Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation

Reactivation of latent human cytomegalovirus (HCMV) following allogeneic transplantation is a major cause of morbidity and mortality and predisposes to severe complications, including superinfection by Aspergillus species (spp). Antimicrobial polypeptides, including defensins and mannan-binding lect...

Full description

Saved in:
Bibliographic Details
Published inBlood Vol. 108; no. 10; pp. 3387 - 3396
Main Authors Bozza, Silvia, Bistoni, Francesco, Gaziano, Roberta, Pitzurra, Lucia, Zelante, Teresa, Bonifazi, Pierluigi, Perruccio, Katia, Bellocchio, Silvia, Neri, Mariella, Iorio, Anna Maria, Salvatori, Giovanni, De Santis, Rita, Calvitti, Mario, Doni, Andrea, Garlanda, Cecilia, Mantovani, Alberto, Romani, Luigina
Format Journal Article
LanguageEnglish
Published Washington, DC Elsevier Inc 15.11.2006
The Americain Society of Hematology
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
C-Reactive Protein - immunology
C-Reactive Protein - physiology
Cytomegalovirus - metabolism
Cytomegalovirus - pathogenicity
Dendritic Cells
Herpesviridae Infections
Human viral diseases
Infectious diseases
Interferon Regulatory Factor-3 - metabolism
Interferon-gamma
Interleukin-12
Medical sciences
Mice
Mice, Knockout
Muromegalovirus - metabolism
Muromegalovirus - pathogenicity
Myeloid Differentiation Factor 88
Nerve Tissue Proteins - immunology
Nerve Tissue Proteins - physiology
Pharmacology. Drug treatments
Serum Amyloid P-Component - immunology
Serum Amyloid P-Component - physiology
Signal Transduction
Toll-Like Receptor 9 - metabolism
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virus Activation
Murine cytomegalovirus
Herpesviridae
Rodentia
Pentraxine PTX3
Betaherpesvirinae
Biological activity
Toll like receptor 9
Human cytomegalovirus
Fungi
Virus
Infection
Aspergillus
Vertebrata
Mammalia
Mouse
Interferon regulatory factor 3
Animal
Antiviral
Fungi Imperfecti
Thallophyta
Online AccessGet full text

Cover

Abstract Reactivation of latent human cytomegalovirus (HCMV) following allogeneic transplantation is a major cause of morbidity and mortality and predisposes to severe complications, including superinfection by Aspergillus species (spp). Antimicrobial polypeptides, including defensins and mannan-binding lectin, are known to block viral fusion by cross-linking sugars on cell surface. Pentraxin 3 (PTX3), a member of the long pentraxin family, successfully restored antifungal immunity in experimental hematopoietic transplantation. We assessed here whether PTX3 binds HCMV and murine virus (MCMV) and the impact on viral infectivity and superinfection in vivo. We found that PTX3 bound both viruses, reduced viral entry and infectivity in vitro, and protected from MCMV primary infection and reactivation as well as Aspergillus superinfection. This occurred through the activation of interferon (IFN) regulatory factor 3 (IRF3) in dendritic cells via the TLR9/MyD88-independent viral recognition sensing and the promotion of the interleukin-12 (IL-12)/IFN-γ–dependent effector pathway.
AbstractList Reactivation of latent human cytomegalovirus (HCMV) following allogeneic transplantation is a major cause of morbidity and mortality and predisposes to severe complications, including superinfection by Aspergillus species (spp). Antimicrobial polypeptides, including defensins and mannan-binding lectin, are known to block viral fusion by cross-linking sugars on cell surface. Pentraxin 3 (PTX3), a member of the long pentraxin family, successfully restored antifungal immunity in experimental hematopoietic transplantation. We assessed here whether PTX3 binds HCMV and murine virus (MCMV) and the impact on viral infectivity and superinfection in vivo. We found that PTX3 bound both viruses, reduced viral entry and infectivity in vitro, and protected from MCMV primary infection and reactivation as well as Aspergillus superinfection. This occurred through the activation of interferon (IFN) regulatory factor 3 (IRF3) in dendritic cells via the TLR9/MyD88-independent viral recognition sensing and the promotion of the interleukin-12 (IL-12)/IFN-γ–dependent effector pathway.
Reactivation of latent human cytomegalovirus (HCMV) following allogeneic transplantation is a major cause of morbidity and mortality and predisposes to severe complications, including superinfection by Aspergillus species (spp). Antimicrobial polypeptides, including defensins and mannan-binding lectin, are known to block viral fusion by cross-linking sugars on cell surface. Pentraxin 3 (PTX3), a member of the long pentraxin family, successfully restored antifungal immunity in experimental hematopoietic transplantation. We assessed here whether PTX3 binds HCMV and murine virus (MCMV) and the impact on viral infectivity and superinfection in vivo. We found that PTX3 bound both viruses, reduced viral entry and infectivity in vitro, and protected from MCMV primary infection and reactivation as well as Aspergillus superinfection. This occurred through the activation of interferon (IFN) regulatory factor 3 (IRF3) in dendritic cells via the TLR9/MyD88-independent viral recognition sensing and the promotion of the interleukin-12 (IL-12)/IFN-gamma-dependent effector pathway.
Abstract Reactivation of latent human cytomegalovirus (HCMV) following allogeneic transplantation is a major cause of morbidity and mortality and predisposes to severe complications, including superinfection by Aspergillus species (spp). Antimicrobial polypeptides, including defensins and mannan-binding lectin, are known to block viral fusion by cross-linking sugars on cell surface. Pentraxin 3 (PTX3), a member of the long pentraxin family, successfully restored antifungal immunity in experimental hematopoietic transplantation. We assessed here whether PTX3 binds HCMV and murine virus (MCMV) and the impact on viral infectivity and superinfection in vivo. We found that PTX3 bound both viruses, reduced viral entry and infectivity in vitro, and protected from MCMV primary infection and reactivation as well as Aspergillus superinfection. This occurred through the activation of interferon (IFN) regulatory factor 3 (IRF3) in dendritic cells via the TLR9/MyD88-independent viral recognition sensing and the promotion of the interleukin-12 (IL-12)/IFN-γ–dependent effector pathway.
