NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis

• Published in: Frontiers in immunology Vol. 12; p. 749979
• Main Authors: Guo, Xinyue, Xu, Xinxin, Li, Tiantian, Yu, Qin, Wang, Jianzhang, Chen, Yichen, Ding, Shaojie, Zhu, Libo, Zou, Gen, Zhang, Xinmei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 22.09.2021
• Subjects: Animals; Cell Line; endometriosis; Endometriosis - immunology; Estradiol - pharmacology; estrogen; Estrogen Receptor alpha - genetics; Estrogens - pharmacology; Female; Humans; Immunology; Inflammasomes - antagonists & inhibitors; Inflammasomes - genetics; Inflammasomes - immunology; Interleukin-1beta - immunology; interleukin-1β; mast cells; Mast Cells - drug effects; Mast Cells - immunology; Mice; Mice, Inbred BALB C; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; NLRP3 inflammasome; Peritoneal Cavity - cytology; Signal Transduction - drug effects; Thiazolidines - pharmacology; Thiones - pharmacology; endometriosis; estrogen; NLRP3 inflammasome; mast cells; interleukin-1β

Endometriosis is an estrogen-dependent gynecological disease. The pathogenesis of endometriosis remains controversial, although it is generally accepted that the inflammatory immune response plays a crucial role in this process. Mast cells (MCs) are multifunctional innate immune cells that accumulat...