Severe cutaneous adverse drug reactions

• Published in: Journal of dermatology Vol. 43; no. 7; pp. 758 - 766
• Main Authors: Chung, Wen-Hung, Wang, Chuang-Wei, Dao, Ro-Lan
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2016; Wiley Subscription Services, Inc
• Subjects: Drug Eruptions - classification; Drug Eruptions - genetics; Drug Eruptions - immunology; Drug Eruptions - therapy; drug reaction with eosinophilia and systemic symptoms; drug-induced hypersensitivity syndrome; Humans; severe cutaneous adverse drug reactions; Side effects; Stevens-Johnson syndrome; T cell receptors; toxic epidermal necrolysis; drug reaction with eosinophilia and systemic symptoms; Stevens-Johnson syndrome; severe cutaneous adverse drug reactions; drug-induced hypersensitivity syndrome; toxic epidermal necrolysis

The clinical manifestations of drug eruptions can range from mild maculopapular exanthema to severe cutaneous adverse drug reactions (SCAR), including drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms, Stevens–Johnson syndrome (SJS) and toxic epidermal necr...