Arctigenin protects mice from thioglycollate‐induced acute peritonitis

• Published in: Pharmacology research & perspectives Vol. 8; no. 5; pp. e00660 - n/a
• Main Authors: Zhao, Jingyi, Chen, Ying, Dong, Lijun, Li, Xin, Dong, Ruijie, Zhou, Dongmei, Wang, Chengzhi, Guo, Xiangdong, Zhang, Jieyou, Xue, Zhenyi, Xi, Qing, Zhang, Lijuan, Yang, Guangze, Li, Yan, Zhang, Rongxin
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.10.2020; John Wiley and Sons Inc
• Subjects: acute peritonitis; Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Apoptosis; arctigenin; Cell adhesion & migration; Chemokines; Chemokines - metabolism; Cloning; Cytokines; Disease Models, Animal; Experiments; Female; Furans - administration & dosage; Furans - pharmacology; Gene Expression Regulation - drug effects; Immune system; Inflammation; Interleukin-6 - metabolism; Kinases; L-Selectin - metabolism; Laboratory animals; Lignans - administration & dosage; Lignans - pharmacology; Lipopolysaccharides - adverse effects; macrophage; Macrophages - drug effects; Macrophages - immunology; Medical research; Mice; neutrophil; Neutrophils; Neutrophils - drug effects; Neutrophils - immunology; Original; Peritoneal dialysis; Peritonitis; Peritonitis - chemically induced; Peritonitis - drug therapy; Pharmacology; RAW 264.7 Cells; Thioglycolates - adverse effects; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Beijing China; China; macrophage; arctigenin; acute peritonitis; inflammation; neutrophil

Acute peritonitis is an acute inflammatory response of the peritoneal cavity to physical injury and chemical stimulation. Timely resolution of this response is critical to prevent further damage to the body, which can eventually lead to more severe chronic inflammation. Arctigenin (ATG) is the main...