PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action

• Published in: Frontiers in endocrinology (Lausanne) Vol. 12; p. 624112
• Main Authors: Hernandez-Quiles, Miguel, Broekema, Marjoleine F., Kalkhoven, Eric
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.02.2021
• Subjects: adipocyte; Adipocytes - metabolism; Animals; cancer cell; Endocrinology; Energy Metabolism - physiology; Humans; immune cell; Immune System - metabolism; mechanism; Neoplasms - metabolism; PPAR gamma - metabolism; PPARy; immune cell; cancer cell; PPARy; mechanism; adipocyte

The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, is one of the most extensively studied ligand-inducible transcription factors. Since its identification in the early 1990s, PPARγ is best known for its critical role in adipocyte differentiation, maintenance...