Origins and History of the Minimal Model of Glucose Regulation

• Published in: Frontiers in endocrinology (Lausanne) Vol. 11; p. 583016
• Main Author: Bergman, Richard N.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.02.2021
• Subjects: diabetes; disposition index; Endocrinology; glucose effectiveness; insulin clearance; mathematical model; metabolism; disposition index; mathematical model; metabolism; glucose effectiveness; insulin clearance; diabetes

It has long been hoped that our understanding of the pathogenesis of diabetes would be helped by the use of mathematical modeling. In 1979 Richard Bergman and Claudio Cobelli worked together to find a “minimal model” based upon experimental data from Bergman’s laboratory. Model was chosen as the sim...