Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis - Argyropoulos, Panos; Bergeret, Fabien; Pardin, Christophe; Reimer, Janice M.; Pinto, Atahualpa; Boddy, Christopher N.; Schmeing, T. Martin (Biochimica et biophysica acta, 2016)
Keywords: biosynthesis; biphenyl; Catalytic Domain; erythromycin; Erythromycin - analogs & derivatives; Erythromycin - biosynthesis; High-resolution structure; hydrolysis; Inhibition; Non-hydrolyzable acyl-enzyme intermediates; Polyketide synthase; polyketide synthases; Protein Structure, Tertiary; Substrate Specificity; therapeutics; Thioesterase; Thiolester Hydrolases - chemistry; transesterification; Polyketide synthase; High-resolution structure; Thioesterase; Inhibition; Non-hydrolyzable acyl-enzyme intermediates