Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases

Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incide...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in pharmacology Vol. 12; p. 745061
Main Authors Su, Jian-Hui, Luo, Meng-Yi, Liang, Na, Gong, Shao-Xin, Chen, Wei, Huang, Wen-Qian, Tian, Ying, Wang, Ai-Ping
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.08.2021
Subjects
atherosclerosis
IL-6Rα
inflammation
interleukin-6
ischemic stroke
Pharmacology
target
atherosclerosis
inflammation
IL-6Rα
interleukin-6
ischemic stroke
target
Online AccessGet full text

Cover

Abstract Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future. This paper is aimed to discuss the expression changes and pathological mechanisms of interleukin-6 in Cardio-Cerebrovascular Diseases, and to provide a novel strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.
AbstractList Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future. This paper is aimed to discuss the expression changes and pathological mechanisms of interleukin-6 in Cardio-Cerebrovascular Diseases, and to provide a novel strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future. This paper is aimed to discuss the expression changes and pathological mechanisms of interleukin-6 in Cardio-Cerebrovascular Diseases, and to provide a novel strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.
Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future. This paper is aimed to discuss the expression changes and pathological mechanisms of interleukin-6 in Cardio-Cerebrovascular Diseases, and to provide a novel strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.
Author Chen, Wei
Gong, Shao-Xin
Wang, Ai-Ping
Huang, Wen-Qian
Tian, Ying
Luo, Meng-Yi
Liang, Na
Su, Jian-Hui
AuthorAffiliation 2 Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Department of Physiology, Institute of Neuroscience Research, Hengyang Medical College, University of South China, Hengyang , China
1 Institute of Clinical Research, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang , China
4 Department of Pathology, First Affiliated Hospital, Hengyang Medical College, University of South China, Hengyang , China
3 Department of Anesthesiology, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang , China
AuthorAffiliation_xml – name: 4 Department of Pathology, First Affiliated Hospital, Hengyang Medical College, University of South China, Hengyang , China
– name: 3 Department of Anesthesiology, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang , China
– name: 2 Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Department of Physiology, Institute of Neuroscience Research, Hengyang Medical College, University of South China, Hengyang , China
– name: 1 Institute of Clinical Research, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang , China
Author_xml – sequence: 1
  givenname: Jian-Hui
  surname: Su
  fullname: Su, Jian-Hui
– sequence: 2
  givenname: Meng-Yi
  surname: Luo
  fullname: Luo, Meng-Yi
– sequence: 3
  givenname: Na
  surname: Liang
  fullname: Liang, Na
– sequence: 4
  givenname: Shao-Xin
  surname: Gong
  fullname: Gong, Shao-Xin
– sequence: 5
  givenname: Wei
  surname: Chen
  fullname: Chen, Wei
– sequence: 6
  givenname: Wen-Qian
  surname: Huang
  fullname: Huang, Wen-Qian
– sequence: 7
  givenname: Ying
  surname: Tian
  fullname: Tian, Ying
– sequence: 8
  givenname: Ai-Ping
  surname: Wang
  fullname: Wang, Ai-Ping
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34504432$$D View this record in MEDLINE/PubMed
BookMark eNp1kU1v1DAQhi3Uin7QH8AF5cgliz9iJ-aAtFoorFS1l3K2xvZk65KNFztZiX9P0m1Ri9S5eDSe93lHes_IUR97JOQ9owshGv2p3d1BWnDK2aKuJFXsDTllSolSN4wfPetPyEXO93QqobVQ1VtyIiZBVQl-SpbrfsDU4fgr9KX6XCyL67jHrriFtMGhaGMqVpB8iOUKE9oU95Dd2EEqvoaMkDG_I8ctdBkvHt9z8vPy2-3qR3l18329Wl6VTgo2lOh0LVULSgDzreWe1cJS5CDrVmumGXXKVfONXoHTkmomvHXArJe1r7g4J-sD10e4N7sUtpD-mAjBPAxi2hhIQ3AdGluhU7RtGLVN5aVreG2l1ADgLPO2mVhfDqzdaLfoHfZDgu4F9OVPH-7MJu5NU3EmBZ0AHx8BKf4eMQ9mG7LDroMe45gNlzXTXDR0vvvDc69_Jk8ZTAv1YcGlmHPC1rgwwBDibB06w6iZAzcPgZs5cHMIfFKy_5RP8Nc1fwHWCq7R
CitedBy_id crossref_primary_10_1080_14786419_2023_2252565
crossref_primary_10_1371_journal_pone_0296965
crossref_primary_10_1016_j_heliyon_2024_e38047
crossref_primary_10_1007_s00251_024_01332_0
crossref_primary_10_3390_biomedicines13030660
crossref_primary_10_1186_s12964_024_01594_x
crossref_primary_10_3390_ijms232415814
crossref_primary_10_1177_07334648251325623
crossref_primary_10_31482_mmsl_2024_001
crossref_primary_10_1002_iid3_818
crossref_primary_10_3389_fphys_2022_862164
crossref_primary_10_1007_s12012_025_09968_4
crossref_primary_10_1016_j_ijcard_2022_05_030
crossref_primary_10_1111_cns_14920
crossref_primary_10_1177_03000605241274626
crossref_primary_10_12677_ACM_2023_13102363
crossref_primary_10_1186_s43044_024_00568_1
crossref_primary_10_7759_cureus_42494
crossref_primary_10_1080_1744666X_2023_2174971
crossref_primary_10_1186_s40001_024_02217_4
crossref_primary_10_3390_pharmaceutics14091753
crossref_primary_10_3390_jcdd10110461
crossref_primary_10_2147_DMSO_S454018
crossref_primary_10_1186_s13019_023_02395_y
crossref_primary_10_1097_CRD_0000000000000874
crossref_primary_10_3390_jcm12030823
crossref_primary_10_1007_s11883_024_01259_7
crossref_primary_10_15829_1728_8800_2022_3094
crossref_primary_10_1002_smtd_202300426
crossref_primary_10_18087_cardio_2024_9_n2743
crossref_primary_10_3390_biomedicines11112945
crossref_primary_10_2147_JIR_S429892
crossref_primary_10_1007_s12032_024_02426_1
crossref_primary_10_61466_ijcmr2010001
crossref_primary_10_1016_j_envint_2024_108601
crossref_primary_10_31083_j_rcm2311372
crossref_primary_10_3389_fmed_2022_1027466
crossref_primary_10_3390_ijms24032483
crossref_primary_10_1186_s12883_025_04132_5
crossref_primary_10_30699_jambs_31_147_407
crossref_primary_10_1186_s12979_024_00431_6
crossref_primary_10_1016_j_jri_2024_104234
crossref_primary_10_1186_s43162_024_00288_7
crossref_primary_10_3892_etm_2022_11513
