway publication-title: Connect Tissue Res – volume: 4 year: 2016 article-title: Combined effect of 17β‐estradiol and resveratrol against apoptosis induced by interleukin‐1β in rat nucleus pulposus cells via PI3K/Akt/caspase‐3 pathway publication-title: PeerJ – volume: 10 start-page: 186 issue: 2 year: 2021 article-title: Redox homeostasis in poultry: regulatory roles of NF‐κB publication-title: Antioxidants – volume: 43 start-page: 1679 issue: 4 year: 2019 end-page: 1686 article-title: Berberine prevents human nucleus pulposus cells from IL‑1β‑induced extracellular matrix degradation and apoptosis by inhibiting the NF‑κB pathway publication-title: Int J Mol Med – volume: 53 start-page: 124 issue: 2 year: 2017 end-page: 131 article-title: Proliferation of rabbit chondrocyte and inhibition of IL‐1β‐induced apoptosis through MEK/ERK signaling by statins publication-title: In Vitro Cell Dev Biol Anim – volume: 161 issue: 2 year: 2020 article-title: The endoplasmic reticulum and calcium homeostasis in pancreatic beta cells publication-title: Endocrinology – volume: 8 issue: 3 year: 2017 article-title: Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK‐dependent hepatocyte apoptosis publication-title: Cell Death Dis – volume: 40 start-page: 725 issue: 3 year: 2017 end-page: 734 article-title: Simvastatin inhibits IL‐1β‐induced apoptosis and extracellular matrix degradation by suppressing the NF‐kB and MAPK pathways in nucleus pulposus cells publication-title: Inflammation – volume: 21 start-page: 9393 issue: 24 year: 2020 article-title: The role of nitric oxide in cancer: master regulator or not? publication-title: Int J Mol Sci – volume: 30 start-page: 315 issue: 2 year: 2022 end-page: 328 article-title: ERK1/2‐mediated activation of DRP1 regulates mitochondrial dynamics and apoptosis in chondrocytes publication-title: Osteoarth Cartil – volume: 22 issue: 24 year: 2021 article-title: Constitutive, basal, and β‐alanine‐mediated activation of the human mas‐related G protein‐coupled receptor D induces release of the inflammatory cytokine IL‐6 and is dependent on NF‐κB signaling publication-title: Int J Mol Sci – volume: 9 start-page: 92 year: 2018 article-title: Scutellarin increases cisplatin‐induced apoptosis and autophagy to overcome cisplatin resistance in non‐small cell lung cancer via ERK/p53 and c‐met/AKT signaling pathways publication-title: Front Pharmacol – volume: 98 year: 2021 article-title: Circ_0008956 contributes to IL‐1β‐induced osteoarthritis progression via miR‐149‐5p/NAMPT axis publication-title: Int Immunopharmacol – volume: 88 start-page: 771 issue: 4 year: 2006 end-page: 779 article-title: Anti‐apoptotic effects of caspase inhibitors on rat intervertebral disc cells publication-title: J Bone Joint Surg – volume: 12 issue: 1 year: 2022 article-title: Glutamine exerts a protective effect on osteoarthritis development by inhibiting the Jun N‐terminal kinase and nuclear factor Kappa‐b signaling pathways publication-title: Sci Rep – volume: 107 start-page: 68 year: 2016 end-page: 78 article-title: Fluoxetine protects against IL‐1β‐induced neuronal apoptosis via downregulation of p53 publication-title: Neuropharmacology – volume: 277 start-page: 33501 issue: 36 year: 2002 end-page: 33508 article-title: p38 kinase regulates nitric oxide‐induced apoptosis of articular chondrocytes by accumulating p53 via NFκB‐dependent transcription and stabilization by serine 15 phosphorylation publication-title: J Biol Chem – volume: 9 start-page: 1088 issue: 11 year: 2018 article-title: Progressive waves of IL‐1β release by primary human monocytes via sequential activation of vesicular and gasdermin D‐mediated secretory pathways publication-title: Cell Death Dis – volume: 114 start-page: 38 issue: 5 year: 2019 article-title: Mitochondrial bioenergetics links inflammation and cardiac contractility in endotoxemia publication-title: Basic Res Cardiol – volume: 17 start-page: 3418 issue: 2 year: 2018 end-page: 3424 article-title: Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis publication-title: Mol Med Rep – volume: 297 year: 2022 article-title: Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF‐κB pathways publication-title: J Ethnopharmacol – volume: 39 issue: 3 year: 2019 article-title: Resveratrol inhibits IL‐1β‐mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway publication-title: Biosci Rep – volume: 13 year: 2022 article-title: An inducible nitric oxide synthase dimerization