The missing indicator approach for censored covariates subject to limit of detection in logistic regression models

• Published in: Annals of epidemiology Vol. 38; pp. 57 - 64
• Main Authors: Chiou, Sy Han, Betensky, Rebecca A., Balasubramanian, Raji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019
• Subjects: Bias; Case-Control Studies; Data Interpretation, Statistical; Humans; Limit of Detection; Logistic Models; Logistics regression; Matched design; Metabolome; Metabolomics; Models, Statistical; Tandem Mass Spectrometry; Limit of detection; Metabolomics; Logistics regression; Matched design

In several biomedical studies, one or more exposures of interest may be subject to nonrandom missingness because of the failure of the measurement assay at levels below its limit of detection. This issue is commonly encountered in studies of the metabolome using tandem mass spectrometry–based techno...