crossref_primary_10_3390_jcm12247738
crossref_primary_10_1016_j_pharmthera_2024_108670
crossref_primary_10_1152_ajpheart_00576_2023
crossref_primary_10_3390_cells11071199
crossref_primary_10_1002_prp2_1189
crossref_primary_10_1097_NRL_0000000000000483
crossref_primary_10_1016_j_envpol_2024_125008
crossref_primary_10_1111_epi_18356
crossref_primary_10_3390_jcm12134458
crossref_primary_10_1016_j_clnesp_2024_08_027
crossref_primary_10_1038_s41598_023_38762_x
crossref_primary_10_1002_advs_202417827
crossref_primary_10_1007_s10753_022_01718_w
crossref_primary_10_1007_s10741_023_10347_w
crossref_primary_10_1016_j_ajhg_2024_07_005
crossref_primary_10_1016_j_jep_2021_114799
crossref_primary_10_1038_s41598_024_61633_y
crossref_primary_10_1080_14779072_2022_2132230
crossref_primary_10_2459_JCM_0000000000001450
crossref_primary_10_1007_s10557_023_07465_w
crossref_primary_10_1042_CS20220797
crossref_primary_10_1080_14779072_2022_2074836
crossref_primary_10_3390_ijms26062753
crossref_primary_10_3390_ijms241814006
crossref_primary_10_3389_fcvm_2024_1356023
crossref_primary_10_24293_ijcpml_v29i2_1972
crossref_primary_10_3390_jcm14020496
crossref_primary_10_3389_fcvm_2024_1529903
crossref_primary_10_3389_fnagi_2022_930315
crossref_primary_10_1155_2022_8958099
crossref_primary_10_1111_jcmm_70028
crossref_primary_10_2147_DMSO_S427873
crossref_primary_10_3389_fimmu_2022_828447
crossref_primary_10_3390_endocrines5030021
crossref_primary_10_4196_kjpp_2024_28_3_285
crossref_primary_10_1186_s12891_022_05585_2
crossref_primary_10_2147_IJGM_S346482
crossref_primary_10_47360_1995_4484_2024_32_54
crossref_primary_10_1016_j_tiv_2024_105949
crossref_primary_10_12677_md_2024_143049
crossref_primary_10_3389_fphar_2024_1428406
crossref_primary_10_1177_1759720X241283340
crossref_primary_10_18087_cardio_2022_11_n2237
crossref_primary_10_1007_s11883_024_01223_5
Cites_doi 10.1038/nm1102-1235
10.1016/0002-9149(92)90603-v
10.1016/s0008-6363(02)00614-4
10.1101/cshperspect.a028456
10.1161/jaha.112.003103
10.1161/jaha.117.008024
10.1097/00004647-199909000-00008
10.1146/annurev.immunol.23.021704.115806
10.1016/s0002-9343(99)00066-2
10.1161/01.res.0000043825.01705.1b
10.1161/01.cir.92.7.1866
10.1007/s003950050007
10.1161/01.cir.91.5.1520
10.1016/j.pharmthera.2013.09.004
10.3389/fphys.2016.00125
10.2174/1381612822666160510124801
10.1016/s0735-1097(00)00912-8
10.1590/s0066-782x2008000200004
10.1016/s0021-9150(99)00463-3
10.1155/2021/6699054
10.1097/00004647-199802000-00008
10.1126/science.1631560
10.1042/bj20030407
10.1124/jpet.107.134619
10.1161/01.cir.89.3.955
10.1016/s1053-2498(00)00083-8
10.3389/fcvm.2017.00084
10.1161/jaha.116.005077
10.1016/j.jacc.2021.02.049
10.1161/01.Res.0000115557.25127.8d
10.1161/cir.0000000000000659
10.1093/eurheartj/ehz542
10.3390/jcm8111895
10.1016/s1074-7613(00)80334-9
10.1152/ajpheart.1991.260.5.H1713
10.1056/NEJMra110934510.1056/NEJMc1313604
10.1097/01.Wcb.0000055177.5044810.1097/01.WCB.0000055177.50448.FA
10.1002/cpt.782
10.3109/08830189809042997
10.1161/01.atv.19.10.2364
10.1097/00004872-200310000-00002
10.1016/j.vph.2005.08.021
10.1182/blood.v86.4.1243.bloodjournal8641243
10.2741/2759
10.1016/j.ijcard.2013.08.078
10.2217/imt-2016-0020
10.1016/j.smim.2014.01.001
10.1073/pnas.84.20.7251
10.1002/j.1460-2075.1995.tb07186.x
10.1159/000338166
10.1007/s10741-014-9431-1
10.1016/j.ejvs.2006.10.006
10.1161/hypertensionaha.109.148635
10.1093/cvr/cvn119
10.1007/s00018-020-03587-8
10.1007/s10557-005-6893-3
10.1016/j.nbd.2018.11.008
10.1016/j.atherosclerosis.2006.10.013
10.1160/th09-05-0297
10.1038/nature07201
10.1038/43219
10.1038/35025203
10.4049/jimmunol.163.7.3963
10.1097/crd.0000000000000021
10.1111/j.1749-6632.1989.tb24010.x
10.1172/jci118398
10.1016/s0735-1097(97)00494-4
10.1161/01.Cir.0000156469.96135.0d
10.1002/ejhf.1482
10.1038/nature04754
10.3389/fphys.2018.01514
10.1097/tp.0000000000001452
10.1179/174313208x341085
10.1016/j.amjmed.2014.04.015
10.1016/1043-4666(94)90013-2
10.1161/circresaha.116.308688
10.1016/j.jhep.2016.02.004
10.1016/j.ijcard.2005.06.061
10.1007/s00380-004-0770-z
10.1016/s1995-7645(14)60186-3
10.1093/eurheartj/ehu203
10.1038/mt.2014.25
10.1016/j.coi.2015.02.008
10.1016/j.cyto.2014.05.024
10.1093/cvr/cvq078
10.1016/j.surneu.2005.12.028
10.1016/0002-8703(93)90526-f
10.1007/s10741-006-9196-2
10.1007/s11897-014-0185-9
10.1016/j.jacc.2005.06.082
10.1080/14017430601164263
10.1161/01.cir.102.25.3060
10.1007/s10787-018-0458-0
10.1182/blood-2008-04-154682
10.1155/2019/7092151
10.1002/(SICI)1098-1128(199601)16:1<87::AID-MED3>3.0.CO;2-Q
10.1038/jcbfm.2012.88
10.1111/j.1365-2362.2007.01919.x
10.7150/ijbs.4666
10.1016/s1388-9842(01)00137-4
10.1161/01.Cir.0000148135.08582.97
10.1016/j.bbadis.2017.08.022
10.1371/journal.pone.0020827
10.1097/00004647-199908000-00001
10.1016/j.cardiores.2005.08.017
10.1001/jama.286.17.2107
10.5603/KP.a2018.0055
10.1038/sj.jcbfm.9600509
10.1016/j.ahj.2015.09.018
10.1016/j.atherosclerosis.2006.03.020
10.1093/toxsci/kfi101
10.1161/01.cir.99.4.546
10.1161/01.str.26.8.1393
10.1080/13814788.2017.1398320
10.1016/j.amjcard.2006.09.014
10.1016/s0735-1097(97)00116-2
10.1016/j.ijcard.2018.06.068
10.26355/eurrev_201907_18450
10.1161/01.ATV.0000214296.94849.1c
10.1016/s0304-3940(99)00051-8
10.1161/circresaha.115.307611
10.1016/j.jjcc.2018.05.010
10.1161/circresaha.115.306656
10.1161/01.cir.101.12.1372
10.1161/01.atv.19.4.972
10.1093/eurheartj/ehw171
10.1016/j.ahj.2007.09.006
10.1517/13543784.14.4.393
10.1536/ihj.15-346
10.1038/368339a0
10.1038/362801a0
10.1038/nm.3260
10.1016/j.atherosclerosis.2007.02.023
10.1096/fj.03-0331fje
10.1161/01.STR.0000200561.69611.f8
10.1161/01.res.75.2.285
10.1161/hq0901.095547
10.1007/s00395-007-0674-z
10.1016/j.cytogfr.2018.04.004
ContentType Journal Article
Copyright Copyright © 2021 Su, Luo, Liang, Gong, Chen, Huang, Tian and Wang.
Copyright © 2021 Su, Luo, Liang, Gong, Chen, Huang, Tian and Wang. 2021 Su, Luo, Liang, Gong, Chen, Huang, Tian and Wang
Copyright_xml – notice: Copyright © 2021 Su, Luo, Liang, Gong, Chen, Huang, Tian and Wang.
– notice: Copyright © 2021 Su, Luo, Liang, Gong, Chen, Huang, Tian and Wang. 2021 Su, Luo, Liang, Gong, Chen, Huang, Tian and Wang
DBID AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.3389/fphar.2021.745061
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
PubMed


CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
DocumentTitleAlternate Su et al
EISSN 1663-9812
ExternalDocumentID oai_doaj_org_article_b4ec60f810b84d5c827b559aaacb1db8
PMC8421530
34504432
10_3389_fphar_2021_745061
Genre Journal Article
Review
GrantInformation_xml – fundername: Foundation for Innovative Research Groups of the National Natural Science Foundation of China
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EMOBN
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
O5R
O5S
OK1
P2P
PGMZT
RNS
RPM
IPNFZ
NPM
RIG
7X8
5PM
ID FETCH-LOGICAL-c531t-ec9756fa63a1dfb2d173b0e2a57f991910c6c40039d6ac950913dbca1bd57d423
IEDL.DBID DOA
ISSN 1663-9812
IngestDate Wed Aug 27 01:03:16 EDT 2025
Thu Aug 21 14:12:28 EDT 2025
Fri Jul 11 00:41:21 EDT 2025
Thu Apr 03 07:06:12 EDT 2025
Tue Jul 01 03:27:33 EDT 2025
Thu Apr 24 22:59:46 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords atherosclerosis
inflammation
IL-6Rα
interleukin-6
ischemic stroke
target
Language English
License Copyright © 2021 Su, Luo, Liang, Gong, Chen, Huang, Tian and Wang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c531t-ec9756fa63a1dfb2d173b0e2a57f991910c6c40039d6ac950913dbca1bd57d423
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Reviewed by:Jun Peng, Jackpeng, China
These authors have contributed equally to this work and share first authorship
Duan-Fang Liao, Hunan University of Chinese Medicine, China
This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology
Edited by:Jian Gao, Shanghai Children’s Medical Center, China
OpenAccessLink https://doaj.org/article/b4ec60f810b84d5c827b559aaacb1db8
PMID 34504432
PQID 2571923802
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_b4ec60f810b84d5c827b559aaacb1db8
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8421530
proquest_miscellaneous_2571923802
pubmed_primary_34504432
crossref_citationtrail_10_3389_fphar_2021_745061
crossref_primary_10_3389_fphar_2021_745061
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-08-24
PublicationDateYYYYMMDD 2021-08-24
PublicationDate_xml – month: 08
  year: 2021
  text: 2021-08-24
  day: 24
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in pharmacology
PublicationTitleAlternate Front Pharmacol
PublicationYear 2021
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Ridker (B94) 2014; 35
Harris (B33) 1999; 106
Taniguchi (B118) 2014; 26
Loddick (B66) 1998; 18
Kinlay (B53) 2006; 98
Chamorro (B12) 2006; 37
Huber (B44) 1999; 19
Gwechenberger (B30) 1999; 99
Ridker (B93) 2016; 118
Wang (B125) 2005; 14
Gullestad (B29) 2012; 122
Marcus (B73) 2008; 155
Garbers (B26) 2015; 34
Halawa (B32) 1999; 101
Hartman (B34) 2014; 22
Herrmann (B38) 2003; 23
Takeda (B114) 2006; 26
Finkel (B23) 1992; 257
Hirano (B39) 1998; 16
Ikeda (B46) 1991; 260
Tanaka (B117) 2018; 10
Schett (B101) 2013; 19
Moriya (B81) 2019; 73
Tarkowski (B119) 1995; 26
Marx (B76) 1997; 30
Sakamoto (B100) 1992; 70
Yudkin (B135) 2000; 148
Keidar (B52) 2001; 21
Lusis (B68) 2000; 407
Naka (B82) 1997; 387
Westermeier (B128) 2016; 7
Koh (B59) 2005; 46
Rose-John (B97) 2017; 102
Fuchs (B25) 2003; 17
Unver (B122) 2018; 41
Wang (B126) 2019; 124
Medzhitov (B78) 2008; 454
Lu (B67) 2021; 78
Mann (B72) 2002; 91
Schieffer (B102) 2000; 101
Yudkin (B136) 1999; 19
Adibhatla (B1) 2008; 13
Held (B36) 2017; 6
Ruiz-Ruiz (B99) 2006; 112
Markousis-Mavrogenis (B74) 2019; 21
Romano (B96) 1997; 6
Akita (B3) 2017; 4
Madan (B69) 2008; 197
Zhang (B140) 2014; 22
Huo (B45) 2021; 2021
Fan (B21) 2008; 28
Martinez-Revelles (B75) 2008; 325
Zhao (B141) 2016; 118
Barton (B7) 1996; 16
Gauldie (B27) 1987; 84
Kishimoto (B56) 2005; 23
Benjamin (B8) 2019; 139
Li (B64) 2002; 8
Ridker (B95) 2020; 41
Wang (B124) 2018; 7
Eddahri (B19) 2009; 113
Kinugawa (B54) 1994; 75
Ozova (B84) 2007; 47
Mangan (B71) 2006; 441
Carlson (B11) 1999; 163
El-Adawi (B20) 2003; 57
Wu (B130) 2013; 169
Kopf (B60) 1994; 368
Schuett (B105) 2009; 102
Ross (B98) 1993; 362
Recinos (B91) 2007; 194
Kukielka (B61) 1995; 92
Dalen (B15) 2014; 127
Matsumori (B77) 1994; 89
Rauchhaus (B90) 2000; 102
Smart (B108) 2006; 69
Tsutamoto (B121) 1998; 31
Steven (B111) 2019; 2019
Barone (B6) 1999; 19
Grote (B28) 2005; 43
Tanaka (B116) 2016; 8
Lee (B63) 2005; 85
Wolf (B129) 2014; 70
Maeda (B70) 2000; 36
Iuchi (B47) 2018; 271
Tsujinaka (B120) 1996; 97
Yilmaz (B133) 2008; 30
Di Minno (B18) 2019; 8
Meléndez (B79) 2010; 56
Akbari (B2) 2018; 26
Askevold (B4) 2014; 11
Kishimoto (B55) 1995; 86
Yndestad (B134) 2006; 11
Zhang (B138) 2005; 19
Jing (B49) 2019; 23
Aulin (B5) 2015; 170
Orús (B83) 2000; 19
Shu (B107) 2007; 41
Borghetti (B9) 2018; 9
Hirano (B40) 1989; 557
Paonessa (B85) 1995; 14
Darvall (B16) 2007; 33
Piepoli (B86) 2018; 24
Heinrich (B35) 2003; 374
Fischer (B24) 2007; 102
Schieffer (B103) 2004; 110
Huang (B42) 2006; 66
Reddy (B92) 2013; 369
Hirota (B41) 2004; 19
Kobara (B58) 2010; 87
Broch (B10) 2021; 77
Seino (B106) 1994; 6
Suzuki (B112) 2008; 38
Ferrarese (B22) 1999; 19
Souza (B110) 2008; 90
Herrington (B37) 2016; 118
Kang (B51) 2008; 79
Zamani (B137) 2013; 2
Yamauchi-Takihara (B131) 1995; 91
Suzuki (B113) 1999; 262
Jordan (B50) 2017; 101
Villegas (B123) 2000; 95
Wassmann (B127) 2004; 94
Soeki (B109) 2016; 57
Plenz (B87) 2001; 3
Janssen (B48) 2005; 111
Schmidt-Arras (B104) 2016; 64
Kleveland (B57) 2016; 37
Tanaka (B115) 2012; 8
Zhang (B139) 2011; 6
Della Corte (B17) 2016; 22
Chen (B13) 2017; 1863
Lambertsen (B62) 2012; 32
Lindmark (B65) 2001; 286
Miyao (B80) 1993; 126
Yao (B132) 2014; 141
Cheng (B14) 2015; 8
Huang (B43) 2015; 20
Polak (B88) 2018; 76
Rattazzi (B89) 2003; 21
Hägg (B31) 2007; 190
References_xml – volume: 8
  start-page: 1235
  year: 2002
  ident: B64
  article-title: The Macrophage Foam Cell as a Target for Therapeutic Intervention
  publication-title: Nat. Med.
  doi: 10.1038/nm1102-1235
– volume: 70
  start-page: 271
  year: 1992
  ident: B100
  article-title: Association of Patency of the Infarct-Related Coronary Artery with Plasma Levels of Plasminogen Activator Inhibitor Activity in Acute Myocardial Infarction
  publication-title: Am. J. Cardiol.
  doi: 10.1016/0002-9149(92)90603-v
– volume: 57
  start-page: 129
  year: 2003
  ident: B20
  article-title: The Functional Role of the JAK-STAT Pathway in post-infarction Remodeling
  publication-title: Cardiovasc. Res.
  doi: 10.1016/s0008-6363(02)00614-4
– volume: 10
  year: 2018
  ident: B117
  article-title: Interleukin (IL-6) Immunotherapy
  publication-title: Cold Spring Harb Perspect. Biol.
  doi: 10.1101/cshperspect.a028456
– volume: 2
  start-page: e003103
  year: 2013
  ident: B137
  article-title: Inflammatory Biomarkers, Death, and Recurrent Nonfatal Coronary Events after an Acute Coronary Syndrome in the MIRACL Study
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/jaha.112.003103
– volume: 7
  year: 2018
  ident: B124
  article-title: Inflammation, Autophagy, and Apoptosis after Myocardial Infarction
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/jaha.117.008024
– volume: 19
  start-page: 1004
  year: 1999
  ident: B22
  article-title: Increased Cytokine Release from Peripheral Blood Cells after Acute Stroke
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1097/00004647-199909000-00008
– volume: 23
  start-page: 1
  year: 2005
  ident: B56
  article-title: Interleukin-6: from Basic Science to Medicine--40 Years in Immunology
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.23.021704.115806
– volume: 106
  start-page: 506
  year: 1999
  ident: B33
  article-title: Associations of Elevated Interleukin-6 and C-Reactive Protein Levels with Mortality in the Elderly
  publication-title: Am. J. Med.
  doi: 10.1016/s0002-9343(99)00066-2
– volume: 91
  start-page: 988
  year: 2002
  ident: B72
  article-title: Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future
  publication-title: Circ. Res.
  doi: 10.1161/01.res.0000043825.01705.1b
– volume: 92
  start-page: 1866
  year: 1995
  ident: B61
  article-title: Induction of Interleukin-6 Synthesis in the Myocardium. Potential Role in Postreperfusion Inflammatory Injury
  publication-title: Circulation
  doi: 10.1161/01.cir.92.7.1866
– volume: 95
  start-page: 47
  year: 2000
  ident: B123
  article-title: Leukemia Inhibitory Factor and Interleukin-6 Downregulate Sarcoplasmic Reticulum Ca2+ ATPase (SERCA2) in Cardiac Myocytes
  publication-title: Basic Res. Cardiol.
  doi: 10.1007/s003950050007
– volume: 91
  start-page: 1520
  year: 1995
  ident: B131
  article-title: Hypoxic Stress Induces Cardiac Myocyte-Derived Interleukin-6
  publication-title: Circulation
  doi: 10.1161/01.cir.91.5.1520
– volume: 141
  start-page: 125
  year: 2014
  ident: B132
  article-title: Targeting Interleukin-6 in Inflammatory Autoimmune Diseases and Cancers
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2013.09.004
– volume: 7
  start-page: 125
  year: 2016
  ident: B128
  article-title: New Molecular Insights of Insulin in Diabetic Cardiomyopathy
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2016.00125
– volume: 22
  start-page: 4658
  year: 2016
  ident: B17
  article-title: Inflammation, Endothelial Dysfunction and Arterial Stiffness as Therapeutic Targets in Cardiovascular Medicine
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/1381612822666160510124801
– volume: 36
  start-page: 1587
  year: 2000
  ident: B70
  article-title: High Levels of Plasma Brain Natriuretic Peptide and Interleukin-6 after Optimized Treatment for Heart Failure Are Independent Risk Factors for Morbidity and Mortality in Patients with Congestive Heart Failure
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/s0735-1097(00)00912-8
– volume: 90
  start-page: 86
  year: 2008
  ident: B110
  article-title: Serum Levels of Interleukin-6 (Il-6), Interleukin-18 (Il-18) and C-Reactive Protein (CRP) in Patients with Type-2 Diabetes and Acute Coronary Syndrome without ST-Segment Elevation
  publication-title: Arq Bras Cardiol.
  doi: 10.1590/s0066-782x2008000200004
– volume: 148
  start-page: 209
  year: 2000
  ident: B135
  article-title: Inflammation, Obesity, Stress and Coronary Heart Disease: Is Interleukin-6 the Link?
  publication-title: Atherosclerosis
  doi: 10.1016/s0021-9150(99)00463-3
– volume: 2021
  start-page: 6699054
  year: 2021
  ident: B45
  article-title: Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene
  publication-title: Oxid Med. Cel Longev
  doi: 10.1155/2021/6699054
– volume: 18
  start-page: 176
  year: 1998
  ident: B66
  article-title: Cerebral Interleukin-6 Is Neuroprotective during Permanent Focal Cerebral Ischemia in the Rat
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1097/00004647-199802000-00008
– volume: 257
  start-page: 387
  year: 1992
  ident: B23
  article-title: Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide
  publication-title: Science
  doi: 10.1126/science.1631560
– volume: 374
  start-page: 1
  year: 2003
  ident: B35
  article-title: Principles of Interleukin (IL)-6-type Cytokine Signalling and its Regulation
  publication-title: Biochem. J.
  doi: 10.1042/bj20030407
– volume: 325
  start-page: 363
  year: 2008
  ident: B75
  article-title: Endothelial Dysfunction in Rat Mesenteric Resistance Artery after Transient Middle Cerebral Artery Occlusion
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.107.134619
– volume: 89
  start-page: 955
  year: 1994
  ident: B77
  article-title: Vesnarinone, a New Inotropic Agent, Inhibits Cytokine Production by Stimulated Human Blood from Patients with Heart Failure
  publication-title: Circulation
  doi: 10.1161/01.cir.89.3.955
– volume: 19
  start-page: 419
  year: 2000
  ident: B83
  article-title: Prognostic Value of Serum Cytokines in Patients with Congestive Heart Failure
  publication-title: J. Heart Lung Transpl.
  doi: 10.1016/s1053-2498(00)00083-8
– volume: 4
  start-page: 84
  year: 2017
  ident: B3
  article-title: An Interleukin-6 Receptor Antibody Suppresses Atherosclerosis in Atherogenic Mice
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2017.00084
– volume: 6
  year: 2017
  ident: B36
  article-title: Inflammatory Biomarkers Interleukin-6 and C-Reactive Protein and Outcomes in Stable Coronary Heart Disease: Experiences from the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/jaha.116.005077
– volume: 77
  start-page: 1845
  year: 2021
  ident: B10
  article-title: Randomized Trial of Interleukin-6 Receptor Inhibition in Patients with Acute ST-Segment Elevation Myocardial Infarction
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2021.02.049
– volume: 94
  start-page: 534
  year: 2004
  ident: B127
  article-title: Interleukin-6 Induces Oxidative Stress and Endothelial Dysfunction by Overexpression of the Angiotensin II Type 1 Receptor
  publication-title: Circ. Res.
  doi: 10.1161/01.Res.0000115557.25127.8d
– volume: 139
  start-page: e56
  year: 2019
  ident: B8
  article-title: Heart Disease and Stroke Statistics-2019 Update: A Report from the American Heart Association
  publication-title: Circulation
  doi: 10.1161/cir.0000000000000659
– volume: 41
  start-page: 2153
  year: 2020
  ident: B95
  article-title: Residual Inflammatory Risk Associated with Interleukin-18 and Interleukin-6 after Successful Interleukin-1β Inhibition with Canakinumab: Further Rationale for the Development of Targeted Anti-cytokine Therapies for the Treatment of Atherothrombosis
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehz542
– volume: 8
  year: 2019
  ident: B18
  article-title: Molecular Scavengers, Oxidative Stress and Cardiovascular Disease
  publication-title: J. Clin. Med.
