Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for Treatment of Lung Adenocarcinoma

• Published in: Frontiers in pharmacology Vol. 12; p. 643489
• Main Authors: Guo, Shuai, Bai, Xue, Liu, Yufei, Shi, Sai, Wang, Xuzhao, Zhan, Yong, Kang, Xianjiang, Chen, Yafei, An, Hailong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.04.2021
• Subjects: inhibitor; lung adenocarcinoma; molecular target; Pharmacology; silibinin; TMEM16A; TMEM16A; inhibitor; silibinin; molecular target; lung adenocarcinoma

Background : Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed obvious antitumor efficacy. Methods : YFP fluoresc...