Comparative gene expression profiling of olfactory ensheathing cells from olfactory bulb and olfactory mucosa

• Published in: Glia Vol. 58; no. 13; pp. 1570 - 1580
• Main Authors: Guérout, Nicolas, Derambure, Céline, Drouot, Laurent, Bon-Mardion, Nicolas, Duclos, Célia, Boyer, Olivier, Marie, Jean-Paul
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2010; Wiley
• Subjects: Adult Stem Cells - classification; Adult Stem Cells - metabolism; Animals; Biochemistry, Molecular Biology; Cell Differentiation - physiology; Cells, Cultured; Data Mining - statistics & numerical data; Development; Flow Cytometry - methods; Gene expression; Gene Expression Profiling - methods; Genomics; Life Sciences; microarray; Models, Biological; Nervous system; Neuroglia - metabolism; Olfactory bulb; Olfactory Bulb - cytology; olfactory ensheathing cells; Olfactory epithelium; olfactory mucosa; Olfactory Mucosa - cytology; Oligonucleotide Array Sequence Analysis - methods; Rats; Rats, Inbred F344; Regeneration; spinal cord injury; Therapeutic applications; Wound healing

Olfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa...