Structure and mechanism of ATP-dependent phospholipid transporters

• Published in: Biochimica et biophysica acta Vol. 1850; no. 3; pp. 461 - 475
• Main Authors: López-Marqués, Rosa L., Poulsen, Lisbeth Rosager, Bailly, Aurélien, Geisler, Markus, Pomorski, Thomas Günther, Palmgren, Michael G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2015
• Subjects: ABC transporter; ABC transporters; adenosine triphosphate; Adenosine Triphosphate - metabolism; adenosinetriphosphatase; Animals; Biological Transport; biophysics; Cell Membrane - metabolism; crystal structure; Flippase; Humans; hydrophobicity; Lipid flipping; Membrane Transport Proteins - chemistry; Membrane Transport Proteins - metabolism; Models, Molecular; P-type ATPase; P4-ATPase; Phospholipid Transfer Proteins - chemistry; Phospholipid Transfer Proteins - metabolism; phospholipids; Phospholipids - metabolism; Protein Conformation; pumps; Transport; Lipid flipping; Transport; P-type ATPase; ABC transporter; Flippase; P4-ATPase

ATP-binding cassette (ABC) transporters and P4-ATPases are two large and seemingly unrelated families of primary active pumps involved in moving phospholipids from one leaflet of a biological membrane to the other. This review aims to identify common mechanistic features in the way phospholipid flip...