inhibitor prevents the progression of osteoarthritis publication-title: Front Pharmacol – volume: 24 start-page: 8694 year: 2020 end-page: 8702 article-title: SF1670 inhibits apoptosis and inflammation via the PTEN/Akt pathway and thus protects intervertebral disc degeneration publication-title: Eur Rev Med Pharmacol Sci – volume: 469 year: 2022 article-title: NaF‐induced neurotoxicity via activation of the IL‐1β/JNK signaling pathway publication-title: Toxicology – volume: 90 start-page: 414 year: 2017 end-page: 420 article-title: Peroxiredoxin 4 inhibits IL‐1β‐induced chondrocyte apoptosis via PI3K/AKT signaling publication-title: Biomed Pharmacother – volume: 7 issue: 1 year: 2017 article-title: IL‐1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells publication-title: Sci Rep – volume: 7 start-page: 56 issue: 1 year: 2021 article-title: Islet neogenesis associated protein (INGAP) protects pancreatic β cells from IL‐1β and IFNγ‐induced apoptosis publication-title: Cell Death Discov – volume: 10 start-page: 748 issue: 13 year: 2022 article-title: Panax notoginseng saponin reduces IL‐1β‐stimulated apoptosis and endoplasmic reticulum stress of nucleus pulposus cells by suppressing miR‐222‐3p publication-title: Ann Transl Med – volume: 12 year: 2021 article-title: LncRNA MEG3 protects chondrocytes from IL‐1β‐induced inflammation via regulating miR‐9‐5p/KLF4 axis publication-title: Front Physiol – volume: 11 start-page: 2057 issue: 9 year: 2009 end-page: 2064 article-title: Hypoxia activates NF‐κB–dependent gene expression through the canonical signaling pathway publication-title: Antioxid Redox Signaling – volume: 99 issue: 38 year: 2020 article-title: Quercetin inhibits TNF‐α induced HUVECs apoptosis and inflammation via downregulating NF‐kB and AP‐1 signaling pathway in vitro publication-title: Medicine – volume: 14 start-page: 4251 year: 2020 end-page: 4261 article-title: EGCG upregulates UCP3 levels to protect MIN6 pancreatic islet cells from interleukin‐1β‐induced apoptosis publication-title: DDDT – volume: 516 start-page: 209 issue: 1 year: 2019 end-page: 214 article-title: FAM3A protects chondrocytes against interleukin‐1β‐induced apoptosis through regulating PI3K/Akt/mTOR pathway publication-title: Biochem Biophys Res Commun – volume: 11 start-page: 6371 issue: 16 year: 2019 end-page: 6384 article-title: MiR‐27a promotes the autophagy and apoptosis of IL‐1β treated‐articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling publication-title: Aging – volume: 112 start-page: 567 year: 2017 end-page: 577 article-title: The caspase‐8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production publication-title: Free Radic Biol Med – volume: 121 start-page: 4204 issue: 10 year: 2020 end-page: 4213 article-title: Ablation of PKM2 ameliorated ER stress‐induced apoptosis and associated inflammation response in IL‐1β‐treated chondrocytes via blocking Rspo2‐mediated Wnt/β‐catenin signaling publication-title: J Cell Biochem – volume: 66 start-page: 6353 issue: 12 year: 2006 end-page: 6360 article-title: Nitric oxide regulates cell sensitivity to cisplatin‐induced apoptosis through S‐nitrosylation and inhibition of Bcl‐2 ubiquitination publication-title: Cancer Res – volume: 284 year: 2022 article-title: Anti‐proliferation and anti‐inflammation effects of corilagin in rheumatoid arthritis by downregulating NF‐κB and MAPK signaling pathways publication-title: J Ethnopharmacol – volume: 90 year: 2021 article-title: LncRNA SNHG7 alleviates IL‐1β‐induced osteoarthritis by inhibiting miR‐214‐5p‐mediated PPARGC1B signaling pathways publication-title: Int Immunopharmacol – volume: 6 start-page: 5 year: 2006 article-title: Trauma induces apoptosis in human thoracolumbar intervertebral discs publication-title: BMC Clin Pathol – volume: 8 start-page: 41988 issue: 26 year: 2017 end-page: 42000 article-title: Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway publication-title: Oncotarget – volume: 20 start-page: 1523 issue: 2 year: 2019 end-page: 1530 article-title: 17β‑Estradiol protects against interleukin‑1β‑induced apoptosis in rat nucleus pulposus cells via the mTOR/caspase‑3 pathway publication-title: Mol Med Rep – volume: 39 start-page: 890 issue: 7 year: 2005 end-page: 899 article-title: Nitric oxide induces apoptosis via AP‐1‐driven upregulation of COX‐2 in rat pheochromocytoma cells publication-title: Free Radic Biol Med – volume: 277 start-page: 1332 issue: 2 year: 2002 