Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to...

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Published inFrontiers in cell and developmental biology Vol. 10; p. 786031
Main Authors Hishida, Tomoaki, Vazquez-Ferrer, Eric, Hishida-Nozaki, Yuriko, Takemoto, Yuto, Hatanaka, Fumiyuki, Yoshida, Kei, Prieto, Javier, Sahu, Sanjeeb Kumar, Takahashi, Yuta, Reddy, Pradeep, O’Keefe, David D., Rodriguez Esteban, Concepcion, Knoepfler, Paul S., Nuñez Delicado, Estrella, Castells, Antoni, Campistol, Josep M., Kato, Ryuji, Nakagawa, Hiroshi, Izpisua Belmonte, Juan Carlos
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.03.2022
Subjects
aging
cancer
Cell and Developmental Biology
mitochondria highlights
MYC
senescence
senescence
cancer
aging
MYC
mitochondria highlights
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Summary:It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout-induced senescence, therefore suggesting that a mitochondrial superoxide takes part in inducing senescence. Taken together, these analyses reveal extremely low levels of cellular senescence and senescence-associated phenotypes in the esophageal epithelium, as well as a critical role for Myc in self-renewal of basal cells in this organ. This provides new avenues for studying and understanding the links between stemness and resistance to cellular senescence.
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Reviewed by: Viacheslav Senichkin, Lomonosov Moscow State University, Russia
Demitrios Vynios, University of Patras, Greece
Edited by: Gelina Kopeina, Lomonosov Moscow State University, Russia
Takafumi Suzuki, Tohoku University, Japan
Present Address: Sanjeeb Kumar Sahu, Altos Labs, San Diego, CA
Juan Carlos Izpisua Belmonte, Altos Labs, San Diego, CA
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.786031