Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

• Published in: Epilepsia (Copenhagen) Vol. 49; no. 7; pp. 1239 - 1276
• Main Authors: Patsalos, Philip N., Berry, David J., Bourgeois, Blaise F. D., Cloyd, James C., Glauser, Tracy A., Johannessen, Svein I., Leppik, Ilo E., Tomson, Torbjörn, Perucca, Emilio
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.07.2008; Blackwell
• Subjects: Adolescent; Aged; Anticonvulsants - blood; Anticonvulsants - pharmacokinetics; Anticonvulsants - therapeutic use; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Biological Availability; Child; Child, Preschool; Children; Cooperative Behavior; Drug compliance; Drug Monitoring - methods; Drug Therapy, Combination; Elderly; Epilepsy - drug therapy; Half-Life; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Infant; Infant, Newborn; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Pharmacokinetics; Pharmacology. Drug treatments; Pregnancy; Reference Values; Saliva; Human; Nervous system diseases; Epilepsy; Anticonvulsant; Cerebral disorder; Pregnancy; Drug compliance; Treatment; Central nervous system disease; Children; Pharmacokinetics; Child; Elderly; Saliva; Monitoring

Summary Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies and everyday clinical experience does indicate that measuring serum concentrations of old and new generation antiepilep...