end-page: 1339 article-title: ERK‐1/2 and p38 kinase oppositely regulate nitric oxide‐induced apoptosis of chondrocytes in association with p53, caspase‐3, and differentiation status publication-title: J Biol Chem – volume: 46 start-page: 62 issue: 1 year: 2009 end-page: 69 article-title: Sustained oxidative stress inhibits NF‐κB activation partially via inactivating the proteasome publication-title: Free Radic Biol Med – volume: 45 start-page: 976 issue: 5 year: 2021 end-page: 988 article-title: Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes publication-title: Cell Biol Int – volume: 49 start-page: 6459 issue: 7 year: 2022 end-page: 6466 article-title: Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway publication-title: Mol Biol Rep – volume: 2022 start-page: 1 year: 2022 end-page: 15 article-title: Smad7 is highly expressed in human degenerative discs and participates in IL‐1β‐induced apoptosis of rat AF cells via the mitochondria pathway publication-title: Oxid Med Cell Longevity – volume: 2019 start-page: 1 year: 2019 end-page: 10 article-title: Tricetin protects rat chondrocytes against IL‐1β‐Induced inflammation and apoptosis publication-title: Oxid Med Cell Longevity – volume: 23 start-page: 337 issue: 5 year: 2022 article-title: Ketorolac tromethamine alleviates IL‐1β‐induced chondrocyte injury by inhibiting COX‐2 expression publication-title: Exp Ther Med – volume: 236 start-page: 4369 issue: 6 year: 2021 end-page: 4386 article-title: Hydrogen sulfide protects against IL‐1β‐induced inflammation and mitochondrial dysfunction‐related apoptosis in chondrocytes and ameliorates osteoarthritis publication-title: J Cell Physiol – volume: 20 start-page: 5383 issue: 21 year: 2019 article-title: Anti‐inflammatory and anti‐apoptotic effects of stybenpropol A on human umbilical vein endothelial cells publication-title: Int J Mol Sci – volume: 33 start-page: 12515 issue: 11 year: 2019 end-page: 12527 article-title: Activation of ROS/MAPKs/NF‐κB/NLRP3 and inhibition of efferocytosis in osteoclast‐mediated diabetic osteoporosis publication-title: FASEB J – volume: 18 start-page: 1067 year: 2018 end-page: 1073 article-title: Caspase‑9 was involved in cell apoptosis in human dental pulp stem cells from deciduous teeth publication-title: Mol Med Rep – volume: 17 start-page: 304 issue: 1 year: 2022 article-title: Long non‐coding RNA Gm37494 alleviates osteoarthritis chondrocyte injury via the microRNA‐181a‐5p/GABRA1 axis publication-title: J Orthop Surg – volume: 324 start-page: 183 issue: 1‐2 year: 2009 end-page: 190 article-title: IL‐1β caused pancreatic β‐cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca release through the c‐Jun N‐terminal kinase pathway publication-title: Mol Cell Biochem – volume: 11 issue: 524 year: 2018 article-title: Mutant and wild‐type p53 form complexes with p73 upon phosphorylation by the kinase JNK publication-title: Sci Signal – volume: 13 start-page: 187 issue: 3 year: 2021 article-title: Zearalenone induces endothelial cell apoptosis through activation of a cytosolic Ca2+/ERK1/2/p53/Caspase 3 signaling pathway publication-title: Toxins – volume: 66 start-page: 9960 issue: 38 year: 2018 end-page: 9967 article-title: Reactive oxygen species and p53 mediated activation of p38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells publication-title: J Agricult Food Chem – volume: 25 start-page: 12 issue: 1 year: 2021 article-title: Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes publication-title: Mol Med Rep – volume: 110 year: 2022 article-title: Depletion of circ_0128846 ameliorates interleukin‐1β‐induced human chondrocyte apoptosis and inflammation through the miR‐940/PTPN12 pathway publication-title: Int Immunopharmacol – volume: 2020 start-page: 1 year: 2020 end-page: 14 article-title: Melatonin ameliorates MI‐induced cardiac remodeling and apoptosis through a JNK/p53‐dependent mechanism in diabetes mellitus publication-title: Oxid Med Cell Longevity – volume: 25 start-page: 2033 issue: 9 year: 2020 article-title: Anti‐osteoarthritic effects of an herbal composition LI73014F2 on Interleukin‐1β‐induced primary human articular chondrocytes publication-title: Molecules – volume: 33 start-page: 73 issue: 1 year: 2018 end-page: 79 article-title: Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals publication-title: Histol. Histopathol – volume: 132 start-page: 90 year: 2019 end-page: 100 article-title: Redox and NF‐κB signaling in