The influence of rigid gas permeable lens wear on the concentrations of dinucleotides in tears and the effect on dry eye signs and symptoms in keratoconus

• Published in: Contact lens & anterior eye Vol. 39; no. 5; pp. 375 - 379
• Main Authors: Carracedo, Gonzalo, González-Méijome, José Manuel, Martín-Gil, Alba, Carballo, Jesús, Pintor, Jesús
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2016
• Subjects: Adult; Biomarkers - analysis; Contact Lenses - adverse effects; Dinucleoside Phosphates - analysis; Dry eye; Dry Eye Syndromes - diagnosis; Dry Eye Syndromes - etiology; Dry Eye Syndromes - metabolism; Female; Gases - chemistry; GP lenses; Humans; Keratoconus; Keratoconus - complications; Keratoconus - metabolism; Keratoconus - therapy; Male; Middle Aged; Nucleotides; Ophthalmology; Permeability; Reproducibility of Results; Sensitivity and Specificity; Symptom Assessment; Tears - chemistry; Young Adult; Nucleotides; Keratoconus; Dry eye; GP lenses

•Ap4A, Ap5A and dry eye symptoms increase in keratoconus vs. healthy subjects.•RGP wearing exacerbates the signs and symptoms of dry eye in keratoconus patients.•RGP lens wear increases the Ap4A concentration in the tears of keratoconus patients. To evaluate the signs and symptoms of dry eye and din...