Author Iorio, Anna Maria
Calvitti, Mario
Romani, Luigina
Perruccio, Katia
Gaziano, Roberta
Mantovani, Alberto
Salvatori, Giovanni
Doni, Andrea
Bozza, Silvia
Bistoni, Francesco
Bonifazi, Pierluigi
De Santis, Rita
Neri, Mariella
Zelante, Teresa
Pitzurra, Lucia
Bellocchio, Silvia
Garlanda, Cecilia
Author_xml – sequence: 1
  givenname: Silvia
  surname: Bozza
  fullname: Bozza, Silvia
– sequence: 2
  givenname: Francesco
  surname: Bistoni
  fullname: Bistoni, Francesco
– sequence: 3
  givenname: Roberta
  surname: Gaziano
  fullname: Gaziano, Roberta
– sequence: 4
  givenname: Lucia
  surname: Pitzurra
  fullname: Pitzurra, Lucia
– sequence: 5
  givenname: Teresa
  surname: Zelante
  fullname: Zelante, Teresa
– sequence: 6
  givenname: Pierluigi
  surname: Bonifazi
  fullname: Bonifazi, Pierluigi
– sequence: 7
  givenname: Katia
  surname: Perruccio
  fullname: Perruccio, Katia
– sequence: 8
  givenname: Silvia
  surname: Bellocchio
  fullname: Bellocchio, Silvia
– sequence: 9
  givenname: Mariella
  surname: Neri
  fullname: Neri, Mariella
– sequence: 10
  givenname: Anna Maria
  surname: Iorio
  fullname: Iorio, Anna Maria
– sequence: 11
  givenname: Giovanni
  surname: Salvatori
  fullname: Salvatori, Giovanni
– sequence: 12
  givenname: Rita
  surname: De Santis
  fullname: De Santis, Rita
– sequence: 13
  givenname: Mario
  surname: Calvitti
  fullname: Calvitti, Mario
– sequence: 14
  givenname: Andrea
  surname: Doni
  fullname: Doni, Andrea
– sequence: 15
  givenname: Cecilia
  surname: Garlanda
  fullname: Garlanda, Cecilia
– sequence: 16
  givenname: Alberto
  surname: Mantovani
  fullname: Mantovani, Alberto
– sequence: 17
  givenname: Luigina
  surname: Romani
  fullname: Romani, Luigina
  email: lromani@unipg.it
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18281144$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/16840729$$D View this record in MEDLINE/PubMed
BookMark eNp9kMFu1DAQhi1URLeFN0DIF7gFPHacOBcktGqh0lagqnC1HGfcNcraWztb2rev011pb5ysGX__aOY7IychBiTkPbDPAIp_6ccYh4oz1lRMVIx1vGlekQVIrkrF2QlZsPmz7lo4JWc5_2UMasHlG3IKjapZy7sFuf-FYUrm0Qcq6DbFCe2UqUtxQ6-X13-oD650fAzUhIEmNKV4MC-NaZ3i7m5Nb1c3NGPIPtzRrZnW_8xTpiOaYW5MkV7dXAp6zL0lr50ZM747vOfk9-XF7fJHtfr5_Wr5bVVZKWCqjJCicwp64G0tuRC97I0dwJrO9WiNFBaRi9q1alDQMKs61wCzzlnZCmjEOfm0n1uuut9hnvTGZ4vjaALGXdaNAhCSzWC9B22KOSd0epv8xqQnDUzPqvWLaj2r1kzoveoS-3CYv-s3OBxDB7cF-HgATLZmdMkE6_ORU7xsUNeF-7rnsNh48Jh0th6DxcGn4l4P0f9_k2fc-J-M
CitedBy_id crossref_primary_10_1007_s10753_017_0626_1
crossref_primary_10_1111_j_1600_065X_2008_00719_x
crossref_primary_10_1095_biolreprod_109_079111
crossref_primary_10_1007_s10238_022_00926_w
crossref_primary_10_1016_j_micpath_2015_09_011
crossref_primary_10_1002_biof_21
crossref_primary_10_1016_j_micinf_2007_09_002
crossref_primary_10_1152_ajplung_00490_2006
crossref_primary_10_1016_j_abb_2019_07_013
crossref_primary_10_1089_scd_2015_0074
crossref_primary_10_3389_fimmu_2023_1274634
crossref_primary_10_1371_journal_ppat_1003648
crossref_primary_10_1038_labinvest_2012_92
crossref_primary_10_1016_j_molmed_2016_04_007
crossref_primary_10_1111_j_1399_0039_2011_01645_x
crossref_primary_10_3109_08916934_2011_611549
crossref_primary_10_4049_jimmunol_180_5_3391
crossref_primary_10_1111_tri_12197
crossref_primary_10_1016_j_bbcan_2017_11_004
crossref_primary_10_1016_j_ijmm_2011_04_012
crossref_primary_10_3390_vetsci10030239
crossref_primary_10_1016_j_cytogfr_2019_10_006
crossref_primary_10_1016_j_imbio_2012_07_004
crossref_primary_10_1371_journal_pone_0024371
crossref_primary_10_3390_v4010001
crossref_primary_10_1038_s41584_021_00694_z
crossref_primary_10_1111_imr_12570
crossref_primary_10_1016_j_matbio_2018_01_027
crossref_primary_10_1016_j_imlet_2014_04_012
crossref_primary_10_1016_j_cyto_2016_07_012
crossref_primary_10_1038_s41590_021_01114_w
crossref_primary_10_1111_nyas_12043
crossref_primary_10_1007_s10096_011_1392_x
crossref_primary_10_1007_s10753_014_9921_2
crossref_primary_10_3390_v14010045
crossref_primary_10_1128_IAI_00709_18
crossref_primary_10_18632_oncotarget_13488
crossref_primary_10_1016_j_hrtlng_2012_11_005
crossref_primary_10_3390_ijms241814195
crossref_primary_10_1016_j_jri_2009_05_006
crossref_primary_10_1016_j_vaccine_2016_12_054
crossref_primary_10_1128_JVI_02627_06
crossref_primary_10_1371_journal_pone_0060767
crossref_primary_10_3389_fimmu_2019_00088
crossref_primary_10_1016_j_antiviral_2013_10_001
crossref_primary_10_1172_JCI60862
crossref_primary_10_1007_s12012_021_09671_0
crossref_primary_10_1128_microbiolspec_MCHD_0051_2016
crossref_primary_10_1146_annurev_immunol_030409_101305
crossref_primary_10_1152_physrev_00016_2017
crossref_primary_10_1586_ehm_10_40
crossref_primary_10_1007_s10989_018_9710_0
crossref_primary_10_1177_1753425910391826
crossref_primary_10_4049_jimmunol_1002035
crossref_primary_10_1182_blood_2009_12_258376
crossref_primary_10_1093_cid_civ679
crossref_primary_10_1007_s00441_010_1018_0
crossref_primary_10_1016_j_smim_2013_05_002
crossref_primary_10_4049_jimmunol_180_9_5799
crossref_primary_10_18632_oncotarget_23902
crossref_primary_10_3389_fimmu_2019_00794
