Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease

• Published in: Frontiers in cell and developmental biology Vol. 9; p. 632843
• Main Authors: Huang, Xianfeng, Yang, Jinyao, Huang, Xi, Zhang, Zaijun, Liu, Jianjun, Zou, Liangyu, Yang, Xifei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.03.2021
• Subjects: Alzheimer's disease; Cell and Developmental Biology; mitochondria; OxPhoS; proteomics; tetramethylpyrazine; tetramethylpyrazine; OxPhoS; proteomics; Alzheimer's disease; mitochondria

Alzheimer's disease (AD), one of the most common neurodegenerative diseases, has no effective treatment. We studied the potential effects of tetramethylpyrazine (TMP), an alkaloid in the rhizome of Ligusticum chuanxiong Hort. used in Traditional Chinese Medicine ( chuānxiong ) to treat ischemic...