Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling

• Published in: BMC developmental biology Vol. 21; no. 1; p. 10
• Main Authors: Langhans, Mark T, Gao, Jingtao, Tang, Ying, Wang, Bing, Alexander, Peter, Tuan, Rocky S
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.07.2021; BioMed Central
• Subjects: Analysis; Animals; Cadherins; Calcification; Cartilage; Cbfa-1 protein; Cell Differentiation; Cell Proliferation; Chondrocytes; Chondrogenesis; Congenital defects; Cytoskeletal Proteins - genetics; Developmental stages; Genotype & phenotype; Growth plate; Hedgehog protein; Hedgehog Proteins - genetics; Hypertrophy; Lethality; Limb buds; Limb Buds - growth & development; Mesenchyme; Mice; Mutation; N-Cadherin; Neural stem cells; Neural tube; Ossification; Osteogenesis; Phenotypes; Progenitor cells; Proliferating cell nuclear antigen; Proteins; Signal Transduction; Switzerland; Growth plate; Hedgehog; Wdpcp; Proliferation; Chondrogenesis; Differentiation; Osteogenesis; Limb bud

Mice with a loss of function mutation in Wdpcp were described previously to display severe birth defects in the developing heart, neural tube, and limb buds. Further characterization of the skeletal phenotype of Wdpcp null mice was limited by perinatal lethality. We utilized Prx1-Cre mice to generat...