Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

• Published in: Cancers Vol. 12; no. 2; p. 523
• Main Authors: Sogawa, Chiharu, Eguchi, Takanori, Tran, Manh Tien, Ishige, Masayuki, Trin, Kilian, Okusha, Yuka, Taha, Eman Ahmed, Lu, Yanyin, Kawai, Hotaka, Sogawa, Norio, Takigawa, Masaharu, Calderwood, Stuart K, Okamoto, Kuniaki, Kozaki, Ken-Ichi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2020; MDPI
• Subjects: Binding sites; Cancer; Cancer therapies; Cell survival; Colorectal cancer; Cytotoxicity; Dopamine; Dopamine transporter; Drug dosages; Drug screening; Gelatinase B; Matrix metalloproteinase; Medical prognosis; Metalloproteinase; Metastases; Metastasis; NF-κB protein; Organoids; Prognosis; Stat3 protein; Stem cell transplantation; Stem cells; Tumor cells; Tumors; β-catenin; drug repositioning/repurposing; circulating tumor cell (CTC); dopamine transporter (DAT); signal transducer and activator of transcription (STAT); three-dimensional (3D) culture; benztropine; tumoroids

Tumor growth, progression, and therapy resistance are crucial factors in the prognosis of cancer. The properties of three-dimensional (3D) tumor-like organoids (tumoroids) more closely resemble in vivo tumors compared to two-dimensionally cultured cells and are therefore effectively used for assays...