The Role of Aldosterone in OSA and OSA-Related Hypertension
Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin–angiotensin–aldosterone system activation, etc. Clinical studies have found that there is a high coexistence o...
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| Published in | Frontiers in endocrinology (Lausanne) Vol. 12; p. 801689 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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12.01.2022
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| Abstract | Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin–angiotensin–aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension. |
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| AbstractList | Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin-angiotensin-aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension. Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin-angiotensin-aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension.Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin-angiotensin-aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension. |
| Author | Wang, Yi Lu, Fang Ying Li, Ning Li, Qing Yun Li, Shi Qi Li, Chuan Xiang Zhang, Liu Yan, Ya Ru Lin, Ying Ni Zhang, Li Yue |
| AuthorAffiliation | 2 Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai , China 1 Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China 3 Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Ruijin Hospital , Shanghai , China 4 Department of Respiratory and Critical Care Medicine, Tongren Hospital Affiliated to Wuhan University, The Third Hospital of Wuhan , Wuhan , China |
| AuthorAffiliation_xml | – name: 2 Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai , China – name: 1 Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China – name: 4 Department of Respiratory and Critical Care Medicine, Tongren Hospital Affiliated to Wuhan University, The Third Hospital of Wuhan , Wuhan , China – name: 3 Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Ruijin Hospital , Shanghai , China |
| Author_xml | – sequence: 1 givenname: Yi surname: Wang fullname: Wang, Yi – sequence: 2 givenname: Chuan Xiang surname: Li fullname: Li, Chuan Xiang – sequence: 3 givenname: Ying Ni surname: Lin fullname: Lin, Ying Ni – sequence: 4 givenname: Li Yue surname: Zhang fullname: Zhang, Li Yue – sequence: 5 givenname: Shi Qi surname: Li fullname: Li, Shi Qi – sequence: 6 givenname: Liu surname: Zhang fullname: Zhang, Liu – sequence: 7 givenname: Ya Ru surname: Yan fullname: Yan, Ya Ru – sequence: 8 givenname: Fang Ying surname: Lu fullname: Lu, Fang Ying – sequence: 9 givenname: Ning surname: Li fullname: Li, Ning – sequence: 10 givenname: Qing Yun surname: Li fullname: Li, Qing Yun |
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| Copyright | Copyright © 2022 Wang, Li, Lin, Zhang, Li, Zhang, Yan, Lu, Li and Li. Copyright © 2022 Wang, Li, Lin, Zhang, Li, Zhang, Yan, Lu, Li and Li 2022 Wang, Li, Lin, Zhang, Li, Zhang, Yan, Lu, Li and Li |
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| Keywords | obstructive sleep apnea mineralocorticoid receptor antagonists continuous positive airway pressure (CPAP) hypertension aldosterone |
| Language | English |
| License | Copyright © 2022 Wang, Li, Lin, Zhang, Li, Zhang, Yan, Lu, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| SubjectTerms | aldosterone Aldosterone - metabolism Continuous Positive Airway Pressure continuous positive airway pressure (CPAP) Endocrinology Humans Hyperaldosteronism - epidemiology Hyperaldosteronism - metabolism Hyperaldosteronism - physiopathology hypertension Hypertension - epidemiology Hypertension - metabolism Hypertension - physiopathology mineralocorticoid receptor antagonists obstructive sleep apnea Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - metabolism Sleep Apnea, Obstructive - physiopathology Sleep Apnea, Obstructive - therapy |
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| Title | The Role of Aldosterone in OSA and OSA-Related Hypertension |
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