Cysteine cathepsins and extracellular matrix degradation

• Published in: Biochimica et biophysica acta Vol. 1840; no. 8; pp. 2560 - 2570
• Main Authors: Fonović, Marko, Turk, Boris
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2014
• Subjects: acidification; Animals; bone resorption; cardiovascular diseases; Cathepsin; cathepsin K; Cathepsins - chemistry; Cathepsins - metabolism; Collagen; cysteine; Cysteine - metabolism; drugs; elastin; Extracellular matrix; Extracellular Matrix - metabolism; Glycosaminoglycan; Humans; Lysosome; lysosomes; Molecular Targeted Therapy; neoplasms; Osteoporosis; protein metabolism; secretion; Substrate Specificity; Osteoporosis; Extracellular matrix; Glycosaminoglycan; Cathepsin; Collagen; Lysosome

Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of the extracellular matrix in vitro was first reported more than 25years ago. However, cathepsins were for a long time not considered to be amon...