Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma

• Published in: Immunity, Inflammation and Disease Vol. 8; no. 4; pp. 704 - 712
• Main Authors: Jakobi, Marielena, Kiefer, Alexander, Mirzakhani, Hooman, Rauh, Manfred, Zimmermann, Theodor, Xepapadaki, Paraskevi, Stanic, Barbara, Akdis, Mubeccel, Papadopoulos, Nikolaos G., Raby, Benjamin A., Weiss, Scott T., Finotto, Susetta
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2020; John Wiley and Sons Inc; Wiley
• Subjects: Age; Allergens; Allergies; allergy processes; animals; Asthma; Blood; Cell culture; Clinical trials; Collaboration; Data collection; Eosinophils; eosinophils cells; Families & family life; Gene expression; human; Humans; Laboratories; Leukocytes, Mononuclear; Lymphocytes; NFATC Transcription Factors - metabolism; Original Research; Pediatrics; Preschool children; Spirometry; T cells; T-Lymphocytes; Transcription factors; Transplants & implants; Germany; animals; T cells; allergy processes; human; eosinophils cells
• ISSN: 2050-4527; 2050-4527
• DOI: 10.1002/iid3.360

Background We recently described increased NFATc1, IRF4, and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children and adults with multiple allergies. Objective NFATc2 has been described to associate with IRF4 to induce interleukin‐4, and to be inh...