  doi: 10.3390/jcm8111895
– volume: 6
  start-page: 315
  year: 1997
  ident: B96
  article-title: Role of IL-6 and its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment
  publication-title: Immunity
  doi: 10.1016/s1074-7613(00)80334-9
– volume: 260
  start-page: H1713
  year: 1991
  ident: B46
  article-title: Interleukin 6 Stimulates Growth of Vascular Smooth Muscle Cells in a PDGF-dependent Manner
  publication-title: Am. J. Physiol.
  doi: 10.1152/ajpheart.1991.260.5.H1713
– volume: 369
  start-page: 2563
  year: 2013
  ident: B92
  article-title: Noncommunicable Diseases
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra110934510.1056/NEJMc1313604
– volume: 23
  start-page: 406
  year: 2003
  ident: B38
  article-title: Regulation of Body Temperature and Neuroprotection by Endogenous Interleukin-6 in Cerebral Ischemia
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1097/01.Wcb.0000055177.5044810.1097/01.WCB.0000055177.50448.FA
– volume: 102
  start-page: 591
  year: 2017
  ident: B97
  article-title: The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1002/cpt.782
– volume: 16
  start-page: 249
  year: 1998
  ident: B39
  article-title: Interleukin 6 and its Receptor: Ten Years Later
  publication-title: Int. Rev. Immunol.
  doi: 10.3109/08830189809042997
– volume: 19
  start-page: 2364
  year: 1999
  ident: B44
  article-title: Interleukin-6 Exacerbates Early Atherosclerosis in Mice
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/01.atv.19.10.2364
– volume: 21
  start-page: 1787
  year: 2003
  ident: B89
  article-title: C-reactive Protein and Interleukin-6 in Vascular Disease: Culprits or Passive Bystanders?
  publication-title: J. Hypertens.
  doi: 10.1097/00004872-200310000-00002
– volume: 43
  start-page: 357
  year: 2005
  ident: B28
  article-title: JANUS under Stress-Rrole of JAK/STAT Signaling Pathway in Vascular Diseases
  publication-title: Vascul Pharmacol.
  doi: 10.1016/j.vph.2005.08.021
– volume: 86
  start-page: 1243
  year: 1995
  ident: B55
  article-title: Interleukin-6 Family of Cytokines and Gp130
  publication-title: Blood
  doi: 10.1182/blood.v86.4.1243.bloodjournal8641243
– volume: 13
  start-page: 1250
  year: 2008
  ident: B1
  article-title: Integration of Cytokine Biology and Lipid Metabolism in Stroke
  publication-title: Front. Biosci.
  doi: 10.2741/2759
– volume: 169
  start-page: 62
  year: 2013
  ident: B130
  article-title: Association of Inflammatory Factors with Occurrence and Recurrence of Atrial Fibrillation: a Meta-Analysis
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2013.08.078
– volume: 8
  start-page: 959
  year: 2016
  ident: B116
  article-title: Immunotherapeutic Implications of IL-6 Blockade for Cytokine Storm
  publication-title: Immunotherapy
  doi: 10.2217/imt-2016-0020
– volume: 26
  start-page: 54
  year: 2014
  ident: B118
  article-title: IL-6 and Related Cytokines as the Critical Lynchpins between Inflammation and Cancer
  publication-title: Semin. Immunol.
  doi: 10.1016/j.smim.2014.01.001
– volume: 84
  start-page: 7251
  year: 1987
  ident: B27
  article-title: Interferon Beta 2/B-Cell Stimulatory Factor Type 2 Shares Identity with Monocyte-Derived Hepatocyte-Stimulating Factor and Regulates the Major Acute Phase Protein Response in Liver Cells
  publication-title: Proc. Natl. Acad. Sci. U S A.
  doi: 10.1073/pnas.84.20.7251
– volume: 14
  start-page: 1942
  year: 1995
  ident: B85
  article-title: Two Distinct and Independent Sites on IL-6 Trigger Gp 130 Dimer Formation and Signalling
  publication-title: EMBO J.
  doi: 10.1002/j.1460-2075.1995.tb07186.x
– volume: 122
  start-page: 23
  year: 2012
  ident: B29
  article-title: Inflammatory Cytokines in Heart Failure: Mediators and Markers
  publication-title: Cardiology
  doi: 10.1159/000338166
– volume: 20
  start-page: 25
  year: 2015
  ident: B43
  article-title: Role of Interleukin-6 in Regulation of Immune Responses to Remodeling after Myocardial Infarction
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-014-9431-1
– volume: 33
  start-page: 223
  year: 2007
  ident: B16
  article-title: Obesity and Thrombosis
  publication-title: Eur. J. Vasc. Endovasc Surg.
  doi: 10.1016/j.ejvs.2006.10.006
– volume: 56
  start-page: 225
  year: 2010
  ident: B79
  article-title: Interleukin 6 Mediates Myocardial Fibrosis, Concentric Hypertrophy, and Diastolic Dysfunction in Rats
  publication-title: Hypertension
  doi: 10.1161/hypertensionaha.109.148635
– volume: 79
  start-page: 671
  year: 2008
  ident: B51
  article-title: Cross-talk between Cytokines and Renin-Angiotensin in Hypothalamic Paraventricular Nucleus in Heart Failure: Role of Nuclear Factor-kappaB
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvn119
– volume: 101
  start-page: 197
  year: 1999
  ident: B32
  article-title: [Levels of Tumor Necrosis Factor (TNF-Alpha) and Interleukin 6 (IL-6) in Serum of Patients with Acute Myocardial Infarction]
  publication-title: Pol. Arch. Med. Wewn
– volume: 78
  start-page: 63
  year: 2021
  ident: B67
  article-title: Targeting the Pathways of Regulated Necrosis: a Potential Strategy for Alleviation of Cardio-Cerebrovascular Injury
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-020-03587-8
– volume: 19
  start-page: 13
  year: 2005
  ident: B138
  article-title: Simvastatin Regulates Myocardial Cytokine Expression and Improves Ventricular Remodeling in Rats after Acute Myocardial Infarction
  publication-title: Cardiovasc. Drugs Ther.
  doi: 10.1007/s10557-005-6893-3
– volume: 124
  start-page: 118
  year: 2019
  ident: B126
  article-title: Intracranial Atherosclerotic Disease
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2018.11.008
– volume: 194
  start-page: 125
  year: 2007
  ident: B91
  article-title: Angiotensin II Induces IL-6 Expression and the Jak-STAT3 Pathway in Aortic Adventitia of LDL Receptor-Deficient Mice
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2006.10.013
– volume: 102
  start-page: 215
  year: 2009
  ident: B105
  article-title: How Much Is Too Much? Interleukin-6 and its Signalling in Atherosclerosis
  publication-title: Thromb. Haemost.
  doi: 10.1160/th09-05-0297
– volume: 454
  start-page: 428
  year: 2008
  ident: B78
  article-title: Origin and Physiological Roles of Inflammation
  publication-title: Nature
  doi: 10.1038/nature07201
– volume: 387
  start-page: 924
  year: 1997
  ident: B82
  article-title: Structure and Function of a New STAT-Induced STAT Inhibitor
  publication-title: Nature
  doi: 10.1038/43219
– volume: 407
  start-page: 233
  year: 2000
  ident: B68
  article-title: Atherosclerosis
  publication-title: Nature
  doi: 10.1038/35025203
– volume: 163
  start-page: 3963
  year: 1999
  ident: B11
  article-title: Inflammatory Cytokines IL-1 Alpha, IL-1 Beta, IL-6, and TNF-Alpha Impart Neuroprotection to an Excitotoxin through Distinct Pathways
  publication-title: J. Immunol. : 1950
  doi: 10.4049/jimmunol.163.7.3963
– volume: 22
  start-page: 147
  year: 2014
  ident: B34
  article-title: Inflammation and Atherosclerosis: a Review of the Role of Interleukin-6 in the Development of Atherosclerosis and the Potential for Targeted Drug Therapy
  publication-title: Cardiol. Rev.
  doi: 10.1097/crd.0000000000000021
– volume: 557
  start-page: 167
  year: 1989
  ident: B40
  article-title: Molecular Cloning of the cDNAs for Interleukin-6/B Cell Stimulatory Factor 2 and its Receptor
  publication-title: Ann. N. Y Acad. Sci.
  doi: 10.1111/j.1749-6632.1989.tb24010.x
– volume: 97
  start-page: 244
  year: 1996
  ident: B120
  article-title: Interleukin 6 Receptor Antibody Inhibits Muscle Atrophy and Modulates Proteolytic Systems in Interleukin 6 Transgenic Mice
  publication-title: J. Clin. Invest.
  doi: 10.1172/jci118398
– volume: 31
  start-page: 391
  year: 1998
  ident: B121
  article-title: Interleukin-6 Spillover in the Peripheral Circulation Increases with the Severity of Heart Failure, and the High Plasma Level of Interleukin-6 Is an Important Prognostic Predictor in Patients with Congestive Heart Failure
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/s0735-1097(97)00494-4
– volume: 111
  start-page: 996
  year: 2005
  ident: B48
  article-title: Interleukin-6 Causes Myocardial Failure and Skeletal Muscle Atrophy in Rats
  publication-title: Circulation
  doi: 10.1161/01.Cir.0000156469.96135.0d
– volume: 21
  start-page: 965
  year: 2019
  ident: B74
  article-title: The Clinical Significance of Interleukin-6 in Heart Failure: Results from the BIOSTAT-CHF Study
  publication-title: Eur. J. Heart Fail.
  doi: 10.1002/ejhf.1482
– volume: 441
  start-page: 231
  year: 2006
  ident: B71
  article-title: Transforming Growth Factor-Beta Induces Development of the T(H)17 Lineage
  publication-title: Nature
  doi: 10.1038/nature04754
– volume: 9
  start-page: 1514
  year: 2018
  ident: B9
  article-title: Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2018.01514
– volume: 101
  start-page: 32
  year: 2017
  ident: B50
  article-title: Interleukin-6, A Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft Rejection: Therapeutic Implications of IL-6 Receptor Blockade
  publication-title: Transplantation
  doi: 10.1097/tp.0000000000001452
– volume: 30
  start-page: 783
  year: 2008
  ident: B133
  article-title: Cell Adhesion Molecules and Ischemic Stroke
  publication-title: Neurol. Res.
  doi: 10.1179/174313208x341085
– volume: 127
  start-page: 807
  year: 2014
  ident: B15
  article-title: The Epidemic of the 20(th) century: Coronary Heart Disease
  publication-title: Am. J. Med.
  doi: 10.1016/j.amjmed.2014.04.015
– volume: 6
  start-page: 87
  year: 1994
  ident: B106
  article-title: Interleukin 6 Gene Transcripts Are Expressed in Human Atherosclerotic Lesions
  publication-title: Cytokine
  doi: 10.1016/1043-4666(94)90013-2
– volume: 118
  start-page: 1918
  year: 2016
  ident: B141
  article-title: Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and Dysfunction
  publication-title: Circ. Res.
  doi: 10.1161/circresaha.116.308688
– volume: 64
  start-page: 1403
  year: 2016
  ident: B104
  article-title: IL-6 Pathway in the Liver: From Physiopathology to Therapy
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.02.004
– volume: 112
  start-page: 112
  year: 2006
  ident: B99
  article-title: Time-course of Changes in Levels of Interleukin 6 in Acutely Decompensated Heart Failure
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2005.06.061
– volume: 19
  start-page: 237
  year: 2004
  ident: B41
  article-title: Circulating Interleukin-6 Family Cytokines and Their Receptors in Patients with Congestive Heart Failure
  publication-title: Heart Vessels
  doi: 10.1007/s00380-004-0770-z
– volume: 8
  start-page: 48
  year: 2015
  ident: B14
  article-title: Protective Function of Tocilizumab in Human Cardiac Myocytes Ischemia Reperfusion Injury
  publication-title: Asian Pac. J. Trop. Med.
  doi: 10.1016/s1995-7645(14)60186-3
– volume: 47
  start-page: 52
  year: 2007
  ident: B84
  article-title: [Inflammation and Chronic Heart Failure. The Role of Statins]
  publication-title: Kardiologiia
– volume: 35
  start-page: 1782
  year: 2014
  ident: B94
  article-title: Anti-inflammatory Therapies for Cardiovascular Disease
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehu203
– volume: 22
  start-page: 974
  year: 2014
  ident: B140
  article-title: miR-29b as a Therapeutic Agent for Angiotensin II-Induced Cardiac Fibrosis by Targeting TGF-β/Smad3 Signaling
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2014.25
– volume: 34
  start-page: 75
  year: 2015
  ident: B26
  article-title: The IL-6/gp130/STAT3 Signaling axis: Recent Advances towards Specific Inhibition
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2015.02.008
– volume: 70
  start-page: 11
  year: 2014
  ident: B129
  article-title: Interleukin-6 and its Receptors: a Highly Regulated and Dynamic System
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2014.05.024
– volume: 87
  start-page: 424
  year: 2010
  ident: B58
  article-title: Antibody against Interleukin-6 Receptor Attenuates Left Ventricular Remodelling after Myocardial Infarction in Mice
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvq078
– volume: 66
  start-page: 232
  year: 2006
  ident: B42
  article-title: Inflammation in Stroke and Focal Cerebral Ischemia
  publication-title: Surg. Neurol.
  doi: 10.1016/j.surneu.2005.12.028
– volume: 126
  start-page: 1299
  year: 1993
  ident: B80
  article-title: Elevated Plasma Interleukin-6 Levels in Patients with Acute Myocardial Infarction
  publication-title: Am. Heart J.
  doi: 10.1016/0002-8703(93)90526-f
– volume: 11
  start-page: 83
  year: 2006
  ident: B134
  article-title: Systemic Inflammation in Heart Failure-Tthe Whys and Wherefores
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-006-9196-2
– volume: 11
  start-page: 146
  year: 2014
  ident: B4
  article-title: Interleukin-6 Signaling, Soluble Glycoprotein 130, and Inflammation in Heart Failure
  publication-title: Curr. Heart Fail. Rep.
  doi: 10.1007/s11897-014-0185-9
– volume: 46
  start-page: 1978
  year: 2005
  ident: B59
  article-title: Inflammatory Markers and the Metabolic Syndrome: Insights from Therapeutic Interventions
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2005.06.082
– volume: 41
  start-page: 149
  year: 2007
  ident: B107
  article-title: Increased Levels of Interleukin-6 and Matrix Metalloproteinase-9 Are of Cardiac Origin in Acute Coronary Syndrome
  publication-title: Scand. Cardiovasc. J.
  doi: 10.1080/14017430601164263
– volume: 102
  start-page: 3060
  year: 2000
  ident: B90
  article-title: Plasma Cytokine Parameters and Mortality in Patients with Chronic Heart Failure
  publication-title: Circulation
  doi: 10.1161/01.cir.102.25.3060
– volume: 26
  start-page: 685
  year: 2018
  ident: B2
  article-title: IL-6 Signalling Pathways and the Development of Type 2 Diabetes
  publication-title: Inflammopharmacology
  doi: 10.1007/s10787-018-0458-0
– volume: 113
  start-page: 2426
  year: 2009
  ident: B19
  article-title: Interleukin-6/STAT3 Signaling Regulates the Ability of Naive T Cells to Acquire B-Cell Help Capacities
  publication-title: Blood
  doi: 10.1182/blood-2008-04-154682
– volume: 2019
  start-page: 7092151
  year: 2019
  ident: B111
  article-title: Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
  publication-title: Oxid Med. Cel Longev
  doi: 10.1155/2019/7092151
– volume: 16
  start-page: 87
  year: 1996
  ident: B7
  article-title: The Biological Effects of Interleukin 6
  publication-title: Med. Res. Rev.
