Hypoxia and TGF-β1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation

• Published in: Cancer cell international Vol. 17; no. 1; pp. 54 - 16
• Main Authors: Xu, Feifei, Zhang, Jialu, Hu, Guolin, Liu, Lei, Liang, Weijiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 12.05.2017; BMC
• Subjects: Cervical cancer cells; EMT; Focal adhesion; Invasion; Migration; PLOD2; Primary Research; Cervical cancer cells; PLOD2; EMT; Migration; Invasion; Focal adhesion

Intra-tumoral hypoxia and increases in extracellular level of transforming growth factor β1 (TGF-β1), which are common findings in cancer, are associated with an increased risk of metastasis and mortality. Moreover, metastasis is the leading cause of death of patients with cervical cancer. PLOD2 is...