Reverse genetic approaches allowing the characterization of the rabies virus street strain belonging to the SEA4 subclade

Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyoh...

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Published inScientific Reports Vol. 14; no. 1; pp. 18509 - 9
Main Authors Kawaguchi, Nijiho, Itakura, Yukari, Intaruck, Kittiya, Ariizumi, Takuma, Harada, Michiko, Inoue, Satoshi, Maeda, Ken, Ito, Naoto, Hall, William W., Sawa, Hirofumi, Orba, Yasuko, Sasaki, Michihito
Format Journal Article
LanguageEnglish
Published London Springer Science and Business Media LLC 09.08.2024
Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Subjects
631/326/596
631/326/596/2555
631/326/596/2557
Animals
Cell Line
Cell lines
Dogs
Genetics
Humanities and Social Sciences
Humans
Invasiveness
Live-cell imaging
Lyssavirus
Medicine
Mice
Molecular modelling
multidisciplinary
Neurological diseases
P protein
Pathogenicity
Pathogens
Philippines
Proteins
Q
R
Rabies
Rabies - virology
Rabies virus
Rabies virus - genetics
Rabies virus - pathogenicity
Reverse genetics
Reverse Genetics - methods
Science
Science (multidisciplinary)
Strains (organisms)
Street strain
Tropism
Viral pathogenicity
Virus Replication - genetics
Viruses
Philippines
Street strain
Live-cell imaging
Rabies virus
Viral pathogenicity
Reverse genetics
Online AccessGet full text

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Abstract Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyohashi strain is a street strain isolated in Japan from an imported case which had been bitten by rabid dog in the Philippines. In order to facilitate molecular studies of RABV, we established a reverse genetics (RG) system for the study of the Toyohashi strain. The recombinant virus was obtained from a cDNA clone of Toyohashi strain and exhibited similar growth efficiency as the original virus in cultured cell lines. Both the original and recombinant strains showed similar pathogenicity with high neuroinvasiveness in mice, and the infected mice developed a long and inconsistent incubation period, which is characteristic of street strains. We also generated a recombinant Toyohashi strain expressing viral phosphoprotein (P protein) fused with the fluorescent protein mCherry, and tracked the intracellular dynamics of the viral P protein using live-cell imaging. The presented reverse genetics system for Toyohashi strain will be a useful tool to explore the fundamental molecular mechanisms of the replication of RABV street strains.
AbstractList Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyohashi strain is a street strain isolated in Japan from an imported case which had been bitten by rabid dog in the Philippines. In order to facilitate molecular studies of RABV, we established a reverse genetics (RG) system for the study of the Toyohashi strain. The recombinant virus was obtained from a cDNA clone of Toyohashi strain and exhibited similar growth efficiency as the original virus in cultured cell lines. Both the original and recombinant strains showed similar pathogenicity with high neuroinvasiveness in mice, and the infected mice developed a long and inconsistent incubation period, which is characteristic of street strains. We also generated a recombinant Toyohashi strain expressing viral phosphoprotein (P protein) fused with the fluorescent protein mCherry, and tracked the intracellular dynamics of the viral P protein using live-cell imaging. The presented reverse genetics system for Toyohashi strain will be a useful tool to explore the fundamental molecular mechanisms of the replication of RABV street strains.
Abstract Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyohashi strain is a street strain isolated in Japan from an imported case which had been bitten by rabid dog in the Philippines. In order to facilitate molecular studies of RABV, we established a reverse genetics (RG) system for the study of the Toyohashi strain. The recombinant virus was obtained from a cDNA clone of Toyohashi strain and exhibited similar growth efficiency as the original virus in cultured cell lines. Both the original and recombinant strains showed similar pathogenicity with high neuroinvasiveness in mice, and the infected mice developed a long and inconsistent incubation period, which is characteristic of street strains. We also generated a recombinant Toyohashi strain expressing viral phosphoprotein (P protein) fused with the fluorescent protein mCherry, and tracked the intracellular dynamics of the viral P protein using live-cell imaging. The presented reverse genetics system for Toyohashi strain will be a useful tool to explore the fundamental molecular mechanisms of the replication of RABV street strains.
Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyohashi strain is a street strain isolated in Japan from an imported case which had been bitten by rabid dog in the Philippines. In order to facilitate molecular studies of RABV, we established a reverse genetics (RG) system for the study of the Toyohashi strain. The recombinant virus was obtained from a cDNA clone of Toyohashi strain and exhibited similar growth efficiency as the original virus in cultured cell lines. Both the original and recombinant strains showed similar pathogenicity with high neuroinvasiveness in mice, and the infected mice developed a long and inconsistent incubation period, which is characteristic of street strains. We also generated a recombinant Toyohashi strain expressing viral phosphoprotein (P protein) fused with the fluorescent protein mCherry, and tracked the intracellular dynamics of the viral P protein using live-cell imaging. The presented reverse genetics system for Toyohashi strain will be a useful tool to explore the fundamental molecular mechanisms of the replication of RABV street strains.Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyohashi strain is a street strain isolated in Japan from an imported case which had been bitten by rabid dog in the Philippines. In order to facilitate molecular studies of RABV, we established a reverse genetics (RG) system for the study of the Toyohashi strain. The recombinant virus was obtained from a cDNA clone of Toyohashi strain and exhibited similar growth efficiency as the original virus in cultured cell lines. Both the original and recombinant strains showed similar pathogenicity with high neuroinvasiveness in mice, and the infected mice developed a long and inconsistent incubation period, which is characteristic of street strains. We also generated a recombinant Toyohashi strain expressing viral phosphoprotein (P protein) fused with the fluorescent protein mCherry, and tracked the intracellular dynamics of the viral P protein using live-cell imaging. The presented reverse genetics system for Toyohashi strain will be a useful tool to explore the fundamental molecular mechanisms of the replication of RABV street strains.
ArticleNumber 18509
Author Michiko Harada
Takuma Ariizumi
Ken Maeda
Nijiho Kawaguchi
Naoto Ito
Satoshi Inoue
William W. Hall
Yukari Itakura
Kittiya Intaruck
Michihito Sasaki
Hirofumi Sawa
Yasuko Orba
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Keywords Street strain
Live-cell imaging
Rabies virus
Viral pathogenicity
Reverse genetics
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Snippet Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory...
Abstract Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains...
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SubjectTerms 631/326/596
631/326/596/2555
631/326/596/2557
Animals
Cell Line
Cell lines
Dogs
Genetics
Humanities and Social Sciences
Humans
Invasiveness
Live-cell imaging
Lyssavirus
Medicine
Mice
Molecular modelling
multidisciplinary
Neurological diseases
P protein
Pathogenicity
Pathogens
Philippines
Proteins
Q
R
Rabies
Rabies - virology
Rabies virus
Rabies virus - genetics
Rabies virus - pathogenicity
Reverse genetics
Reverse Genetics - methods
Science
Science (multidisciplinary)
Strains (organisms)
Street strain
Tropism
Viral pathogenicity
Virus Replication - genetics
Viruses
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Title Reverse genetic approaches allowing the characterization of the rabies virus street strain belonging to the SEA4 subclade
URI https://cir.nii.ac.jp/crid/1870584741566907520
https://link.springer.com/article/10.1038/s41598-024-69613-y
https://www.ncbi.nlm.nih.gov/pubmed/39122768
https://www.proquest.com/docview/3091023209
https://www.proquest.com/docview/3091282489
https://doaj.org/article/e25253fd096c4d6f9921a52a36893677
Volume 14
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