crossref_primary_10_1111_2049_632X_12083
crossref_primary_10_1007_s13317_010_0010_8
crossref_primary_10_1093_intimm_dxm119
crossref_primary_10_3389_falgy_2021_678023
crossref_primary_10_1515_jpm_2009_141
crossref_primary_10_1016_j_tim_2015_09_006
crossref_primary_10_1038_mi_2016_52
crossref_primary_10_1007_s10875_007_9126_7
crossref_primary_10_3109_13693786_2011_648215
crossref_primary_10_1056_NEJMoa1211161
crossref_primary_10_1371_journal_ppat_1004649
crossref_primary_10_1007_s00134_010_2067_2
crossref_primary_10_1016_j_vph_2017_10_003
crossref_primary_10_1128_JVI_06143_11
crossref_primary_10_1016_j_smim_2016_10_012
crossref_primary_10_1016_j_dci_2023_105064
crossref_primary_10_1089_vim_2009_0011
crossref_primary_10_1016_j_clim_2012_06_002
crossref_primary_10_4049_jimmunol_1003737
crossref_primary_10_1371_journal_pone_0034965
crossref_primary_10_1002_eji_201545892
crossref_primary_10_4049_jimmunol_1301814
crossref_primary_10_1371_journal_ppat_0030123
crossref_primary_10_14712_18059694_2017_56
crossref_primary_10_4049_jimmunol_1400814
crossref_primary_10_1902_jop_2013_120718
crossref_primary_10_1002_ppul_23199
crossref_primary_10_1002_1873_3468_13744
crossref_primary_10_1097_TP_0b013e31826c39de
crossref_primary_10_1155_2017_1092738
crossref_primary_10_1159_000368778
crossref_primary_10_1371_journal_ppat_1007469
crossref_primary_10_1155_2013_725102
crossref_primary_10_1007_s10753_015_0151_z
crossref_primary_10_1016_j_celrep_2020_108513
crossref_primary_10_1155_2011_830421
crossref_primary_10_1016_j_exer_2016_11_017
crossref_primary_10_1111_imr_12476
crossref_primary_10_1007_s00430_023_00770_z
Cites_doi 10.1128/JVI.77.8.4588-4596.2003
10.1084/jem.20021973
10.1038/ni880
10.1146/annurev.immunol.21.120601.141126
10.1099/0022-1317-83-12-2983
10.1128/JVI.71.1.267-275.1997
10.1038/nri1549
10.1016/j.virol.2006.01.042
10.1016/S1074-7613(01)00154-6
10.1182/blood-2005-06-2416
10.1002/eji.200324390
10.1128/JVI.78.20.10995-11006.2004
10.4049/jimmunol.174.3.1587
10.1126/science.1087262
10.1016/S1286-4579(02)00007-2
10.4049/jimmunol.156.12.4746
10.1182/blood-2005-03-1112
10.1586/14787210.2.4.559
10.1016/j.humimm.2004.02.022
10.1016/j.ccm.2005.06.013
10.1128/JVI.80.2.1032-1037.2006
10.1084/jem.20021522
10.1038/nature01195
10.1016/j.molimm.2004.07.040
10.1128/MCB.18.5.2986
10.4049/jimmunol.156.3.1138
10.1084/jem.20011672
10.1073/pnas.0400525101
10.1128/JVI.66.4.1977-1984.1992
10.1084/jem.169.4.1199
10.1084/jem.182.4.1045
10.1172/JCI21948
10.1016/j.virusres.2003.08.009
10.1182/blood-2005-05-1775
10.1016/j.coi.2004.11.004
10.1146/annurev.immunol.23.021704.115756
10.1002/jmv.20397
10.1016/j.micinf.2003.09.007
10.1128/JVI.72.1.873-875.1998
10.1146/annurev.biochem.69.1.531
10.1038/ni724
10.4049/jimmunol.169.1.359
10.1084/jem.179.1.185
10.1126/science.1060042
10.1038/nri1526
10.1128/IAI.70.5.2375-2382.2002
10.4049/jimmunol.165.9.4787
10.1016/j.immuni.2004.06.007
10.1182/blood-2003-03-0748
10.1128/JVI.61.10.3102-3108.1987
10.1038/ni1248
10.1038/ni1244
10.1128/JVI.67.9.5360-5366.1993
10.1038/ni736
10.1084/jem.188.3.577
10.1016/j.immuni.2005.03.008
10.1038/35093109
10.1046/j.1365-2249.2000.01110.x
10.1016/S1473-3099(04)01202-2
10.1128/JVI.78.3.1202-1211.2004
10.1016/j.tcb.2003.10.009
10.4049/jimmunol.175.12.8303
10.4049/jimmunol.175.10.6723
10.1128/JVI.71.4.2980-2987.1997
10.1084/jem.169.6.2191
ContentType Journal Article
Copyright 2006 American Society of Hematology
2007 INIST-CNRS
Copyright_xml – notice: 2006 American Society of Hematology
– notice: 2007 INIST-CNRS
DBID 6I.
AAFTH
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1182/blood-2006-03-009266
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Biology
Anatomy & Physiology
EISSN 1528-0020
EndPage 3396
ExternalDocumentID 10_1182_blood_2006_03_009266
16840729
18281144
S0006497120523252
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-~X
.55
.GJ
1CY
23N
2WC
34G
39C
4.4
53G
5GY
5RE
5VS
6I.
6J9
9M8
AAEDW
AAFTH
AAXUO
ABOCM
ABVKL
ACGFO
ADBBV
AENEX
AFFNX
AFOSN
AHPSJ
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BTFSW
C1A
CS3
DIK
DU5
E3Z
EBS
EJD
EX3
F5P
FDB
FRP
GS5
GX1
IH2
J5H
K-O
KQ8
L7B
LSO
MJL
N4W
N9A
OK1
P2P
R.V
RHF
RHI
ROL
SJN
THE
TR2
TWZ
W2D
W8F
WH7
WOQ
WOW
X7M
YHG
YKV
ZA5
ZGI
08R
AAQQT
AAUGY
ABPTK
AI.
AMRAJ
H13
IQODW
MVM
OHT
UCJ
VH1
WHG
ZXP
0R~
0SF
AALRI
ADVLN
AITUG
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c531t-a3539f81b12745233b5bacd1ca9fbeca53cee234f78d8160c89f610cffc573163
IEDL.DBID ABVKL
ISSN 0006-4971
IngestDate Sat Aug 17 02:25:54 EDT 2024
Fri Aug 23 03:34:27 EDT 2024
Sat Sep 28 08:40:12 EDT 2024
Sun Oct 22 16:08:37 EDT 2023
Fri Feb 23 02:45:07 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Keywords Murine cytomegalovirus
Herpesviridae
Rodentia
Pentraxine PTX3
Betaherpesvirinae
Biological activity
Toll like receptor 9
Human cytomegalovirus
Fungi
Virus
Infection
Aspergillus
Vertebrata
Mammalia
Mouse
Interferon regulatory factor 3
Animal
Antiviral
Fungi Imperfecti
Thallophyta
Language English
License This article is made available under the Elsevier license.
CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c531t-a3539f81b12745233b5bacd1ca9fbeca53cee234f78d8160c89f610cffc573163
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.sciencedirect.com/science/article/pii/S0006497120523252
PMID 16840729
PQID 68113506
PQPubID 23479
PageCount 10
ParticipantIDs proquest_miscellaneous_68113506
crossref_primary_10_1182_blood_2006_03_009266
pubmed_primary_16840729
pascalfrancis_primary_18281144
elsevier_sciencedirect_doi_10_1182_blood_2006_03_009266
PublicationCentury 2000
PublicationDate 2006-11-15
PublicationDateYYYYMMDD 2006-11-15
PublicationDate_xml – month: 11
  year: 2006
  text: 2006-11-15
  day: 15
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Blood
PublicationTitleAlternate Blood
PublicationYear 2006
Publisher Elsevier Inc
The Americain Society of Hematology
Publisher_xml – name: Elsevier Inc
– name: The Americain Society of Hematology
References Chang, Vargas, DelPortillo, Klotman (bib29) 2005; 115
Ison, Fishman (bib45) 2005; 26
Krug, French, Barchet (bib10) 2004; 21
Orange, Wang, Terhorst, Biron (bib17) 1995; 182
Lodoen, Ogasawara, Hamerman (bib59) 2003; 197
Peggs (bib3) 2004; 2
Orange, Biron (bib21) 1996; 156
Brown, Dokun, Heusel (bib36) 2001; 292
Garlanda, Bottazzi, Bastone, Mantovani (bib24) 2005; 23
Boehme, Singh, Perry, Compton (bib13) 2004; 78
Degli-Esposti, Smyth (bib8) 2005; 5
Gribaudo, Riera, Rudge, Caposio, Johnson, Landolfo (bib31) 2002; 83
Pien, Satoskar, Takeda, Akira, Biron (bib22) 2000; 165
Lin, Heylbroeck, Pitha, Hiscott (bib40) 1998; 18
Reddehase, Balthesen, Rapp, Jonjic, Pavic, Koszinowski (bib56) 1994; 179
Moss, Rickinson (bib4) 2005; 5
Lucin, Pavic, Polic, Jonjic, Koszinowski (bib65) 1992; 66
Luchetti, Piccinini, Mantovani (bib37) 2000; 119
Compton (bib30) 2004; 14
Vliegen, Herngreen, Grauls, Bruggeman, Stassen (bib41) 2003; 98
Gandhi, Khanna (bib1) 2004; 4
Saito, Servenius, Compton, Fox (bib62) 1989; 169
Cenci, Mencacci, Spreca (bib38) 2002; 70
Andrews, Andoniou, Granucci, Ricciardi-Castagnoli, Degli-Esposti (bib14) 2001; 2
Abate, Watanabe, Mocarski (bib43) 2004; 78
Takeda, Kaisho, Akira (bib50) 2003; 21
Diefenbach, Jensen, Jamieson, Raulet (bib58) 2001; 413
Andrews, Scalzo, Yokoyama, Smyth, Degli-Esposti (bib47) 2003; 4
Beutler, Crozat, Koziol, Georgel (bib7) 2005; 17
Dalod, Hamilton, Salomon (bib15) 2003; 197
Doni, Peri, Chieppa (bib25) 2003; 33
Wilkin, Feinberg (bib46) 2000; 14
Gosselin, Borgeat, Flamand (bib34) 2005; 174
Goriely, Molle, Nguyen (bib44) 2006; 107
Orange, Biron (bib18) 1996; 156
Garlanda, Hirsch, Bozza (bib26) 2002; 420
Leikina, Delanoe-Ayari, Melikov (bib28) 2005; 6
Jeannin, Bottazzi, Sironi (bib51) 2005; 22
Asselin-Paturel, Boonstra, Dalod (bib19) 2001; 2
Hebart, Einsele (bib2) 2004; 65
Jonjic, Mutter, Weiland, Reddehase, Koszinowski (bib49) 1989; 169
Zannetti, Mondini, De Andrea (bib32) 2006; 349
Perruccio, Tosti, Burchielli (bib5) 2005; 106
Baruah, Propato, Dumitriu (bib54) 2006; 107
DeFilippis, Robinson, Keck, Hansen, Nelson, Fruh (bib12) 2006; 80
Andoniou, van Dommelen, Voigt (bib20) 2005; 6
Tabeta, Georgel, Janssen (bib11) 2004; 101
Mairuhu, Peri, Setiati (bib27) 2005; 76
Kurz, Steffens, Mayer, Harris, Reddehase (bib35) 1997; 71
Turner, Bruun, Minson, Browne (bib52) 1998; 72
Tay, Welsh (bib23) 1997; 71
Presti, Pollock, Dal Canto, O'Guin, Virgin (bib66) 1998; 188
Andrews, Andoniou, Scalzo (bib48) 2005; 42
Biron (bib6) 2001; 14
Bozza, Gaziano, Lipford (bib42) 2002; 4
Skehel, Wiley (bib53) 2000; 69
Reddehase, Mutter, Munch, Buhring, Koszinowski (bib64) 1987; 61
Yamamoto, Sato, Hemmi (bib61) 2003; 301
Krmpotic, Bubic, Polic, Lucin, Jonjic (bib63) 2003; 5
Gold, Munks, Wagner, Koszinowski, Hill, Fling (bib39) 2002; 169
Han, Mura, Andrade (bib57) 2005; 175
Delale, Paquin, Asselin-Paturel (bib9) 2005; 175
Balthesen, Messerle, Reddehase (bib55) 1993; 67
Compton, Kurt-Jones, Boehme (bib60) 2003; 77
Dalod, Salazar-Mather, Malmgaard (bib16) 2002; 195
Bozza, Perruccio, Montagnoli (bib33) 2003; 102
2019111714431152200_REF38
2019111714431152200_REF39
2019111714431152200_REF40
2019111714431152200_REF41
2019111714431152200_REF42
2019111714431152200_REF43
2019111714431152200_REF44
2019111714431152200_REF45
2019111714431152200_REF46
2019111714431152200_REF47
2019111714431152200_REF48
2019111714431152200_REF27
2019111714431152200_REF28
2019111714431152200_REF29
2019111714431152200_REF30
2019111714431152200_REF31
2019111714431152200_REF32
2019111714431152200_REF33
2019111714431152200_REF34
2019111714431152200_REF35
2019111714431152200_REF36
2019111714431152200_REF37
2019111714431152200_REF16
2019111714431152200_REF17
2019111714431152200_REF18
2019111714431152200_REF19
2019111714431152200_REF60
2019111714431152200_REF61
2019111714431152200_REF62
2019111714431152200_REF63
2019111714431152200_REF20
2019111714431152200_REF64
2019111714431152200_REF21
2019111714431152200_REF65
2019111714431152200_REF22
2019111714431152200_REF66
2019111714431152200_REF23
2019111714431152200_REF24
2019111714431152200_REF25
2019111714431152200_REF26
2019111714431152200_REF49
2019111714431152200_REF1
2019111714431152200_REF2
2019111714431152200_REF3
2019111714431152200_REF4
2019111714431152200_REF5
2019111714431152200_REF6
2019111714431152200_REF7
2019111714431152200_REF8
2019111714431152200_REF9
2019111714431152200_REF50
2019111714431152200_REF51
2019111714431152200_REF52
2019111714431152200_REF53
2019111714431152200_REF10
2019111714431152200_REF54
2019111714431152200_REF11
2019111714431152200_REF55
2019111714431152200_REF12
2019111714431152200_REF56
2019111714431152200_REF13
2019111714431152200_REF57
2019111714431152200_REF14
2019111714431152200_REF58
2019111714431152200_REF15
2019111714431152200_REF59
References_xml – volume: 61
  start-page: 3102
  year: 1987
  end-page: 3108
  ident: bib64
  article-title: CD8-positive T lymphocytes specific for murine cytomegalovirus immediateearly antigens mediate protective immunity.
