Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

• Published in: Immunity (Cambridge, Mass.) Vol. 25; no. 3; pp. 417 - 428
• Main Authors: Christensen, Sean R., Shupe, Jonathan, Nickerson, Kevin, Kashgarian, Michael, Flavell, Richard A., Shlomchik, Mark J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2006; Elsevier Limited
• Subjects: Animals; Antibody Specificity; Autoantibodies - biosynthesis; Autoimmune diseases; CELLIMMUNO; Cells, Cultured; Deoxyribonucleic acid; Dilution; DNA; Female; Humans; HUMDISEASE; Immune system; Immunoglobulin G - blood; Lupus; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - metabolism; Lupus Erythematosus, Systemic - pathology; Lymphocyte Activation - immunology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; MOLIMMUNO; Mortality; Rodents; Studies; Toll-Like Receptor 7 - deficiency; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - physiology; Toll-Like Receptor 9 - deficiency; Toll-Like Receptor 9 - genetics; Toll-Like Receptor 9 - physiology; MOLIMMUNO; HUMDISEASE; CELLIMMUNO

Antibodies (Abs) to RNA- and DNA-containing autoantigens are characteristic of systemic lupus erythematosus (SLE). We showed previously that Toll-like receptor (TLR) 9, recognizing DNA, is required for the spontaneous generation of DNA autoantibodies, but not for the development of lupus nephritis i...