osteoarthritis publication-title: Free Radic Biol Med – volume: 6 start-page: 833 issue: 8 year: 2017 end-page: 844 article-title: Amyloid formation disrupts the balance between interleukin‐1β and interleukin‐1 receptor antagonist in human islets publication-title: Mol Metab – volume: 40 start-page: 1709 year: 2017 end-page: 1718 article-title: Isoliquiritigenin suppresses IL‐1β induced apoptosis and inflammation in chondrocyte‐like ATDC5 cells by inhibiting NF‐κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection publication-title: Int J Mol Med – volume: 13 start-page: 1399 issue: 1 year: 2022 end-page: 1410 article-title: The protective effects of dezocine on interleukin‐1β‐induced inflammation, oxidative stress and apoptosis of human nucleus pulposus cells and the possible mechanisms publication-title: Bioengineered – volume: 15 start-page: 511 issue: 5 year: 2020 end-page: 523 article-title: Stromal‐associated cytokines bias the interplay between gene expression and DNA methylation in human breast cancers publication-title: Epigenetics – volume: 151 year: 2022 article-title: Aconiti lateralis radix praeparata lipid‐soluble alkaloids alleviates IL‐1β‐induced inflammation of human fibroblast‐like synoviocytes in rheumatoid arthritis by inhibiting NF‐κB and MAPKs signaling pathways and inducing apoptosis publication-title: Cytokine – volume: 197 year: 2022 article-title: Inhibition of IRE1 suppresses the catabolic effect of IL‐1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo publication-title: Biochem Pharmacol – volume: 19 start-page: 327 issue: 1 year: 2019 end-page: 337 article-title: C‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats publication-title: Mol Med Rep – volume: 50 start-page: 778 issue: 4 year: 2019 end-page: 795 article-title: Interleukin‐1 and related cytokines in the regulation of inflammation and immunity publication-title: Immunity – volume: 63 start-page: 650 year: 2022 end-page: 662 article-title: Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration publication-title: Connect Tissue Res – volume: 104 start-page: 21 issue: 1 year: 2019 end-page: 37 article-title: Ghrelin reduces TNF‐α‐induced human hepatocyte apoptosis, autophagy, and pyroptosis: role in obesity‐associated NAFLD publication-title: J Clin Endocrinol Metab – volume: 20 start-page: 960 issue: 10 year: 2021 end-page: 977 article-title: Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL‑1β‑induced extracellular matrix degradation publication-title: Cell Cycle – volume: 12 start-page: 60 issue: 1 year: 2019 article-title: Ilamycin C induces apoptosis and inhibits migration and invasion in triple‐negative breast cancer by suppressing IL‐6/STAT3 pathway publication-title: J Hematol Oncol – volume: 110 year: 2022 article-title: The miR‐548d‐5p/SP1 signaling axis regulates chondrocyte proliferation and inflammatory responses in osteoarthritis publication-title: Int Immunopharmacol – volume: 99 year: 2021 article-title: TRIM38 protects chondrocytes from IL‐1β‐induced apoptosis and degeneration via negatively modulating nuclear factor (NF)‐κB signaling publication-title: Int Immunopharmacol – volume: 17 start-page: 314 issue: 4 year: 2010 end-page: 321 article-title: Role of IL‐1β in type 2 diabetes publication-title: Curr Opin Endocrinol Diab Obes – volume: 32 start-page: 770 issue: 4 Pt 1 year: 2000 end-page: 778 article-title: Nitric oxide prevents tumor necrosis factor α–induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S‐nitrosylation of caspase‐8 publication-title: Hepatology – volume: 23 start-page: 10211 issue: 23 year: 2019 end-page: 10217 article-title: Effect of IL‐1β on apoptosis of synovial cells in rheumatoid arthritis rats via the NF‐κB pathway publication-title: Eur Rev Med Pharmacol Sci – volume: 23 start-page: 61 issue: 1 year: 2021 article-title: LIM mineralization protein‐1 inhibits IL‐1β‐induced human chondrocytes injury by altering the NF‐κB and MAPK/JNK pathways publication-title: Exp Ther Med – volume: 109 start-page: 1586 year: 2019 end-page: 1592 article-title: Luteolin inhibits IL‐1β‐induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model publication-title: Biomed Pharmacother – volume: 236 start-page: 7504 issue: 11 year: 2021 end-page: 7515 article-title: Moderate mechanical stress suppresses the IL‐1β‐induced chondrocyte apoptosis by regulating mitochondrial dynamics publication-title: J Cell Physiol – volume: 19 start-page: 682 issue: 