Epithelial Na+ channel activity in human airway epithelial cells: the role of serum and glucocorticoid‐inducible kinase 1

• Published in: British journal of pharmacology Vol. 166; no. 4; pp. 1272 - 1289
• Main Authors: Watt, Gordon B, Ismail, Noor AS, Caballero, Agustin Garcia, Land, Stephen C, Wilson, Stuart M
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2012; Nature Publishing Group
• Subjects: 3‐phosphatidylinositol phosphate kinase; Biological and medical sciences; Cell Line; Dexamethasone - pharmacology; Enzyme Activation - drug effects; Enzyme Inhibitors - pharmacology; epithelial Na+ channel; Epithelial Sodium Channels - metabolism; Glucocorticoids - pharmacology; H441 cells; Humans; Immediate-Early Proteins - antagonists & inhibitors; Immediate-Early Proteins - metabolism; Kinases; Medical sciences; Membrane Potentials - drug effects; Pharmacology. Drug treatments; Phosphatidylinositol 3-Kinase - metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation - drug effects; Protein Processing, Post-Translational - drug effects; Protein Serine-Threonine Kinases - antagonists & inhibitors; Protein Serine-Threonine Kinases - metabolism; Protein Subunits - metabolism; pulmonary Na+ absorption; Research Papers; Respiratory Mucosa - drug effects; Respiratory Mucosa - enzymology; Respiratory Mucosa - metabolism; serum and glucocorticoid‐regulated kinase 1; Signal Transduction - drug effects; Sodium; Time Factors; TORC2; Transcription Factors - antagonists & inhibitors; Transcription Factors - metabolism; Up-Regulation - drug effects; Phosphates; H441 cells; Biological fluid; pulmonary Na; TORC2; Lung; channel; Ionic channel; Respiratory system; Glucocorticoid; Respiratory tract; 3-phosphatidylinositol phosphate kinase; Phosphatidylinositol; Absorption; Serum; Human; epithelial Na; Enzyme; Transferases; In vitro; Sodium; Kinase; Epithelial cell; serum and glucocorticoid-regulated kinase 1; Pharmacokinetics

BACKGROUND AND PURPOSE Glucocorticoids appear to control Na+ absorption in pulmonary epithelial cells via a mechanism dependent upon serum and glucocorticoid‐inducible kinase 1 (SGK1), a kinase that allows control over the surface abundance of epithelial Na+ channel subunits (α‐, β‐ and γ‐ENaC). How...