The Lsm1-7-Pat1 complex promotes viral RNA translation and replication by differential mechanisms

• Published in: RNA (Cambridge) Vol. 21; no. 8; pp. 1469 - 1479
• Main Authors: Jungfleisch, Jennifer, Chowdhury, Ashis, Alves-Rodrigues, Isabel, Tharun, Sundaresan, Díez, Juana
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.08.2015
• Subjects: BMV; Brome mosaic virus; Bromovirus - genetics; Bromovirus - physiology; Decapping activators; Lsm proteins; Lsm1-7; Lsm1-7-Pat1 complex; Metabolisme; Mutation; Pat1; Regulatory Sequences, Ribonucleic Acid; Replication; RNA Cap-Binding Proteins - genetics; RNA Cap-Binding Proteins - metabolism; RNA missatger; RNA virus; RNA, Messenger - metabolism; RNA, Viral - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae - virology; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Translation; Viral Proteins - metabolism; Viral RNA; Virology - methods; Virus Replication; replication; Lsm1-7; Lsm1-7-Pat1 complex; RNA virus; Lsm proteins; translation; BMV; Pat1; viral RNA; decapping activators

The Lsm1-7-Pat1 complex binds to the 3′ end of cellular mRNAs and promotes 3′ end protection and 5′–3′ decay. Interestingly, this complex also specifically binds to cis -acting regulatory sequences of viral positive-strand RNA genomes promoting their translation and subsequent recruitment from trans...