5 year: 2017 end-page: 694 article-title: Dual role of interleukin‐1β in islet amyloid formation and its β‐cell toxicity: implications for type 2 diabetes and islet transplantation publication-title: Diabetes, Obes Metab – volume: 307 start-page: 7 year: 2017 end-page: 13 article-title: N‐methyl‐d‐aspartate receptor‐mediated calcium overload and endoplasmic reticulum stress are involved in interleukin‐1beta‐induced neuronal apoptosis in rat hippocampus publication-title: J Neuroimmunol – volume: 46 start-page: 644 issue: 2 year: 2018 end-page: 653 article-title: Hemeoxygenase‐1 suppresses IL‐1β‐induced apoptosis through the NF‐κB pathway in human degenerative nucleus pulposus cells publication-title: Cell Physiol Biochem – volume: 69 start-page: 398 year: 2019 end-page: 407 article-title: Ligustilide alleviated IL‐1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo publication-title: Int Immunopharmacol – volume: 235 start-page: 2710 issue: 3 year: 2020 end-page: 2721 article-title: microRNA‐132 inhibits cardiomyocyte apoptosis and myocardial remodeling in myocardial infarction by targeting IL‐1β publication-title: J Cell Physiol – volume: 47 start-page: 563 issue: 5 year: 2017 end-page: 571 article-title: Aquaporin‐4 blockage by siRNA protects rat articular chondrocytes from IL‐1β‐induced apoptosis by inhibiting p38 MAPK signal pathway publication-title: Ann Clin Lab Sci – volume: 49 start-page: 1875 issue: 10 year: 2017 end-page: 1892 article-title: Heat shock protein 70/nitric oxide effect on stretched tubular epithelial cells linked to WT‐1 cytoprotection during neonatal obstructive nephropathy publication-title: Int Urol Nephrol – volume: 546 start-page: 46 year: 2021 end-page: 53 article-title: Interleukin‐1β induces pericyte apoptosis via the NF‐κB pathway in diabetic retinopathy publication-title: Biochem Biophys Res Commun – ident: e_1_2_6_42_1 doi: 10.1007/s10753-017-0516-6 – ident: e_1_2_6_54_1 doi: 10.1016/j.bcp.2022.114932 – ident: e_1_2_6_83_1 doi: 10.3389/fphar.2018.00092 – ident: e_1_2_6_39_1 doi: 10.1002/cbin.11541 – ident: e_1_2_6_2_1 doi: 10.1016/j.immuni.2019.03.012 – ident: e_1_2_6_24_1 doi: 10.1002/jcb.29611 – ident: e_1_2_6_79_1 doi: 10.1126/scisignal.aao4170 – ident: e_1_2_6_96_1 doi: 10.3892/mmr.2021.12528 – ident: e_1_2_6_50_1 doi: 10.1096/fj.201802805RR – ident: e_1_2_6_87_1 doi: 10.1016/j.jep.2022.115536 – ident: e_1_2_6_48_1 doi: 10.1080/21655979.2021.2017700 – ident: e_1_2_6_100_1 doi: 10.3389/fphys.2021.617654 – ident: e_1_2_6_12_1 doi: 10.1038/s41419-018-1121-9 – ident: e_1_2_6_49_1 doi: 10.2147/DDDT.S270345 – ident: e_1_2_6_29_1 doi: 10.14503/THIJ-14-4254 – ident: e_1_2_6_20_1 doi: 10.1002/jcp.30386 – ident: e_1_2_6_10_1 doi: 10.1080/03008207.2018.1442445 – ident: e_1_2_6_59_1 doi: 10.1016/j.biopha.2018.09.161 – ident: e_1_2_6_14_1 doi: 10.1155/2022/8999899 – ident: e_1_2_6_43_1 doi: 10.3390/ijms222413254 – ident: e_1_2_6_27_1 doi: 10.2106/00004623-200604000-00012 – ident: e_1_2_6_19_1 doi: 10.1002/jcp.30154 – ident: e_1_2_6_75_1 doi: 10.1007/s11010-008-9997-9 – volume: 2020 start-page: 1 year: 2020 ident: e_1_2_6_76_1 article-title: Melatonin ameliorates MI‐induced cardiac remodeling and apoptosis through a JNK/p53‐dependent mechanism in diabetes mellitus publication-title: Oxid Med Cell Longevity doi: 10.1155/2020/1535201 contributor: fullname: Lu L – volume: 2022 start-page: 1 year: 2022 ident: e_1_2_6_90_1 article-title: The protective effect of ginsenoside Rg1 on apoptosis in human ankle joint traumatic arthritis chondrocytes publication-title: Evid Based Complement Alter Med contributor: fullname: Xu Z – ident: e_1_2_6_15_1 doi: 10.1042/BSR20190043 – ident: e_1_2_6_18_1 doi: 10.1007/s00395-019-0745-y – ident: e_1_2_6_67_1 doi: 10.1007/s11255-017-1658-z – ident: e_1_2_6_69_1 doi: 10.1053/jhep.2000.18291 – ident: e_1_2_6_74_1 doi: 10.1016/j.tox.2022.153132 – ident: e_1_2_6_93_1 doi: 10.1080/03008207.2022.2063121 – ident: e_1_2_6_94_1 doi: 10.1016/j.archger.2022.104748 – ident: e_1_2_6_86_1 doi: 10.1007/s11033-022-07467-1 – volume: 33 start-page: 73 issue: 1 year: 2018 ident: e_1_2_6_78_1 article-title: Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals publication-title: Histol. Histopathol contributor: fullname: Song H – volume: 17 start-page: 3418 issue: 2 year: 2018 ident: e_1_2_6_40_1 article-title: Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis publication-title: Mol Med Rep contributor: fullname: Rao Z – ident: e_1_2_6_35_1 