Reverse genetic approaches allowing the characterization of the rabies virus street strain belonging to the SEA4 subclade

• Published in: Scientific Reports Vol. 14; no. 1; pp. 18509 - 9
• Main Authors: Kawaguchi, Nijiho, Itakura, Yukari, Intaruck, Kittiya, Ariizumi, Takuma, Harada, Michiko, Inoue, Satoshi, Maeda, Ken, Ito, Naoto, Hall, William W., Sawa, Hirofumi, Orba, Yasuko, Sasaki, Michihito
• Format: Journal Article
• Language: English
• Published: London Springer Science and Business Media LLC 09.08.2024; Nature Publishing Group UK; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/596; 631/326/596/2555; 631/326/596/2557; Animals; Cell Line; Cell lines; Dogs; Genetics; Humanities and Social Sciences; Humans; Invasiveness; Live-cell imaging; Lyssavirus; Medicine; Mice; Molecular modelling; multidisciplinary; Neurological diseases; P protein; Pathogenicity; Pathogens; Philippines; Proteins; Q; R; Rabies; Rabies - virology; Rabies virus; Rabies virus - genetics; Rabies virus - pathogenicity; Reverse genetics; Reverse Genetics - methods; Science; Science (multidisciplinary); Strains (organisms); Street strain; Tropism; Viral pathogenicity; Virus Replication - genetics; Viruses; Philippines; Street strain; Live-cell imaging; Rabies virus; Viral pathogenicity; Reverse genetics

Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyoh...