Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases

• Published in: Frontiers in molecular biosciences Vol. 9; p. 791094
• Main Authors: Akiyama, Yasutoshi, Lyons, Shawn M, Fay, Marta M, Tomioka, Yoshihisa, Abe, Takaaki, Anderson, Paul J, Ivanov, Pavel
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.03.2022
• Subjects: angiogenin; CCA-terminus; Molecular Biosciences; RNase A superfamily; stress response; tRNAs; angiogenin; stress response; tRNAs; CCA-terminus; RNase A superfamily

Stress-induced tRNA cleavage has been implicated in various cellular processes, where tRNA fragments play diverse regulatory roles. Angiogenin (ANG), a member of the RNase A superfamily, induces cleavage of tRNAs resulting in the formation of tRNA-derived stress-induced RNAs (tiRNAs) that contribute...