An engineered superantigen SEC2 exhibits promising antitumor activity and low toxicity

• Published in: Cancer Immunology, Immunotherapy Vol. 60; no. 5; pp. 705 - 713
• Main Authors: Xu, Mingkai, Wang, Xiaogang, Cai, Yongming, Zhang, Huiwen, Yang, Hongli, Liu, Changxiao, Zhang, Chenggang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.05.2011; Springer; Springer Nature B.V
• Subjects: Animals; Antigens; Antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - immunology; Antineoplastic Agents - toxicity; Bacterial diseases; Biological and medical sciences; Cancer; Cancer Research; Cell Line, Tumor; E coli; Enterotoxins - chemistry; Enterotoxins - genetics; Enterotoxins - immunology; Enterotoxins - toxicity; Enzymes; Female; Human bacterial diseases; Immunology; Immunotherapy; Infectious diseases; Laboratory animals; Medical sciences; Medicine; Medicine & Public Health; Mice; Mice, Inbred BALB C; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Neoplasms - therapy; Oncology; Original; Original Article; Pets; Pharmacology. Drug treatments; Plasmids; Point Mutation; Protein Engineering; Rabbits; Staphylococcal infections, streptococcal infections, pneumococcal infections; Superantigens - genetics; Superantigens - immunology; Superantigens - toxicity; Toxicity; China; Superantigen; Site-directed mutagenesis; Immunotherapy; Staphylococcal enterotoxin C2; Antineoplastic agent; Toxicity; Site directed mutagenesis; Biological activity; Staphylococcus; Infection; Toxin; Treatment; Bacteriosis; Enterotoxin; Bacteria; Micrococcales; Micrococcaceae; Staphylococcal infection

Recent studies suggested that the histidine residues at 118 and 122 play an important role for the toxicity of staphylococcal enterotoxin C subtype 2 (SEC2), and the substitutions of both histidines with alanine can severely impair the fever activity of SEC2. We hypothesized that promising SEC2 anti...