Macrophage Polarization and Its Role in Liver Disease

• Published in: Frontiers in immunology Vol. 12; p. 803037
• Main Authors: Wang, Cheng, Ma, Cheng, Gong, Lihong, Guo, Yuqin, Fu, Ke, Zhang, Yafang, Zhou, Honglin, Li, Yunxia
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.12.2021
• Subjects: acute liver injury; alcoholic liver disease; Animals; Biomarkers; Cell Differentiation; Cell Plasticity - genetics; Cell Plasticity - immunology; Diagnosis, Differential; Disease Susceptibility - immunology; Energy Metabolism; Gene Expression Regulation; Humans; Immunology; liver disease; Liver Diseases - diagnosis; Liver Diseases - etiology; Liver Diseases - metabolism; Liver Diseases - therapy; Macrophage Activation - genetics; Macrophage Activation - immunology; macrophage polarization; Macrophages - immunology; Macrophages - metabolism; Macrophages - pathology; metabolic-associated fatty liver disease; Organ Specificity - genetics; Organ Specificity - immunology; Phenotype; Signal Transduction; viral hepatitis; viral hepatitis; alcoholic liver disease; liver fibrosis; liver disease; macrophage polarization; metabolic-associated fatty liver disease; hepatocellular carcinoma; acute liver injury

Macrophages are important immune cells in innate immunity, and have remarkable heterogeneity and polarization. Under pathological conditions, in addition to the resident macrophages, other macrophages are also recruited to the diseased tissues, and polarize to various phenotypes (mainly M1 and M2) u...