  publication-title: J Virol
  contributor:
    fullname: Koszinowski
– volume: 14
  start-page: 5
  year: 2004
  end-page: 8
  ident: bib30
  article-title: Receptors and immune sensors: the complex entry path of human cytomegalovirus.
  publication-title: Trends Cell Biol
  contributor:
    fullname: Compton
– volume: 18
  start-page: 2986
  year: 1998
  end-page: 2996
  ident: bib40
  article-title: Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.
  publication-title: Mol Cell Biol
  contributor:
    fullname: Hiscott
– volume: 349
  start-page: 79
  year: 2006
  end-page: 86
  ident: bib32
  article-title: The expression of p16(INK4a) tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication.
  publication-title: Virology
  contributor:
    fullname: De Andrea
– volume: 2
  start-page: 559
  year: 2004
  end-page: 573
  ident: bib3
  article-title: Cytomegalovirus following stem cell transplantation: from pharmacologic to immunologic therapy.
  publication-title: Expert Rev Anti Infect Ther
  contributor:
    fullname: Peggs
– volume: 188
  start-page: 577
  year: 1998
  end-page: 588
  ident: bib66
  article-title: Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels.
  publication-title: J Exp Med
  contributor:
    fullname: Virgin
– volume: 66
  start-page: 1977
  year: 1992
  end-page: 1984
  ident: bib65
  article-title: Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands.
  publication-title: J Virol
  contributor:
    fullname: Koszinowski
– volume: 23
  start-page: 337
  year: 2005
  end-page: 366
  ident: bib24
  article-title: Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
  publication-title: Annu Rev Immunol
  contributor:
    fullname: Mantovani
– volume: 182
  start-page: 1045
  year: 1995
  end-page: 1056
  ident: bib17
  article-title: Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.
  publication-title: J Exp Med
  contributor:
    fullname: Biron
– volume: 26
  start-page: 691
  year: 2005
  end-page: 705
  ident: bib45
  article-title: Cytomegalovirus pneumonia in transplant recipients.
  publication-title: Clin Chest Med
  contributor:
    fullname: Fishman
– volume: 98
  start-page: 17
  year: 2003
  end-page: 25
  ident: bib41
  article-title: Improved detection and quantification of mouse cytomegalovirus by real-time PCR.
  publication-title: Virus Res
  contributor:
    fullname: Stassen
– volume: 5
  start-page: 9
  year: 2005
  end-page: 20
  ident: bib4
  article-title: Cellular immunotherapy for viral infection after HSC transplantation.
  publication-title: Nat Rev Immunol
  contributor:
    fullname: Rickinson
– volume: 14
  start-page: 661
  year: 2001
  end-page: 664
  ident: bib6
  article-title: Interferons alpha and beta as immune regulators-a new look.
  publication-title: Immunity
  contributor:
    fullname: Biron
– volume: 78
  start-page: 1202
  year: 2004
  end-page: 1211
  ident: bib13
  article-title: Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B.
  publication-title: J Virol
  contributor:
    fullname: Compton
– volume: 174
  start-page: 1587
  year: 2005
  end-page: 1593
  ident: bib34
  article-title: Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation.
  publication-title: J Immunol
  contributor:
    fullname: Flamand
– volume: 175
  start-page: 6723
  year: 2005
  end-page: 6732
  ident: bib9
  article-title: MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
  publication-title: J Immunol
  contributor:
    fullname: Asselin-Paturel
– volume: 119
  start-page: 196
  year: 2000
  end-page: 202
  ident: bib37
  article-title: Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA).
  publication-title: Clin Exp Immunol
  contributor:
    fullname: Mantovani
– volume: 169
  start-page: 2191
  year: 1989
  end-page: 2198
  ident: bib62
  article-title: Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome.
  publication-title: J Exp Med
  contributor:
    fullname: Fox
– volume: 5
  start-page: 1263
  year: 2003
  end-page: 1277
  ident: bib63
  article-title: Pathogenesis of murine cytomegalovirus infection.
  publication-title: Microbes Infect
  contributor:
    fullname: Jonjic
– volume: 195
  start-page: 517
  year: 2002
  end-page: 528
  ident: bib16
  article-title: Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo.
  publication-title: J Exp Med
  contributor:
    fullname: Malmgaard
– volume: 71
  start-page: 267
  year: 1997
  end-page: 275
  ident: bib23
  article-title: Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells.
  publication-title: J Virol
  contributor:
    fullname: Welsh
– volume: 156
  start-page: 4746
  year: 1996
  end-page: 4756
  ident: bib18
  article-title: Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.
  publication-title: J Immunol
  contributor:
    fullname: Biron
– volume: 2
  start-page: 1077
  year: 2001
  end-page: 1084
  ident: bib14
  article-title: Infection of dendritic cells by murine cytomegalovirus induces functional paralysis.
  publication-title: Nat Immunol
  contributor:
    fullname: Degli-Esposti
– volume: 67
  start-page: 5360
  year: 1993
  end-page: 5366
  ident: bib55
  article-title: Lungs are a major organ site of cytomegalovirus latency and recurrence.
  publication-title: J Virol
  contributor:
    fullname: Reddehase
– volume: 2
  start-page: 1144
  year: 2001
  end-page: 1150
  ident: bib19
  article-title: Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology.
  publication-title: Nat Immunol
  contributor:
    fullname: Dalod
– volume: 76
  start-page: 547
  year: 2005
  end-page: 552
  ident: bib27
  article-title: Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections.