  doi: 10.1002/(SICI)1098-1128(199601)16:1<87::AID-MED3>3.0.CO;2-Q
– volume: 32
  start-page: 1677
  year: 2012
  ident: B62
  article-title: Inflammatory Cytokines in Experimental and Human Stroke
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2012.88
– volume: 38
  start-page: 166
  year: 2008
  ident: B112
  article-title: Elevation of Matrix Metalloproteinases and Interleukin-6 in the Culprit Coronary Artery of Myocardial Infarction
  publication-title: Eur. J. Clin. Invest.
  doi: 10.1111/j.1365-2362.2007.01919.x
– volume: 8
  start-page: 1227
  year: 2012
  ident: B115
  article-title: Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.4666
– volume: 3
  start-page: 415
  year: 2001
  ident: B87
  article-title: Activation of the Cardiac Interleukin-6 System in Advanced Heart Failure
  publication-title: Eur. J. Heart Fail.
  doi: 10.1016/s1388-9842(01)00137-4
– volume: 110
  start-page: 3493
  year: 2004
  ident: B103
  article-title: Impact of Interleukin-6 on Plaque Development and Morphology in Experimental Atherosclerosis
  publication-title: Circulation
  doi: 10.1161/01.Cir.0000148135.08582.97
– volume: 1863
  start-page: 3128
  year: 2017
  ident: B13
  article-title: Interleukin-6 Deficiency Facilitates Myocardial Dysfunction during High Fat Diet-Induced Obesity by Promoting Lipotoxicity and Inflammation
  publication-title: Biochim. Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2017.08.022
– volume: 6
  start-page: e20827
  year: 2011
  ident: B139
  article-title: Long-term Exposure to Ambient Air Pollution and Mortality Due to Cardiovascular Disease and Cerebrovascular Disease in Shenyang, China
  publication-title: PloS one
  doi: 10.1371/journal.pone.0020827
– volume: 19
  start-page: 819
  year: 1999
  ident: B6
  article-title: Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1097/00004647-199908000-00001
– volume: 69
  start-page: 164
  year: 2006
  ident: B108
  article-title: IL-6 Induces PI 3-kinase and Nitric Oxide-dependent protection and Preserves Mitochondrial Function in Cardiomyocytes
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2005.08.017
– volume: 286
  start-page: 2107
  year: 2001
  ident: B65
  article-title: Relationship between Interleukin 6 and Mortality in Patients with Unstable Coronary Artery Disease: Effects of an Early Invasive or Noninvasive Strategy
  publication-title: JAMA
  doi: 10.1001/jama.286.17.2107
– volume: 76
  start-page: 1055
  year: 2018
  ident: B88
  article-title: Cardiovascular Risk Assessment, Cardiovascular Disease Risk Factors, and Lung Function Parameters
  publication-title: Kardiol Pol.
  doi: 10.5603/KP.a2018.0055
– volume: 28
  start-page: 90
  year: 2008
  ident: B21
  article-title: Interleukin-6 Stimulates Circulating Blood-Derived Endothelial Progenitor Cell Angiogenesis In Vitro
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/sj.jcbfm.9600509
– volume: 170
  start-page: 1151
  year: 2015
  ident: B5
  article-title: Interleukin-6 and C-Reactive Protein and Risk for Death and Cardiovascular Events in Patients with Atrial Fibrillation
  publication-title: Am. Heart J.
  doi: 10.1016/j.ahj.2015.09.018
– volume: 190
  start-page: 291
  year: 2007
  ident: B31
  article-title: Augmented Levels of CD44 in Macrophages from Atherosclerotic Subjects: a Possible IL-6-CD44 Feedback Loop?
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2006.03.020
– volume: 85
  start-page: 541
  year: 2005
  ident: B63
  article-title: Oxidative Stress Mediates Sodium Arsenite-Induced Expression of Heme Oxygenase-1, Monocyte Chemoattractant Protein-1, and Interleukin-6 in Vascular Smooth Muscle Cells
  publication-title: Toxicol. Sci.
  doi: 10.1093/toxsci/kfi101
– volume: 99
  start-page: 546
  year: 1999
  ident: B30
  article-title: Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions
  publication-title: Circulation
  doi: 10.1161/01.cir.99.4.546
– volume: 26
  start-page: 1393
  year: 1995
  ident: B119
  article-title: Early Intrathecal Production of Interleukin-6 Predicts the Size of Brain Lesion in Stroke
  publication-title: Stroke
  doi: 10.1161/01.str.26.8.1393
– volume: 24
  start-page: 51
  year: 2018
  ident: B86
  article-title: Main Messages for Primary Care from the 2016 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice
  publication-title: Eur. J. Gen. Pract.
  doi: 10.1080/13814788.2017.1398320
– volume: 98
  start-page: 2P
  year: 2006
  ident: B53
  article-title: Inflammatory Biomarkers in Stable Atherosclerosis
  publication-title: Am. J. Cardiol.
  doi: 10.1016/j.amjcard.2006.09.014
– volume: 30
  start-page: 165
  year: 1997
  ident: B76
  article-title: Induction of Cytokine Expression in Leukocytes in Acute Myocardial Infarction
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/s0735-1097(97)00116-2
– volume: 271
  start-page: 19
  year: 2018
  ident: B47
  article-title: IL-6 Blockade for Myocardial Infarction
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2018.06.068
– volume: 23
  start-page: 6283
  year: 2019
  ident: B49
  article-title: IL-6 Knockout Ameliorates Myocardial Remodeling after Myocardial Infarction by Regulating Activation of M2 Macrophages and Fibroblast Cells
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  doi: 10.26355/eurrev_201907_18450
– volume: 26
  start-page: 1177
  year: 2006
  ident: B114
  article-title: Synthetic Retinoid Am80 Reduces Scavenger Receptor Expression and Atherosclerosis in Mice by Inhibiting IL-6
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000214296.94849.1c
– volume: 262
  start-page: 117
  year: 1999
  ident: B113
  article-title: Cerebral Neurons Express Interleukin-6 after Transient Forebrain Ischemia in Gerbils
  publication-title: Neurosci. Lett.
  doi: 10.1016/s0304-3940(99)00051-8
– volume: 118
  start-page: 535
  year: 2016
  ident: B37
  article-title: Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease
  publication-title: Circ. Res.
  doi: 10.1161/circresaha.115.307611
– volume: 73
  start-page: 22
  year: 2019
  ident: B81
  article-title: Critical Roles of Inflammation in Atherosclerosis
  publication-title: J. Cardiol.
  doi: 10.1016/j.jjcc.2018.05.010
– volume: 118
  start-page: 145
  year: 2016
  ident: B93
  article-title: From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream to Identify Novel Targets for Atheroprotection
  publication-title: Circ. Res.
  doi: 10.1161/circresaha.115.306656
– volume: 101
  start-page: 1372
  year: 2000
  ident: B102
  article-title: Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques: Potential Implications for Inflammation and Plaque Instability
  publication-title: Circulation
  doi: 10.1161/01.cir.101.12.1372
– volume: 19
  start-page: 972
  year: 1999
  ident: B136
  article-title: C-reactive Protein in Healthy Subjects: Associations with Obesity, Insulin Resistance, and Endothelial Dysfunction: a Potential Role for Cytokines Originating from Adipose Tissue?