doi: 10.1089/ars.2008.2400 – ident: e_1_2_6_25_1 doi: 10.1210/endocr/bqz028 – ident: e_1_2_6_33_1 doi: 10.1016/j.bbrc.2021.01.108 – volume: 24 start-page: 8694 year: 2020 ident: e_1_2_6_61_1 article-title: SF1670 inhibits apoptosis and inflammation via the PTEN/Akt pathway and thus protects intervertebral disc degeneration publication-title: Eur Rev Med Pharmacol Sci contributor: fullname: FU HY – ident: e_1_2_6_53_1 doi: 10.3389/fphar.2022.861183 – ident: e_1_2_6_89_1 doi: 10.1016/j.bbrc.2019.06.016 – ident: e_1_2_6_62_1 doi: 10.1021/acs.jafc.8b02656 – ident: e_1_2_6_102_1 doi: 10.1186/s13018-022-03202-5 – ident: e_1_2_6_84_1 doi: 10.3390/toxins13030187 – ident: e_1_2_6_101_1 doi: 10.1016/j.intimp.2020.107150 – volume: 47 start-page: 563 issue: 5 year: 2017 ident: e_1_2_6_58_1 article-title: Aquaporin‐4 blockage by siRNA protects rat articular chondrocytes from IL‐1β‐induced apoptosis by inhibiting p38 MAPK signal pathway publication-title: Ann Clin Lab Sci contributor: fullname: Cai L – ident: e_1_2_6_63_1 doi: 10.1016/j.neuropharm.2016.03.019 – volume: 41 start-page: 2270 year: 2018 ident: e_1_2_6_73_1 article-title: CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling publication-title: Int J Mol Med contributor: fullname: Zhang Q – ident: e_1_2_6_99_1 doi: 10.1016/j.intimp.2021.107857 – ident: e_1_2_6_44_1 doi: 10.1097/MD.0000000000022241 – volume: 20 start-page: 1523 issue: 2 year: 2019 ident: e_1_2_6_88_1 article-title: 17β‑Estradiol protects against interleukin‑1β‑induced apoptosis in rat nucleus pulposus cells via the mTOR/caspase‑3 pathway publication-title: Mol Med Rep contributor: fullname: Guo HT – ident: e_1_2_6_65_1 doi: 10.1002/jcp.20482 – ident: e_1_2_6_68_1 doi: 10.1158/0008-5472.CAN-05-4533 – volume: 104 start-page: 21 issue: 1 year: 2019 ident: e_1_2_6_46_1 article-title: Ghrelin reduces TNF‐α‐induced human hepatocyte apoptosis, autophagy, and pyroptosis: role in obesity‐associated NAFLD publication-title: J Clin Endocrinol Metab contributor: fullname: Ezquerro S – volume: 18 start-page: 1067 year: 2018 ident: e_1_2_6_17_1 article-title: Caspase‑9 was involved in cell apoptosis in human dental pulp stem cells from deciduous teeth publication-title: Mol Med Rep contributor: fullname: Qian H – ident: e_1_2_6_34_1 doi: 10.1016/j.freeradbiomed.2018.09.025 – ident: e_1_2_6_31_1 doi: 10.1159/000488632 – ident: e_1_2_6_11_1 doi: 10.1097/MED.0b013e32833bf6dc – ident: e_1_2_6_6_1 doi: 10.1002/jcp.29175 – ident: e_1_2_6_16_1 doi: 10.1038/srep41067 – ident: e_1_2_6_56_1 doi: 10.1016/j.freeradbiomed.2008.09.021 – ident: e_1_2_6_97_1 doi: 10.1016/j.intimp.2022.109029 – volume: 43 start-page: 1679 issue: 4 year: 2019 ident: e_1_2_6_41_1 article-title: Berberine prevents human nucleus pulposus cells from IL‑1β‑induced extracellular matrix degradation and apoptosis by inhibiting the NF‑κB pathway publication-title: Int J Mol Med contributor: fullname: Lu L – ident: e_1_2_6_57_1 doi: 10.1016/j.jep.2021.114791 – ident: e_1_2_6_70_1 doi: 10.3390/ijms21249393 – ident: e_1_2_6_22_1 doi: 10.1016/j.freeradbiomed.2017.09.001 – ident: e_1_2_6_52_1 doi: 10.1016/j.biopha.2017.03.075 – volume: 2019 start-page: 1 year: 2019 ident: e_1_2_6_95_1 article-title: Tricetin protects rat chondrocytes against IL‐1β‐Induced inflammation and apoptosis publication-title: Oxid Med Cell Longevity doi: 10.1155/2019/4695381 contributor: fullname: Sun FF – ident: e_1_2_6_71_1 doi: 10.1038/s41598-022-16093-7 – ident: e_1_2_6_60_1 doi: 10.3390/molecules25092033 – ident: e_1_2_6_66_1 doi: 10.1016/j.freeradbiomed.2005.05.015 – ident: e_1_2_6_7_1 doi: 10.1016/j.intimp.2019.01.004 – ident: e_1_2_6_3_1 doi: 10.5009/gnl19312 – ident: e_1_2_6_47_1 doi: 10.1016/j.cyto.2022.155809 – ident: e_1_2_6_9_1 doi: 10.1016/j.molmet.2017.05.016 – ident: e_1_2_6_8_1 doi: 10.3390/ijms20215383 – ident: e_1_2_6_38_1 doi: 10.1038/s41420-021-00441-z – ident: e_1_2_6_28_1 doi: 10.1186/1472-6890-6-5 – ident: e_1_2_6_36_1 doi: 10.3390/antiox10020186 – ident: e_1_2_6_4_1 doi: 10.1080/15592294.2019.1699893 – ident: e_1_2_6_26_1 doi: 10.21037/atm-22-3203 – ident: e_1_2_6_82_1 doi: 10.1016/j.joca.2021.11.003 – ident: e_1_2_6_91_1 doi: 10.1016/j.arr.2019.100978 – ident: e_1_2_6_21_1 doi: 10.1111/dom.12873 – volume: 23 start-page: 10211 issue: 23 year: 2019 ident: e_1_2_6_32_1 article-title: Effect of IL‐1β on apoptosis of synovial cells in rheumatoid arthritis rats via the NF‐κB pathway publication-title: Eur Rev Med Pharmacol Sci contributor: