Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes

Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet t...

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Published inFrontiers in endocrinology (Lausanne) Vol. 12; p. 732431
Main Authors Cayabyab, Fritz, Nih, Lina R., Yoshihara, Eiji
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.09.2021
Subjects
Animals
biomaterials
diabetes
Diabetes Mellitus, Type 1 - therapy
Endocrinology
Graft Survival
Humans
islet transplantation
Islets of Langerhans - physiology
Islets of Langerhans Transplantation - methods
Islets of Langerhans Transplantation - trends
stem cells
vascularization
stem cells
islet transplantation
vascularization
biomaterials
diabetes
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Abstract Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet transplantation holds great promise in the treatment of T1D; however, the difficulty in regulating post-transplantation immune reactions to avoid both allogenic and autoimmune graft rejection represent a bottleneck in the field of islet transplantation. Cell replacement strategies have been performed in hepatic, intramuscular, omentum, and subcutaneous sites, and have been performed in both animal models and human patients. However more optimal transplantation sites and methods of improving islet graft survival are needed to successfully translate these studies to a clinical relevant therapy. In this review, we summarize the current progress in the field as well as methods and sites of islet transplantation, including stem cell-derived functional human islets. We also discuss the contribution of immune cells, vessel formation, extracellular matrix, and nutritional supply on islet graft survival. Developing new transplantation sites with emerging technologies to improve islet graft survival and simplify immune regulation will greatly benefit the future success of islet cell therapy in the treatment of diabetes.
AbstractList Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet transplantation holds great promise in the treatment of T1D; however, the difficulty in regulating post-transplantation immune reactions to avoid both allogenic and autoimmune graft rejection represent a bottleneck in the field of islet transplantation. Cell replacement strategies have been performed in hepatic, intramuscular, omentum, and subcutaneous sites, and have been performed in both animal models and human patients. However more optimal transplantation sites and methods of improving islet graft survival are needed to successfully translate these studies to a clinical relevant therapy. In this review, we summarize the current progress in the field as well as methods and sites of islet transplantation, including stem cell-derived functional human islets. We also discuss the contribution of immune cells, vessel formation, extracellular matrix, and nutritional supply on islet graft survival. Developing new transplantation sites with emerging technologies to improve islet graft survival and simplify immune regulation will greatly benefit the future success of islet cell therapy in the treatment of diabetes.
Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet transplantation holds great promise in the treatment of T1D; however, the difficulty in regulating post-transplantation immune reactions to avoid both allogenic and autoimmune graft rejection represent a bottleneck in the field of islet transplantation. Cell replacement strategies have been performed in hepatic, intramuscular, omentum, and subcutaneous sites, and have been performed in both animal models and human patients. However more optimal transplantation sites and methods of improving islet graft survival are needed to successfully translate these studies to a clinical relevant therapy. In this review, we summarize the current progress in the field as well as methods and sites of islet transplantation, including stem cell-derived functional human islets. We also discuss the contribution of immune cells, vessel formation, extracellular matrix, and nutritional supply on islet graft survival. Developing new transplantation sites with emerging technologies to improve islet graft survival and simplify immune regulation will greatly benefit the future success of islet cell therapy in the treatment of diabetes.Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet transplantation holds great promise in the treatment of T1D; however, the difficulty in regulating post-transplantation immune reactions to avoid both allogenic and autoimmune graft rejection represent a bottleneck in the field of islet transplantation. Cell replacement strategies have been performed in hepatic, intramuscular, omentum, and subcutaneous sites, and have been performed in both animal models and human patients. However more optimal transplantation sites and methods of improving islet graft survival are needed to successfully translate these studies to a clinical relevant therapy. In this review, we summarize the current progress in the field as well as methods and sites of islet transplantation, including stem cell-derived functional human islets. We also discuss the contribution of immune cells, vessel formation, extracellular matrix, and nutritional supply on islet graft survival. Developing new transplantation sites with emerging technologies to improve islet graft survival and simplify immune regulation will greatly benefit the future success of islet cell therapy in the treatment of diabetes.
Author Cayabyab, Fritz
Nih, Lina R.
Yoshihara, Eiji
AuthorAffiliation 2 David Geffen School of Medicine at University of California , Los Angeles, CA , United States
1 Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center , Torrance, CA , United States
AuthorAffiliation_xml – name: 2 David Geffen School of Medicine at University of California , Los Angeles, CA , United States
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  fullname: Yoshihara, Eiji
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Keywords stem cells
islet transplantation
vascularization
biomaterials
diabetes
Language English
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This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology
Edited by: Anca Dana Dobrian, Eastern Virginia Medical School, United States
Reviewed by: Takayuki Anazawa, Kyoto University, Japan; Gumpei Yoshimatsu, Fukuoka University, Japan
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Snippet Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required...
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proquest
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SubjectTerms Animals
biomaterials
diabetes
Diabetes Mellitus, Type 1 - therapy
Endocrinology
Graft Survival
Humans
islet transplantation
Islets of Langerhans - physiology
Islets of Langerhans Transplantation - methods
Islets of Langerhans Transplantation - trends
stem cells
vascularization
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Title Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes
URI https://www.ncbi.nlm.nih.gov/pubmed/34589059
https://www.proquest.com/docview/2578152737
https://pubmed.ncbi.nlm.nih.gov/PMC8473744
https://doaj.org/article/deff35c63bd84dc1a2ce5b60cb2760ad
Volume 12
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