  publication-title: J Med Virol
  contributor:
    fullname: Setiati
– volume: 14
  start-page: 1701
  year: 2000
  end-page: 1708
  ident: bib46
  article-title: Prophylaxis against fungal infections and cytomegalovirus disease after bone marrow transplantation.
  publication-title: Oncology (Williston Park)
  contributor:
    fullname: Feinberg
– volume: 6
  start-page: 995
  year: 2005
  end-page: 1001
  ident: bib28
  article-title: Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins.
  publication-title: Nat Immunol
  contributor:
    fullname: Melikov
– volume: 413
  start-page: 165
  year: 2001
  end-page: 171
  ident: bib58
  article-title: Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity.
  publication-title: Nature
  contributor:
    fullname: Raulet
– volume: 107
  start-page: 1078
  year: 2006
  end-page: 1084
  ident: bib44
  article-title: Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.
  publication-title: Blood
  contributor:
    fullname: Nguyen
– volume: 72
  start-page: 873
  year: 1998
  end-page: 875
  ident: bib52
  article-title: Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system.
  publication-title: J Virol
  contributor:
    fullname: Browne
– volume: 107
  start-page: 151
  year: 2006
  end-page: 158
  ident: bib54
  article-title: The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens.
  publication-title: Blood
  contributor:
    fullname: Dumitriu
– volume: 106
  start-page: 4397
  year: 2005
  end-page: 4406
  ident: bib5
  article-title: Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation.
  publication-title: Blood
  contributor:
    fullname: Burchielli
– volume: 5
  start-page: 112
  year: 2005
  end-page: 124
  ident: bib8
  article-title: Close encounters of different kinds: dendritic cells and NK cells take centre stage.
  publication-title: Nat Rev Immunol
  contributor:
    fullname: Smyth
– volume: 197
  start-page: 885
  year: 2003
  end-page: 898
  ident: bib15
  article-title: Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta.
  publication-title: J Exp Med
  contributor:
    fullname: Salomon
– volume: 65
  start-page: 432
  year: 2004
  end-page: 436
  ident: bib2
  article-title: Clinical aspects of CMV fectionin after stem cell transplantation.
  publication-title: Hum Immunol
  contributor:
    fullname: Einsele
– volume: 6
  start-page: 1011
  year: 2005
  end-page: 1019
  ident: bib20
  article-title: Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.
  publication-title: Nat Immunol
  contributor:
    fullname: Voigt
– volume: 4
  start-page: 175
  year: 2003
  end-page: 181
  ident: bib47
  article-title: Functional interactions between dendritic cells and NK cells during viral infection.
  publication-title: Nat Immunol
  contributor:
    fullname: Degli-Esposti
– volume: 197
  start-page: 1245
  year: 2003
  end-page: 1253
  ident: bib59
  article-title: NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.
  publication-title: J Exp Med
  contributor:
    fullname: Hamerman
– volume: 69
  start-page: 531
  year: 2000
  end-page: 569
  ident: bib53
  article-title: Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.
  publication-title: Annu Rev Biochem
  contributor:
    fullname: Wiley
– volume: 115
  start-page: 765
  year: 2005
  end-page: 773
  ident: bib29
  article-title: Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity.
  publication-title: J Clin Invest
  contributor:
    fullname: Klotman
– volume: 101
  start-page: 3516
  year: 2004
  end-page: 3521
  ident: bib11
  article-title: Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Janssen
– volume: 169
  start-page: 359
  year: 2002
  end-page: 365
  ident: bib39
  article-title: The murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL but does not alter the immunodominance of the M45-specific CD8 T cell response in vivo.
  publication-title: J Immunol
  contributor:
    fullname: Fling
– volume: 420
  start-page: 182
  year: 2002
  end-page: 186
  ident: bib26
  article-title: Nonredundant role of the long pentraxin PTX3 in anti-fungal innate immune response.
  publication-title: Nature
  contributor:
    fullname: Bozza
– volume: 301
  start-page: 640
  year: 2003
  end-page: 643
  ident: bib61
  article-title: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
  publication-title: Science
  contributor:
    fullname: Hemmi
– volume: 83
  start-page: 2983
  year: 2002
  end-page: 2993
  ident: bib31
  article-title: Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts.
  publication-title: J Gen Virol
  contributor:
    fullname: Landolfo
– volume: 179
  start-page: 185
  year: 1994
  end-page: 193
  ident: bib56
  article-title: The conditions of primary infection define the load of latent viral genome in organs and the risk of recurrent cytomegalovirus disease.
  publication-title: J Exp Med
  contributor:
    fullname: Koszinowski
– volume: 78
  start-page: 10995
  year: 2004
  end-page: 11006
  ident: bib43
  article-title: Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response.
  publication-title: J Virol
  contributor:
    fullname: Mocarski
– volume: 102
  start-page: 3807
  year: 2003
  end-page: 3814
  ident: bib33
  article-title: A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation.
  publication-title: Blood
  contributor:
    fullname: Montagnoli
– volume: 70
  start-page: 2375
  year: 2002
  end-page: 2382
  ident: bib38
  article-title: Protection of killer antiidiotypic antibodies against early invasive aspergillosis in a murine model of allogeneic T-cell-depleted bone marrow transplantation.
  publication-title: Infect Immun
  contributor:
    fullname: Spreca
– volume: 71
  start-page: 2980
  year: 1997
  end-page: 2987
  ident: bib35
  article-title: Latency versus persistence or intermittent recurrences: evidence for a latent state of murine cytomegalovirus in the lungs.
  publication-title: J Virol
  contributor:
    fullname: Reddehase
– volume: 165
  start-page: 4787
  year: 2000
  end-page: 4791
  ident: bib22
  article-title: Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection.
  publication-title: J Immunol
  contributor:
    fullname: Biron
– volume: 80
  start-page: 1032
  year: 2006
  end-page: 1037
  ident: bib12
  article-title: Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection.
  publication-title: J Virol
  contributor:
    fullname: Fruh
– volume: 22
  start-page: 551
  year: 2005
  end-page: 560
  ident: bib51
  article-title: Complexity and complementarity of outer membrane protein: a recognition by cellular and humoral innate immunity receptors.
  publication-title: Immunity
  contributor:
    fullname: Sironi
– volume: 169
  start-page: 1199
  year: 1989
  end-page: 1212
  ident: bib49
  article-title: Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
  publication-title: J Exp Med
  contributor:
    fullname: Koszinowski
– volume: 21
  start-page: 335
  year: 2003
  end-page: 376
  ident: bib50
  article-title: Toll-like receptors.
  publication-title: Annu Rev Immunol
  contributor:
    fullname: Akira
– volume: 292
  start-page: 934
  year: 2001
  end-page: 937
  ident: bib36
  article-title: Vital involvement of a natural killer cell activation receptor in resistance to viral infection.
