The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines

• Published in: Frontiers in cell and developmental biology Vol. 9; p. 789427
• Main Authors: Morais, Pedro, Adachi, Hironori, Yu, Yi-Tao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.11.2021
• Subjects: Cell and Developmental Biology; COVID-19; mRNA; pseudouridine; RNA modification; SARS-CoV-2; vaccines; COVID-19; N1-methyl-pseudouridine; RNA modification; SARS-CoV-2; lipid nanoparticles; vaccines; mRNA; pseudouridine

The current COVID-19 pandemic is a massive source of global disruption, having led so far to two hundred and fifty million COVID-19 cases and almost five million deaths worldwide. It was recognized in the beginning that only an effective vaccine could lead to a way out of the pandemic, and therefore...