Melatonin inhibits apoptosis and improves the developmental potential of vitrified bovine oocytes

• Published in: Journal of pineal research Vol. 60; no. 2; pp. 132 - 141
• Main Authors: Zhao, Xue-Ming, Hao, Hai-Sheng, Du, Wei-Hua, Zhao, Shan-Jiang, Wang, Hao-Yu, Wang, Na, Wang, Dong, Liu, Yan, Qin, Tong, Zhu, Hua-Bin
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2016
• Subjects: Animals; Apoptosis - drug effects; bcl-2-Associated X Protein - metabolism; bcl-X Protein - metabolism; bovine; Calcium Signaling - drug effects; Caspase 3 - metabolism; Cattle; DNA Fragmentation - drug effects; Female; Gene Expression Regulation - drug effects; melatonin; Melatonin - pharmacology; Membrane Potentials - drug effects; mitochondria; oocytes; Oocytes - cytology; Oocytes - metabolism; Reactive Oxygen Species - metabolism; vitrification; bovine; melatonin; oocytes; mitochondria; vitrification

Vitrification of oocytes has been shown to be closely associated with increased levels of reactive oxygen species (ROS) and apoptotic events. However, little information is available the effect of melatonin on the ROS levels and apoptotic events in vitrified oocytes. Therefore, we studied the effect...