  publication-title: Science
  contributor:
    fullname: Heusel
– volume: 77
  start-page: 4588
  year: 2003
  end-page: 4596
  ident: bib60
  article-title: Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
  publication-title: J Virol
  contributor:
    fullname: Boehme
– volume: 42
  start-page: 547
  year: 2005
  end-page: 555
  ident: bib48
  article-title: Cross-talk between dendritic cells and natural killer cells in viral infection.
  publication-title: Mol Immunol
  contributor:
    fullname: Scalzo
– volume: 4
  start-page: 725
  year: 2004
  end-page: 738
  ident: bib1
  article-title: Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments.
  publication-title: Lancet Infect Dis
  contributor:
    fullname: Khanna
– volume: 156
  start-page: 1138
  year: 1996
  end-page: 1142
  ident: bib21
  article-title: An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense: studies of natural killer and T cell responses in contrasting viral infections.
  publication-title: J Immunol
  contributor:
    fullname: Biron
– volume: 4
  start-page: 1281
  year: 2002
  end-page: 1290
  ident: bib42
  article-title: Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants.
  publication-title: Microbes Infect
  contributor:
    fullname: Lipford
– volume: 33
  start-page: 2886
  year: 2003
  end-page: 2893
  ident: bib25
  article-title: Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells.
  publication-title: Eur J Immunol
  contributor:
    fullname: Chieppa
– volume: 21
  start-page: 107
  year: 2004
  end-page: 119
  ident: bib10
  article-title: TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.
  publication-title: Immunity
  contributor:
    fullname: Barchet
– volume: 17
  start-page: 36
  year: 2005
  end-page: 43
  ident: bib7
  article-title: Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model.
  publication-title: Curr Opin Immunol
  contributor:
    fullname: Georgel
– volume: 175
  start-page: 8303
  year: 2005
  end-page: 8311
  ident: bib57
  article-title: TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK.
  publication-title: J Immunol
  contributor:
    fullname: Andrade
– ident: 2019111714431152200_REF60
  doi: 10.1128/JVI.77.8.4588-4596.2003
– ident: 2019111714431152200_REF59
  doi: 10.1084/jem.20021973
– ident: 2019111714431152200_REF47
  doi: 10.1038/ni880
– ident: 2019111714431152200_REF50
  doi: 10.1146/annurev.immunol.21.120601.141126
– ident: 2019111714431152200_REF31
  doi: 10.1099/0022-1317-83-12-2983
– ident: 2019111714431152200_REF23
  doi: 10.1128/JVI.71.1.267-275.1997
– ident: 2019111714431152200_REF8
  doi: 10.1038/nri1549
– ident: 2019111714431152200_REF46
– ident: 2019111714431152200_REF32
  doi: 10.1016/j.virol.2006.01.042
– ident: 2019111714431152200_REF6
  doi: 10.1016/S1074-7613(01)00154-6
– ident: 2019111714431152200_REF44
  doi: 10.1182/blood-2005-06-2416
– ident: 2019111714431152200_REF25
  doi: 10.1002/eji.200324390
– ident: 2019111714431152200_REF43
  doi: 10.1128/JVI.78.20.10995-11006.2004
– ident: 2019111714431152200_REF34
  doi: 10.4049/jimmunol.174.3.1587
– ident: 2019111714431152200_REF61
  doi: 10.1126/science.1087262
– ident: 2019111714431152200_REF42
  doi: 10.1016/S1286-4579(02)00007-2
– ident: 2019111714431152200_REF18
  doi: 10.4049/jimmunol.156.12.4746
– ident: 2019111714431152200_REF54
  doi: 10.1182/blood-2005-03-1112
– ident: 2019111714431152200_REF3
  doi: 10.1586/14787210.2.4.559
– ident: 2019111714431152200_REF2
  doi: 10.1016/j.humimm.2004.02.022
– ident: 2019111714431152200_REF45
  doi: 10.1016/j.ccm.2005.06.013
– ident: 2019111714431152200_REF12
  doi: 10.1128/JVI.80.2.1032-1037.2006
– ident: 2019111714431152200_REF15
  doi: 10.1084/jem.20021522
– ident: 2019111714431152200_REF26
  doi: 10.1038/nature01195
– ident: 2019111714431152200_REF48
  doi: 10.1016/j.molimm.2004.07.040
– ident: 2019111714431152200_REF40
  doi: 10.1128/MCB.18.5.2986
– ident: 2019111714431152200_REF21
  doi: 10.4049/jimmunol.156.3.1138
– ident: 2019111714431152200_REF16
  doi: 10.1084/jem.20011672
– ident: 2019111714431152200_REF11
  doi: 10.1073/pnas.0400525101
– ident: 2019111714431152200_REF65
  doi: 10.1128/JVI.66.4.1977-1984.1992
– ident: 2019111714431152200_REF49
  doi: 10.1084/jem.169.4.1199
– ident: 2019111714431152200_REF17
  doi: 10.1084/jem.182.4.1045
– ident: 2019111714431152200_REF29
  doi: 10.1172/JCI21948
– ident: 2019111714431152200_REF41
  doi: 10.1016/j.virusres.2003.08.009
– ident: 2019111714431152200_REF5
  doi: 10.1182/blood-2005-05-1775
– ident: 2019111714431152200_REF7
  doi: 10.1016/j.coi.2004.11.004
– ident: 2019111714431152200_REF24
  doi: 10.1146/annurev.immunol.23.021704.115756
– ident: 2019111714431152200_REF27
  doi: 10.1002/jmv.20397
– ident: 2019111714431152200_REF63
  doi: 10.1016/j.micinf.2003.09.007
– ident: 2019111714431152200_REF52
  doi: 10.1128/JVI.72.1.873-875.1998
– ident: 2019111714431152200_REF53
  doi: 10.1146/annurev.biochem.69.1.531
– ident: 2019111714431152200_REF14
  doi: 10.1038/ni724
– ident: 2019111714431152200_REF39
  doi: 10.4049/jimmunol.169.1.359
– ident: 2019111714431152200_REF56
  doi: 10.1084/jem.179.1.185
– ident: 2019111714431152200_REF36
  doi: 10.1126/science.1060042
– ident: 2019111714431152200_REF4
  doi: 10.1038/nri1526
– ident: 2019111714431152200_REF38
  doi: 10.1128/IAI.70.5.2375-2382.2002
– ident: 2019111714431152200_REF22
  doi: 10.4049/jimmunol.165.9.4787
– ident: 2019111714431152200_REF10
  doi: 10.1016/j.immuni.2004.06.007
– ident: 2019111714431152200_REF33
  doi: 10.1182/blood-2003-03-0748
– ident: 2019111714431152200_REF64
  doi: 10.1128/JVI.61.10.3102-3108.1987
– ident: 2019111714431152200_REF28
  doi: 10.1038/ni1248
– ident: 2019111714431152200_REF20
  doi: 10.1038/ni1244
– ident: 2019111714431152200_REF55
  doi: 10.1128/JVI.67.9.5360-5366.1993
– ident: 2019111714431152200_REF19
  doi: 10.1038/ni736
– ident: 2019111714431152200_REF66
  doi: 10.1084/jem.188.3.577
– ident: 2019111714431152200_REF51
  doi: 10.1016/j.immuni.2005.03.008
– ident: 2019111714431152200_REF58
  doi: 10.1038/35093109
– ident: 2019111714431152200_REF37
  doi: 10.1046/j.1365-2249.2000.01110.x
– ident: 2019111714431152200_REF1
  doi: 10.1016/S1473-3099(04)01202-2
– ident: 2019111714431152200_REF13
  doi: 10.1128/JVI.78.3.1202-1211.2004
– ident: 2019111714431152200_REF30
  doi: 10.1016/j.tcb.2003.10.009
– ident: 2019111714431152200_REF57
  doi: 10.4049/jimmunol.175.12.8303
– ident: 2019111714431152200_REF9
  doi: 10.4049/jimmunol.175.10.6723
– ident: 2019111714431152200_REF35
  doi: 10.1128/JVI.71.4.2980-2987.1997
– ident: 2019111714431152200_REF62
  doi: 10.1084/jem.169.6.2191
SSID ssj0014325
Score 2.28157
Snippet Reactivation of latent human cytomegalovirus (HCMV) following allogeneic transplantation is a major cause of morbidity and mortality and predisposes to severe...
Abstract Reactivation of latent human cytomegalovirus (HCMV) following allogeneic transplantation is a major cause of morbidity and mortality and predisposes...
SourceID proquest
crossref
pubmed
pascalfrancis
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 3387
SubjectTerms Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
C-Reactive Protein - immunology
C-Reactive Protein - physiology
Cytomegalovirus - metabolism
Cytomegalovirus - pathogenicity
Dendritic Cells
Herpesviridae Infections
Human viral diseases
Infectious diseases
Interferon Regulatory Factor-3 - metabolism
Interferon-gamma
Interleukin-12
Medical sciences
Mice
Mice, Knockout
Muromegalovirus - metabolism
Muromegalovirus - pathogenicity
Myeloid Differentiation Factor 88
Nerve Tissue Proteins - immunology
Nerve Tissue Proteins - physiology
Pharmacology. Drug treatments
Serum Amyloid P-Component - immunology
Serum Amyloid P-Component - physiology
Signal Transduction
Toll-Like Receptor 9 - metabolism
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virus Activation
Title Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation
URI https://dx.doi.org/10.1182/blood-2006-03-009266
https://www.ncbi.nlm.nih.gov/pubmed/16840729
https://search.proquest.com/docview/68113506
Volume 108
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9NAEB6VVBxShSAtJRTCPCDerNh7-HhMo0aFNgiqturbar2xUSRwQp0K-u-ZPUxUqQiJN8vW2Kud8Rw7xwfwLhMly42IozrNy0gYpqOCl0lUlUWaaEk239XmzD6lxxfi45W82oJJ1wtjyyqD7vc63WnrcGcUdnO0Wixsjy-Z0yJLmD3ZZJL08DazaaYebI8PL09O_yQTBGceyICCZ0sQOujIsx756nAfVvPIDiBy4xLvtVA7K93SvtUe8OLvHqmzTNNn8DS4lDj2q34OW1XTh91xQ-H091t8j67I052e9-HhYXf1eNJBvfXh0Sxk2Hfhx2d33Ptr0SDHMMShRduEgrPJ7BK74q0GdTNH8jhNh4-GAfIHz0_PsLV18c1XtIDHP_Vti998sT6ul_jhbMpxQ7cHF9Oj88lxFGAZIkM_7DrSXPKiJnc3oYiWtp6XstRmnhhd1CQRWnIyvIyLOsvneZLGJi9qctJMXRtpcbL4C-g1y6Z6CZiVhguhWV7xzCVoSZ-YuJzLrGaiSvMBRB0r1MpP31AuasmZcqyzKJqpirnyrBtA1vFL3ZEiRQbiH5TDO-zdfI5CUooZxQDedvxWxB2bVtFNtbxpVUrPuYzpFfteDDa0dpIORS-v_ntZB_DECaetO5Svobe-vqnekBe0LodByofw4ORL_ht61ANd
link.rule.ids 315,786,790,27600,27955,27956,45696
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBalZWthjC3dJe3WnoexNxHbknx5TENDusZllLT0TciKXQKbks4pW__9ji5eKHQM9mZsji10js9F5_IR8injVZJrHtEmzSvKdaJowaqY1lWRxkqgzXe1OeVFOrniX27EzRYZdb0wtqwy6H6v0522DncGYTcHq8XC9viiOS2yOLEnm4lAPbyD3kCBYr4zPLk-n_5JJnCWeCADDJ4tQeigQ8964KvDfVjNqB1A5MYlPmmhXqxUi_vWeMCLv3ukzjKNX5GXwaWEoV_1a7JVmx7ZHxoMp78_wGdwRZ7u9LxHnp10V7ujDuqtR56XIcO-T-6-uuPeXwsDDMIQhxZsEwqUo_IauuItA8rMAT1O3eGjQYD8gdn0ElpbF29uwQIe_1QPLXzzxfqwXsLZ5ZjBhu4NuRqfzkYTGmAZqMYfdk0VE6xo0N2NMaLFrWeVqJSex1oVDUqEEgwNb8J4k-XzPE4jnRcNOmm6abSwOFnsLdk2S1O_J5BVmnGukrxmmUvQoj7RUTUXWZPwOs37hHaskCs_fUO6qCVPpGOdRdFMZcSkZ12fZB2_5CMpkmgg_kF59Ii9m89hSIoxI--T447fErlj0yrK1Mv7Vqb4nIkIX_HOi8GG1k7Swejl4L-XdUx2J7NyKqdnF-eHZM8Lqq22_EC21z_u64_oEa2royDxvwHTAgVf
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pentraxin+3+protects+from+MCMV+infection+and+reactivation+through+TLR+sensing+pathways+leading+to+IRF3+activation&rft.jtitle=Blood&rft.au=Bozza%2C+Silvia&rft.au=Bistoni%2C+Francesco&rft.au=Gaziano%2C+Roberta&rft.au=Pitzurra%2C+Lucia&rft.date=2006-11-15&rft.issn=0006-4971&rft.volume=108&rft.issue=10&rft.spage=3387&rft.epage=3396&rft_id=info:doi/10.1182%2Fblood-2006-03-009266&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-4971&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-4971&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-4971&client=summon