Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis

• Published in: Molecular and cellular biology Vol. 34; no. 10; pp. 1850 - 1862
• Main Authors: Riddle, Ryan C., Frey, Julie L., Tomlinson, Ryan E., Ferron, Mathieu, Li, Yuanyuan, DiGirolamo, Douglas J., Faugere, Marie-Claude, Hussain, Mehboob A., Karsenty, Gerard, Clemens, Thomas L.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.05.2014; American Society for Microbiology
• Subjects: Animals; Bone and Bones - cytology; Bone and Bones - diagnostic imaging; Bone and Bones - metabolism; Cell Differentiation; Cells, Cultured; Glucose - metabolism; Homeostasis; Insulin - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoblasts - physiology; Osteocalcin - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tumor Suppressor Proteins - physiology; X-Ray Microtomography

Insulin signaling in osteoblasts regulates global energy balance by stimulating the production of osteocalcin, a bone-derived protein that promotes insulin production and action. To identify the signaling pathways in osteoblasts that mediate insulin's effects on bone and energy metabolism, we e...