fullname: Guo JT – volume: 40 start-page: 1709 year: 2017 ident: e_1_2_6_37_1 article-title: Isoliquiritigenin suppresses IL‐1β induced apoptosis and inflammation in chondrocyte‐like ATDC5 cells by inhibiting NF‐κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection publication-title: Int J Mol Med contributor: fullname: Ji B – ident: e_1_2_6_64_1 doi: 10.1074/jbc.M202862200 – ident: e_1_2_6_92_1 doi: 10.7717/peerj.1640 – ident: e_1_2_6_30_1 doi: 10.1016/j.intimp.2021.108048 – ident: e_1_2_6_85_1 doi: 10.1074/jbc.M107231200 – ident: e_1_2_6_55_1 doi: 10.3892/etm.2022.11267 – ident: e_1_2_6_45_1 doi: 10.1186/s13045-019-0744-3 – volume: 19 start-page: 327 issue: 1 year: 2019 ident: e_1_2_6_77_1 article-title: C‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats publication-title: Mol Med Rep contributor: fullname: Ling GQ – ident: e_1_2_6_98_1 doi: 10.1016/j.intimp.2022.108996 – ident: e_1_2_6_13_1 doi: 10.1080/15384101.2021.1911914 – ident: e_1_2_6_72_1 doi: 10.3892/etm.2021.10983 – ident: e_1_2_6_23_1 doi: 10.1016/j.jneuroim.2017.03.005 – ident: e_1_2_6_81_1 doi: 10.1007/s11626-016-0086-1 – ident: e_1_2_6_80_1 doi: 10.1038/cddis.2017.62 – ident: e_1_2_6_51_1 doi: 10.18632/oncotarget.16716 – ident: e_1_2_6_5_1 doi: 10.18632/aging.102194 |
SSID | ssj0001037308 |
Score | 2.3255591 |
SecondaryResourceType | review_article |
Snippet | Background
Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence... Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown... Abstract Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects.... BackgroundInterleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence... Evidence has shown that interleukin‐1β (IL‐1β) plays a vital role in the process of apoptosis. This paper reviews the molecular mechanisms of IL‐1β‐induced... Abstract Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects.... |
SourceID | doaj pubmedcentral proquest crossref pubmed wiley |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | e762 |
SubjectTerms | Apoptosis Arthritis Cells, Cultured Cytokines DNA methylation Endoplasmic reticulum Genes Interleukin-1beta interleukin‐1β Kinases MAPKs signaling pathway Mitochondria NF‐κB signaling pathway Oxidative stress Phosphatidylinositol 3-Kinases Phosphorylation PI3K/Akt signaling pathway Proteins Review Signal Transduction Tumor necrosis factor-TNF |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELaqSki9IH5aCBTkSohbqGPnx-FGC1UXFYQqKvVmTWxHBKFkRVKh3ngEnoUH4SF4Embs3dWuAHFBinKIrcSZiT3fODPfMPZE18I2FtpUVo1Kc-WLVFOsq20kIGAnCEAb-m_elqcX-evL4nKt1BfFhEV64Ci4Q5VBgYd1Xstc6RIy8A7Q6FpH1eRiHnlWrDlTYXdFKPx09ZJtVsjDrnPqWVXKDfsTaPr_hC1_D5Fch67B9pzcYjcXoJG_iIO9zbZ8f4fdiGUkr--yj-fDJ8-HllMwBvabyP64SAvLqeTwF7geedfz2dnPr9-yH9_xjK44KtVxmA_zaRi78Tl_B9NqKeTQO76Wm8UhpGSOu-zi5NX749N0UUMhtQX5mWC1AtHU3qHwda5RA6JufS58q4gn0hIPqCViuspWLXEweVy9q1aCUggOrdpj2_3Q-_uMO1-Ktoa21CEf1YIGaHyJgFB7b4VM2MFSsmYeqTJMJEWWhqRvUPoJOyKRr9qJ3DpcQJWbhcrNv1SesP2lwsxixo1GViUl6eb0jINVM84V-gECvR-uqE9FFHdlLhJ2L-p3NRIisivyDG9ebWh-Y6ibLX33IfBx1-jk10on7Gn4Rv768mY2e4nruXzwP4TwkO1IxFtxN2ifbU-fr_wjxEdT8zhMhV9CjhGI priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3bbtQwELVgKyReEHcCBRkJ8RbqtZPY4QVRaNVFUFUVlfpmTXyBSChZmlSov8WH8E3MJNltV1ykPMVWNJmxx8fj8RnGXphSuMpBTKWuVJqpkKeGcl1dJQEBO0EACuh_OiwOTrIPp_npFHDrprTKlU8cHLVvHcXId6Qu6BJmVsg3y-8pVY2i09WphMZ1tiXpuzO2tbt3eHR8GWURCoewWbHOCrlT11690oXcWIcGuv6_Ycw_UyWvQthhDdq_zW5N4JG_Ha19h10LzV12YywneXGPxeP2W-Bt5JSUgf16Wof8SA_LqfTwD7joeN3wxcd0_utnittxNKznsGyXfdvV3Wt-BP3aHXJoPL9yP4vDcC2zu89O9vc-vztIpzoKqctprwnOKBBVGTwawGQGrSDKGDIRoiKuSEdcoI7I6bTTkXiYAnpwHSUohQDRqQds1rRNeMS4D4WIJcTCDHdSHRiAKhQICk0ITsiEPV9p1S5Hugw7EiNLS5q3qPmE7ZK61-1EcD28aM--2Gm-WDWHHB_ng5GZMgXMIXhArOU8FRHUCdteGctOs66zl2ME5Vg343yhQxBoQntOfTTR3BWZSNjD0bZrSYjMLs_m-HG9YfUNUTdbmvrrwMld4ka_VCZhL4fx8c-ft4vFe_Tp8vH_5X_CblJd-zHWs81m_dl5eIrop6-eTUP8N4HxBvg priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELaqVkhcEOU3UJArIW4p2TiJnUoI8Vd1EUUIsVJv1sR2IKhKlk0qujcegWfhQXgInoQZJ1ntinJBinKIk9iZGdvfOJ5vGHuk8sgUBsowloUIE-HSUNFeV1PEgICdIAAt6J-8y45nyZvT9HSLjdk2BwG2l7p2lE9qtjg7uPi6fIYd_ulAIPqkqqw4kDQQ78SJSMjOTwaQ71daIoFmrEbm2bUHNuYiT9l_Gc78e7vkOoz189DRdXZtAJD8ea_xXbbl6hvsSp9ScnmTffnQnDnelJw2ZuB9Hc1FtqeI5ZR--BssW17VfPr29_cfk18_8YxuOSrYcpg3865pq_aQv4duNSxyqC1fi9Pi4MMz21tsdvT648vjcMinEJqUfE4wSkBU5M6iIlSiUBtRXrokcqUgzkhDnKCGSOqkkSXxMTkcyWUZgxAIFI24zbbrpnZ3Gbcui8ocykz52FQDCqBwGYJD5ZyJ4oDtj5LV8542Q_cEybEm6WuUfsBekMhX5UR07S80i0966DdaTCDFw1inULcqgwk4C4i5jKVkgjJge6PC9Gg8OpYZBewmVMf-qhj7Df0Mgdo153SPJLq7LIkCdqfX76olRGqXJhN8udzQ_EZTN0vq6rPn5s7R4c-FCthjbyP__Hg9nb7CsT2-999V3GdXYwRc_XLQHtvuFufuAQKkrnjo7f8PhUMWQA