Leptin and Obesity: Role and Clinical Implication

• Published in: Frontiers in endocrinology (Lausanne) Vol. 12; p. 585887
• Main Authors: Obradovic, Milan, Sudar-Milovanovic, Emina, Soskic, Sanja, Essack, Magbubah, Arya, Swati, Stewart, Alan J., Gojobori, Takashi, Isenovic, Esma R.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.05.2021
• Subjects: Animals; Endocrinology; Energy Metabolism - physiology; Humans; Hypothalamus - metabolism; Hypothalamus - physiopathology; leptin; Leptin - blood; Leptin - physiology; leptin receptor; leptin resistance; leptin-based therapies; obesity; Obesity - epidemiology; Obesity - etiology; Obesity - metabolism; Risk Factors; Satiety Response - physiology; Signal Transduction; leptin resistance; leptin; leptin receptor; obesity; leptin-based therapies

The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese ( ob ) gene and, following synthesis and secretion from fat cells in white adipose t...