HLA-B13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients

• Published in: Frontiers in immunology Vol. 12; p. 661135
• Main Authors: Satapornpong, Patompong, Pratoomwun, Jirawat, Rerknimitr, Pawinee, Klaewsongkram, Jettanong, Nakkam, Nontaya, Rungrotmongkol, Thanyada, Konyoung, Parinya, Saksit, Niwat, Mahakkanukrauh, Ajanee, Amornpinyo, Warayuwadee, Khunarkornsiri, Usanee, Tempark, Therdpong, Wantavornprasert, Kittipong, Jinda, Pimonpan, Koomdee, Napatrupron, Jantararoungtong, Thawinee, Rerkpattanapipat, Ticha, Wang, Chuang-Wei, Naisbitt, Dean, Tassaneeyakul, Wichittra, Ariyachaipanich, Manasalak, Roonghiranwat, Thapana, Pirmohamed, Munir, Chung, Wen-Hung, Sukasem, Chonlaphat
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.05.2021
• Subjects: Adolescent; Adult; Aged; Alleles; Asian People - statistics & numerical data; Child; Child, Preschool; Cytochrome P-450 Enzyme System - genetics; cytochrome P450; Dapsone - adverse effects; dapsone-induced severe cutaneous adverse reactions; Female; Genetic Association Studies; Genetic Markers; Genotype; HLA class I and II alleles; HLA-B Antigens - classification; HLA-B Antigens - genetics; HLA-B13:01; Humans; Immunology; Male; Middle Aged; Molecular Docking Simulation; Polymorphism, Genetic; Prospective Studies; Skin - drug effects; Skin - pathology; Thais and Taiwaneses; Young Adult; HLA-B13:01; HLA class I and II alleles; Thais and Taiwaneses; cytochrome P450; dapsone-induced severe cutaneous adverse reactions

HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. Dapsone hydroxylamine (DDS-NHOH), an active metabolite of dapsone, has been believed to be responsible for DHS. However, studies hav...