priority: 102 providerName: Scholars Portal – databaseName: Wiley Online Library Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3ditUwEA6yIngj_ltdJQviXd2cJG1S7_xb9ojKIi7sXZim6VqR9rDtInvnI_gsPogP4ZM4k_Z096CCUHrRpG2ayUy-pDPfMPbYFsKXHupUmlKlWoUsteTr6ksJCNgJAtCG_rv3-f6hfnOUHU1elRQLM_JDzBtupBnRXpOCQ9nvnpOGNk2lnhoyv5cR1Vga0VIfnO-vCIWDNyakE5lIdSbNmntWyN31zRuzUSTt_xvS_NNh8iKQjTPR3nV2bYKQ_Pko8xvsUmhvsitjUsmzW-zzh-5L4F3NyTUD6w00G1UjSSynBMRf4aznTcuXb399-774-QPPuDBHEVccVt1q6Pqmf8YPYJgNI4e24hcitTjEAM3-Njvce_3x5X46ZVRIfUarTvBWgSiLUKEorLYoD1HUQYtQK2KN9MQK6ommznhTEyNTQFtuaglKIVT06g7bars23GO8CrmoC6hzG6NTPViAMuQID20IXsiE7ax71q1G4gw3UiRLR73vsPcT9oK6fC4nqut4oTs5dpPmOLWADA9fBSu1sjksIFSAqMtXlE7QJGx7LTA36V_vpMkpZFfTO3bmYtQc-h0CbehOqY4hwrtci4TdHeU7t4Ro7TK9wIebDclvNHWzpG0-RXbuApf8hbIJexLHyD8_3i2Xr9C6y_v_W_EBu0q57sf9n222NZychoeIiIbyURz6vwHRkQpE priority: 102 providerName: Wiley-Blackwell |
Title | Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fiid3.762 https://www.ncbi.nlm.nih.gov/pubmed/36705417 https://www.proquest.com/docview/2769956462 https://www.proquest.com/docview/2770119640/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC9837938 https://doaj.org/article/31a51a5cde824386a1aeda273cd87407 |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB51i5C4IP4JlJUrIW67m7WT2OFGS6suYqtVRaW9RY7jlKA2WTWpUG88As_Cg_AQPAkzTrLaFXBBinyIrcSZ8c83zsw3AK9V7JvU6HzEZSpGgbDhSJGvq0m5RsBOEIAO9Oen0cl58GEZLncg7GNhnNO-SYtxeXk1LovPzrdydWUmvZ_YZDE_jNGqioWaDGAghdgw0d3Bii9w1KqeaNbnk6LIxFhGfGvrcQz9f4OVf3pHbqJWt-0cP4D7HV5k79p-PYQdWz6Cu20GydvH8OWsurSsyhn5YWC7hraerGWEZZRt-Ku-rVlRstnHX9--T3_-wBKtcNRnxvSqWjVVXdRv2UI361WQ6TJjG2FZTLtozPoJnB8ffTo8GXXpE0YmJBNTGyW0n8Y2Q7mrQKHw_Ti3gW9zQRSRhihADXHSSSNzol-yuHDLnGshEBca8RR2y6q0z4FlNvLzWOeRcqGoRiutUxshFlTWGp97sN9LNlm1LBlJy4fME5J-gtL34IBEvq4nXmt3o7q-SDrtJmKqQ7xMZhUPhIr0VNtMI8QyGeUOlB7s9QpLuslWJ1xGFJ8b0Dv219U4Tejfhy5tdUNtJLHbRYHvwbNWv-ueEIddGEzx4XJL81td3a7BkemouLuR6MEbN0b--fHJbPYel3L-4r9f8RLuUab79vRnD3ab6xv7CvFQkw5hwIMFlnIph3Dn4Oh0cTZ0ZwtYzgM1dPPjN_97FZI |
link.rule.ids | 230,315,733,786,790,870,891,2115,2236,11589,12083,21416,24346,27955,27956,31752,31753,33777,33778,43343,43838,46085,46509,50847,50956,53825,53827,74100,74657 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3bbtQwELWgCMFLxbWkFDAS4i00azuxwwviVu3CtkKolfbNmtgORELJ0qRC_S0-hG9iJsluu-Ii5Sm2ImdmPD4ej88w9szkiSsclLHQhYyVDGlsKNfVFQIQsBMEoID-4VE2PVEfFuliDLi1Y1rlyif2jto3jmLk-0JndAlTZeLV8ntMVaPodHUsoXGVXVNSKrJzvdAXMZZEogGbFedsIvaryssXOhMbq1BP1v83hPlnouRlANuvQAe32PYIHfnrQde32ZVQ32HXh2KS53dZ-bn5FnhTckrJwH4drUJ-IIflVHj4B5y3vKr5bB5Pfv2McTOOavUcls2ya9qqfck_Qbd2hhxqzy_dzuLQX8ps77GTg_fHb6fxWEUhdintNMEZCUmRB4_iN8qgDpK8DCoJpSSmSEdMoI6o6bTTJbEwBfTfuhQgJcJDJ--zrbqpwwPGfciSMocyM_2NVAcGoAgZQkITgktExJ6upGqXA1mGHWiRhSXJW5R8xN6QuNftRG_dv2hOv9hxtlg5gRQf54MRSpoMJhA8INJynkoI6ojtrZRlxznX2gsLwXGsm3G20BEI1KE5oz6aSO4ylURsZ9DteiREZZeqCX5cb2h9Y6ibLXX1tWfkznGbn0sTsee9ffzz5-1s9g49utj9__ifsBvT48O5nc-OPj5kN6nC_RD12WNb3elZeIQ4qCse98b-G5SzCH8 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3bbtQwELWgCMRLxbWkFDAS4i2s105ihxcElFUXSlUhKu2b5fgCkVCyNKlQf4sP4ZuYcbLbrrhIeYqtyPGMZ47tmTOEPFMls5U1IeWyEmkmfJ4qjHW1FTcA2BEC4IH-x6Pi4CR7v8gXY_xTN4ZVrmxiNNSutXhGPuGywCTMrOCTMIZFHO_PXi2_p1hBCm9ax3IaV8k18JIMyzjIhbw4b2EClFmt-GcZn9S1Ey9kwTc8UiTu_xva_DNo8jKYjd5odotsjzCSvh7kfptc8c0dcn0oLHl-l4RP7TdP20AxPAP69eiR3EAUS7EI8Q9z3tG6ofPDdPrrZwobcxCxo2bZLvu2q7uX9Nj0a8NITePopUwtamKCZnePnMzefX57kI4VFVKb467TWCUMq0rvQBQqUyAPVgafMR8EskZaZAW1SFMnrQzIyOTBlsvAjRAAFa24T7aatvEPCHW-YKE0oVAxO9UaZUzlC4CHynvLeEKermZVLwfiDD1QJHONM69h5hPyBqd73Y5U1_FFe_pFjytHi6nJ4bHOK54JVZip8c4A6rIOywnKhOythKXH9dfpC22BcaybYeXgdYhpfHuGfSQS3hUZS8jOINv1SJDWLs-m8HG5IfWNoW62NPXXyM5dwpa_FCohz6N-_PPn9Xy-D9ad7_5__E_IDdBzfTg_-vCQ3MRi98MB0B7Z6k_P_COARH31OOr6b7_KDKs |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+signal+transduction+pathways+in+IL%E2%80%901%CE%B2%E2%80%90induced+apoptosis%3A+Pathological+and+therapeutic+aspects&rft.jtitle=Immunity%2C+Inflammation+and+Disease&rft.au=Wang%2C+Peixuan&rft.au=Qian%2C+Hong&rft.au=Xiao%2C+Manxue&rft.au=Lv%2C+Jingwen&rft.date=2023-01-01&rft.pub=John+Wiley+and+Sons+Inc&rft.eissn=2050-4527&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1002%2Fiid3.762&rft.externalDBID=PMC9837938 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-4527&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-4527&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-4527&client=summon |