Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes

• Published in: Frontiers in endocrinology (Lausanne) Vol. 12; p. 635175
• Main Authors: Roszczyc-Owsiejczuk, Kamila, Zabielski, Piotr
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.03.2021
• Subjects: Adenosine Triphosphate - metabolism; Animals; ceramide; Ceramides - metabolism; Diabetes Mellitus, Type 2 - metabolism; Diet, High-Fat; Endocrinology; Endoplasmic Reticulum - metabolism; Golgi Apparatus - metabolism; Humans; Insulin - metabolism; Insulin Resistance; Liver - metabolism; metabolism; Mitochondria - metabolism; mitochondrial dysfunction; Muscle, Skeletal - metabolism; Obesity - complications; Oxidative Stress; Oxidoreductases - metabolism; Signal Transduction; sphingolipids; Sphingolipids - metabolism; type 2 diabetes; ceramide; metabolism; mitochondrial dysfunction; type 2 diabetes; sphingolipids; insulin resistance

Insulin resistance is defined as a complex pathological condition of abnormal cellular and metabolic response to insulin. Obesity and consumption of high-fat diet lead to ectopic accumulation of bioactive lipids in insulin-sensitive tissues. Intracellular lipid accumulation is regarded as one of the...