Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 25; no. 6; pp. 881 - 891
• Main Authors: Young, Elizabeth A, Altemus, Margaret, Parkison, Valerie, Shastry, Savitha
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2001; Nature Publishing; Nature Publishing Group
• Subjects: Adrenocorticotropic Hormone - metabolism; Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Behavioral psychophysiology; Biological and medical sciences; Corticosterone - administration & dosage; Corticosterone - pharmacology; Drug Implants - administration & dosage; Drug Implants - pharmacology; Estradiol - pharmacology; Estrogen; Estrogen Antagonists - pharmacology; Estrogens; Estrogens - agonists; Feedback - drug effects; Female; Females; Fundamental and applied biological sciences. Psychology; Gender differences; Glucocarticoids; Glucocorticoids - antagonists & inhibitors; Hormones; Hormones and behavior; HPA axis; Hypothalamo-Hypophyseal System - drug effects; Male; Males; Nitromifene - pharmacology; Oophorectomy; Ovariectomy; Progesterone - pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Restraint, Physical; stress; Stress, Psychological - metabolism; Tamoxifen; Tamoxifen - pharmacology; Ann Arbor Michigan; United States > US; stress; HPA axis; Glucocarticoids; Tamoxifen; Estrogen; Estrogen receptor; Agonist; Intraperitoneal administration; Rat; Hypothalamohypophysoadrenal axis; Corticosterone; Peptide hormone; Antiestrogen; Antihormone; Glucocorticoid; Estradiol; Progestagen; Female; Antagonist; Non steroid compound; Steroid hormone; Rodentia; Emotion emotionality; Long term; Ovarian hormone; Stress; Tamoxifene; Vertebrata; Mammalia; Adrenocorticotropic hormone; Adenohypophyseal hormone; Animal; Adrenal hormone; Progesterone; Sex steroid hormone

Previous studies have found that female rats are less sensitive than males to hypothalamic-pituitary-adrenal axis feedback inhibition by exogenous glucocorticoid administration. To determine whether estrogen contributes to this sex difference, we examined the effects of the estrogen antagonists tamo...