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/01.atv.19.4.972
– volume: 37
  start-page: 2406
  year: 2016
  ident: B57
  article-title: Effect of a Single Dose of the Interleukin-6 Receptor Antagonist Tocilizumab on Inflammation and Troponin T Release in Patients with Non-ST-elevation Myocardial Infarction: a Double-Blind, Randomized, Placebo-Controlled Phase 2 Trial
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehw171
– volume: 155
  start-page: 303
  year: 2008
  ident: B73
  article-title: Interleukin-6 and Atrial Fibrillation in Patients with Coronary Artery Disease: Data from the Heart and Soul Study
  publication-title: Am. Heart J.
  doi: 10.1016/j.ahj.2007.09.006
– volume: 14
  start-page: 393
  year: 2005
  ident: B125
  article-title: Investigational Anti-inflammatory Agents for the Treatment of Ischaemic Brain Injury
  publication-title: Expert Opin. Investig. Drugs
  doi: 10.1517/13543784.14.4.393
– volume: 57
  start-page: 134
  year: 2016
  ident: B109
  article-title: Inflammatory Biomarkers and Atherosclerosis
  publication-title: Int. Heart J.
  doi: 10.1536/ihj.15-346
– volume: 368
  start-page: 339
  year: 1994
  ident: B60
  article-title: Impaired Immune and Acute-phase Responses in Interleukin-6-Deficient Mice
  publication-title: Nature
  doi: 10.1038/368339a0
– volume: 362
  start-page: 801
  year: 1993
  ident: B98
  article-title: The Pathogenesis of Atherosclerosis: a Perspective for the 1990s
  publication-title: Nature
  doi: 10.1038/362801a0
– volume: 19
  start-page: 822
  year: 2013
  ident: B101
  article-title: How Cytokine Networks Fuel Inflammation: Toward a Cytokine-Based Disease Taxonomy
  publication-title: Nat. Med.
  doi: 10.1038/nm.3260
– volume: 197
  start-page: 504
  year: 2008
  ident: B69
  article-title: Atheroprotective Role of Interleukin-6 in Diet- And/or Pathogen-Associated Atherosclerosis Using an ApoE Heterozygote Murine Model
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2007.02.023
– volume: 17
  start-page: 2118
  year: 2003
  ident: B25
  article-title: Role of Interleukin-6 for LV Remodeling and Survival after Experimental Myocardial Infarction
  publication-title: FASEB J.
  doi: 10.1096/fj.03-0331fje
– volume: 37
  start-page: 291
  year: 2006
  ident: B12
  article-title: The Harms and Benefits of Inflammatory and Immune Responses in Vascular Disease
  publication-title: Stroke
  doi: 10.1161/01.STR.0000200561.69611.f8
– volume: 75
  start-page: 285
  year: 1994
  ident: B54
  article-title: Nitric Oxide-Mediated Effects of Interleukin-6 on [Ca2+]i and Cell Contraction in Cultured Chick Ventricular Myocytes
  publication-title: Circ. Res.
  doi: 10.1161/01.res.75.2.285
– volume: 21
  start-page: 1464
  year: 2001
  ident: B52
  article-title: Angiotensin II Administration to Atherosclerotic Mice Increases Macrophage Uptake of Oxidized Ldl: a Possible Role for Interleukin-6
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/hq0901.095547
– volume: 102
  start-page: 393
  year: 2007
  ident: B24
  article-title: Survival Pathways in Hypertrophy and Heart Failure: the Gp130-STAT axis
  publication-title: Basic Res. Cardiol.
  doi: 10.1007/s00395-007-0674-z
– volume: 41
  start-page: 10
  year: 2018
  ident: B122
  article-title: IL-6 Family Cytokines: Key Inflammatory Mediators as Biomarkers and Potential Therapeutic Targets
  publication-title: Cytokine Growth Factor. Rev.
  doi: 10.1016/j.cytogfr.2018.04.004
SSID ssj0000399364
Score 2.5514584
SecondaryResourceType review_article
Snippet Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 745061
SubjectTerms atherosclerosis
IL-6Rα
inflammation
interleukin-6
ischemic stroke
Pharmacology
target
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhufRS-u72hQolhxKltiVLdiCU7bYhFBJy2IXchJ5J6OJN91G6_z4zsnfTLUtPvVoWHmY0mm-k8TeEfODRltLJknFRcyYcF6yyNmcFhgfvhYnpHPLsXJ6OxPfL8nKHrNpbdQqcbU3tsJ_UaDo-_P1z-Rkc_hgzToi3n-LttUFqzyI_VKLMMBnag8Ck0E_POrSfNmYMxlK0d5vbZ25Ep0Tivw15_l1A-UdEOnlEHnZQkvZb2z8mO6F5QvYvWi7q5QEd3v9aNTug-_TinqV6-ZT001ngOCx-3DRMHtE-PZ_8CmM6TKXhFLAsHaRaVTYIU0ic1zWr9Gt7pzN7RkYn34aDU9b1U2AOPG3OgqtVKaOR3OQ-2sLnitssFKZUEWAiAAcnnUA1eWlcjVCCe-tMbn2pPOCu52S3mTThJaFcxRKwAWRnYEtnijr4EHluvBGm5lnVI9lKj9p1ZOPY82KsIelA1eukeo2q163qe-Tjespty7Txr5e_oHHWLyJJdnowmV7pzue0FcHJLFZ5ZivhS1cVykICZYxxNvcWhHy_Mq0Gp8KbEtOEyWKmYR9D5FtlRY-8aE29_hQHAYTgMKI2FsGGLJsjzc11Iu6uBAAsnr36H8K_Jg9QH3i8XYg3ZHc-XYS3gI_m9l1a9Xe0ZxBC
  priority: 102
  providerName: Scholars Portal
Title Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases
URI https://www.ncbi.nlm.nih.gov/pubmed/34504432
https://www.proquest.com/docview/2571923802
https://pubmed.ncbi.nlm.nih.gov/PMC8421530
https://doaj.org/article/b4ec60f810b84d5c827b559aaacb1db8
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LSyQxEA7iyYus-3J0XbIgHhajnc6ju72NoyILiocRvIU8UXboGZyZBf_9VpJ5yrJevPShk6aLqkrqq6TyBaFDFoyQVgrCeMMIt4yT2hhKyhgenOM6pHXIm1t5fc9_PYiHlau-Yk1YpgfOijs13FtZhJoWpuZO2LqsDKBgrbU11Jl0zBdi3koylebgGHclz9uYkIU1p2H0qCP_Z0lPKi4KSdcCUeLr_xfIfF0ruRJ8rj6g7RlqxN0s7Q7a8O1HdHSXaadfjnF_eYpqfIyP8N2SkPrlE-qmZb-Bn_5-aok8w118O_zjB7ifqsAxwFbcS2WppOefIUdelKfii7x9M_6M7q8u-71rMrs6gVgYVBPibVMJGbRkmrpgSkcrZgpfalEFQISAEay0PKrJSW2biBqYM1ZT40TlAGJ9QZvtsPW7CLMqCIABkIiB2awuG-98YFQ7zXXDirqDirkelZ3xisfrLQYK8ouoepVUr6LqVVZ9B_1cfDLKpBr_63wejbPoGPmw0wvwEjXzEvWWl3TQj7lpFYyfuCmiWz-cjhVMWRHk1kXZQV-zqRe_YiAA5wxaqjUnWJNlvaV9ekwc3TUHLMWKvfcQfh9tRX3EleySf0Obk-epPwAoNDHfk9fD84bXfwHxcAlc
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-6%3A+A+Novel+Target+for+Cardio-Cerebrovascular+Diseases&rft.jtitle=Frontiers+in+pharmacology&rft.au=Jian-Hui+Su&rft.au=Jian-Hui+Su&rft.au=Meng-Yi+Luo&rft.au=Meng-Yi+Luo&rft.date=2021-08-24&rft.pub=Frontiers+Media+S.A&rft.eissn=1663-9812&rft.volume=12&rft_id=info:doi/10.3389%2Ffphar.2021.745061&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_b4ec60f810b84d5c827b559aaacb1db8
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-9812&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-9812&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-9812&client=summon